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Lasers Med Sci:激光能否有效治疗黄褐斑?

2022-07-29 sunshine MedSci原创

黄褐斑是一种高发的、有损外观的色素性皮肤病。治疗后的效果往往不尽人意。大量的临床试验试图证明涉及激光治疗的综合疗法的有效性,但结果并不确定。

黄褐斑是一种高发的、有损外观的色素性皮肤病。治疗后的效果往往不尽人意。大量的临床试验试图证明涉及激光治疗的综合疗法的有效性,但结果并不确定。近日,发表于Lasers Med Sci的一项系统回顾和荟萃分析评估了激光治疗黄褐斑的有效性。

研究人员分别检索了4个数据库和clinicaltrials.gov截至2021年6月8日收录的相关文献。两位研究人员独立搜索文献并提取数据。通过加权平均差异(WMD)计算研究结果。所有的统计分析都是由Review Manager 5.3版、STATA 14版软件在95%的置信区间内进行的。

结果,研究人员共纳入了22项符合条件的研究,包括694名患者。经过异质性检验和敏感性分析,对不同类型的激光治疗前后的情况进行了亚组荟萃分析。结果发现,大多数激光和基于激光的组合与黄褐斑面积和严重程度指数(MASI)的降低有关,如低流量Q-switch 1,064纳米Nd:YAG激光(QSNYL)(WMD:-2. 76;95%CI:-3.53至-1.99),点阵消融式二氧化碳激光(WMD:-9.36;95%CI:-12.51至-6.21),以及点阵消融式2940-纳米Er:YAG激光(WMD:-2,72;95%CI:-3.94至-1.49)。非剥脱性1550纳米点阵激光(WMD: -1.29; 95% CI: -2.80 to 0.21)和皮秒激光(WMD: -0.58; 95% CI: -1.43 to 0.27)的MASI评分和低流量QSNYL治疗的黑色素指数(MI)均未见明显下降。使用激光治疗黄褐斑时,可能会出现各种不良反应,其中大部分会在不进行后续治疗的情况下迅速解决,如治疗后出现水肿、红斑、脱屑、烧灼感等。然而,对于皮肤较黑的患者来说,存在着炎症后色素沉着和色素减退的风险。

综上所述,该项系统回顾和荟萃分析显示,激光和基于激光的联合治疗黄褐斑可以显著降低MASI评分。

原始出处:

Dihui Lai, et al., Laser therapy in the treatment of melasma: a systematic review and meta-analysis. Lasers Med Sci. 2022 Jun;37(4):2099-2110. doi: 10.1007/s10103-022-03514-2.  

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    2022-12-16 anminleiryan
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    2022-07-24 oliver169
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