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Oral Oncol:HPV感染可促使年轻个体头颈癌的发生率升高

2015-06-21 MedSci MedSci原创

Oral Oncol:HPV感染可促使年轻个体头颈癌的发生率升高 在过去的30年里,头部和颈部肿瘤的面貌发生了巨大的变化。与烟草和酒精相关的鳞状细胞癌在过去的30年里稳步下降,但是与人乳头瘤病毒(HPV)相关的肿瘤发病率却逐渐增加,且较易发生在40-50岁的非吸烟人群中。有研究表明,约70-90%的新发口咽癌存在HPV感染。有研究表明,一生中口交伴侣(>5)以及阴道性交伴侣(>25)较高与HPV阳




在过去的30年里,头部和颈部肿瘤的面貌发生了巨大的变化。与烟草和酒精相关的鳞状细胞癌在过去的30年里稳步下降,但是与人乳头瘤病毒(HPV)相关的肿瘤发病率却逐渐增加,且较易发生在40-50岁的非吸烟人群中。有研究表明,约70-90%的新发口咽癌存在HPV感染。

有研究表明,一生中口交伴侣(>5)以及阴道性交伴侣(>25)较高与HPV阳性头颈癌患者的高风险有关。人们可以在性活跃年龄之前通过接受HPV疫苗免疫以降低HPV相关的头颈癌发生的风险。

最近的证据表明,相对于烟草相关性头颈癌,HPV相关的头颈癌可表现出多种不同的症状。HPV最流行的检测方法为p16免疫组化染色,廉价且简单,研究表明它较以往的标准检测方法灵敏性和特异性高。现在普遍建议所有口咽癌患者进行HPV检测,有些地方甚至建议所有头颈癌患者均应进行HPV检测。

HPV阳性的头颈癌患者的2年和5年总生存率明显高于HPV阴性的头颈癌患者,这可能是由于HPV阳性的肿瘤对治疗反应更为灵敏。

原始出处:

Young D, Xiao CC, Murphy B, Moore M, Fakhry C, Day TA.Increase in head and neck cancer in younger patients due to human papillomavirus (HPV).Oral Oncol.  2015 Jun 8. pii: S1368-8375(15)00182-7. doi: 10.1016/j.oraloncology.2015.03.015.


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  1. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Mon Dec 28 03:13:00 CST 2015, time=2015-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1295868, encodeId=c69d1295868eb, content=<a href='/topic/show?id=f30a4441598' target=_blank style='color:#2F92EE;'>#头颈癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44415, encryptionId=f30a4441598, topicName=头颈癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c32257, createdName=DEXTER3139, createdTime=Tue Jun 23 04:13:00 CST 2015, time=2015-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483030, encodeId=96341483030ea, content=<a href='/topic/show?id=0ac39080cc' target=_blank style='color:#2F92EE;'>#HPV感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9080, encryptionId=0ac39080cc, topicName=HPV感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56437868203, createdName=ms3415360956839622, createdTime=Tue Jun 23 04:13:00 CST 2015, time=2015-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28655, encodeId=655f286558f, content=中国相对减少, beContent=null, objectType=article, channel=null, level=null, likeNumber=170, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90ea1614944, createdName=huangwukui, createdTime=Mon Jun 22 18:53:00 CST 2015, time=2015-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28654, encodeId=c26d28654d3, content=这个主要是老外, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90ea1614944, createdName=huangwukui, createdTime=Mon Jun 22 18:52:00 CST 2015, time=2015-06-22, status=1, ipAttribution=)]
    2016-09-13 1e10c84am36(暂无匿称)

    好文章,还会关注

    0

  2. 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content=这个主要是老外, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90ea1614944, createdName=huangwukui, createdTime=Mon Jun 22 18:52:00 CST 2015, time=2015-06-22, status=1, ipAttribution=)]
    2016-07-19 De_dzw

    这个,还是值得深入研究的

    0

  3. 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content=这个主要是老外, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90ea1614944, createdName=huangwukui, createdTime=Mon Jun 22 18:52:00 CST 2015, time=2015-06-22, status=1, ipAttribution=)]
    2016-06-11 1def77d0m63(暂无匿称)

    在国内少有医院对口腔癌患者常规查HPV

    0

  4. 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CST 2016, time=2016-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=89452, encodeId=217c89452fb, content=在国内少有医院对口腔癌患者常规查HPV, beContent=null, objectType=article, channel=null, level=null, likeNumber=172, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160611/IMG575C2E42D65DD2223.jpg, createdBy=e1e61734952, createdName=1def77d0m63(暂无匿称), createdTime=Sat Jun 11 23:39:00 CST 2016, time=2016-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2020174, encodeId=4f3820201e4f3, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Tue Dec 08 16:13:00 CST 2015, time=2015-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1826279, encodeId=315818262e9db, content=<a href='/topic/show?id=e5283e89970' target=_blank style='color:#2F92EE;'>#发生率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37899, encryptionId=e5283e89970, topicName=发生率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Thu Aug 27 16:13:00 CST 2015, time=2015-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864670, encodeId=a92818646e0be, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Mon Dec 28 03:13:00 CST 2015, time=2015-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1295868, encodeId=c69d1295868eb, content=<a href='/topic/show?id=f30a4441598' target=_blank style='color:#2F92EE;'>#头颈癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44415, encryptionId=f30a4441598, topicName=头颈癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c32257, createdName=DEXTER3139, createdTime=Tue Jun 23 04:13:00 CST 2015, time=2015-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483030, encodeId=96341483030ea, content=<a href='/topic/show?id=0ac39080cc' target=_blank style='color:#2F92EE;'>#HPV感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9080, encryptionId=0ac39080cc, topicName=HPV感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56437868203, createdName=ms3415360956839622, createdTime=Tue Jun 23 04:13:00 CST 2015, time=2015-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28655, encodeId=655f286558f, content=中国相对减少, beContent=null, objectType=article, channel=null, level=null, likeNumber=170, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90ea1614944, createdName=huangwukui, createdTime=Mon Jun 22 18:53:00 CST 2015, time=2015-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28654, encodeId=c26d28654d3, content=这个主要是老外, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90ea1614944, createdName=huangwukui, createdTime=Mon Jun 22 18:52:00 CST 2015, time=2015-06-22, status=1, ipAttribution=)]
    2015-12-08 小几洁
  5. [GetPortalCommentsPageByObjectIdResponse(id=125047, encodeId=e9c312504e9a, content=好文章,还会关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 13 11:51:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93521, encodeId=2221935219e, content=这个,还是值得深入研究的, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151119/IMG564D22F85A3BB6344.jpg, createdBy=750e1664472, createdName=De_dzw, createdTime=Tue Jul 19 01:23:00 CST 2016, time=2016-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=89452, encodeId=217c89452fb, content=在国内少有医院对口腔癌患者常规查HPV, beContent=null, objectType=article, channel=null, level=null, likeNumber=172, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160611/IMG575C2E42D65DD2223.jpg, createdBy=e1e61734952, createdName=1def77d0m63(暂无匿称), createdTime=Sat Jun 11 23:39:00 CST 2016, time=2016-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2020174, encodeId=4f3820201e4f3, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Tue Dec 08 16:13:00 CST 2015, time=2015-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1826279, encodeId=315818262e9db, content=<a href='/topic/show?id=e5283e89970' target=_blank style='color:#2F92EE;'>#发生率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37899, encryptionId=e5283e89970, topicName=发生率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Thu Aug 27 16:13:00 CST 2015, time=2015-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864670, encodeId=a92818646e0be, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Mon Dec 28 03:13:00 CST 2015, time=2015-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1295868, encodeId=c69d1295868eb, content=<a href='/topic/show?id=f30a4441598' target=_blank style='color:#2F92EE;'>#头颈癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44415, encryptionId=f30a4441598, topicName=头颈癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c32257, createdName=DEXTER3139, createdTime=Tue Jun 23 04:13:00 CST 2015, time=2015-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483030, encodeId=96341483030ea, content=<a href='/topic/show?id=0ac39080cc' target=_blank style='color:#2F92EE;'>#HPV感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9080, encryptionId=0ac39080cc, topicName=HPV感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56437868203, createdName=ms3415360956839622, createdTime=Tue Jun 23 04:13:00 CST 2015, time=2015-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28655, encodeId=655f286558f, content=中国相对减少, beContent=null, objectType=article, channel=null, level=null, likeNumber=170, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90ea1614944, createdName=huangwukui, createdTime=Mon Jun 22 18:53:00 CST 2015, time=2015-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28654, encodeId=c26d28654d3, content=这个主要是老外, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90ea1614944, createdName=huangwukui, createdTime=Mon Jun 22 18:52:00 CST 2015, time=2015-06-22, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=125047, encodeId=e9c312504e9a, content=好文章,还会关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 13 11:51:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93521, encodeId=2221935219e, content=这个,还是值得深入研究的, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151119/IMG564D22F85A3BB6344.jpg, createdBy=750e1664472, createdName=De_dzw, createdTime=Tue Jul 19 01:23:00 CST 2016, time=2016-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=89452, encodeId=217c89452fb, content=在国内少有医院对口腔癌患者常规查HPV, beContent=null, objectType=article, channel=null, level=null, likeNumber=172, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160611/IMG575C2E42D65DD2223.jpg, createdBy=e1e61734952, createdName=1def77d0m63(暂无匿称), createdTime=Sat Jun 11 23:39:00 CST 2016, time=2016-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2020174, encodeId=4f3820201e4f3, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Tue Dec 08 16:13:00 CST 2015, time=2015-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1826279, encodeId=315818262e9db, content=<a href='/topic/show?id=e5283e89970' target=_blank style='color:#2F92EE;'>#发生率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37899, encryptionId=e5283e89970, topicName=发生率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Thu Aug 27 16:13:00 CST 2015, time=2015-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864670, encodeId=a92818646e0be, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Mon Dec 28 03:13:00 CST 2015, time=2015-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1295868, encodeId=c69d1295868eb, content=<a href='/topic/show?id=f30a4441598' target=_blank style='color:#2F92EE;'>#头颈癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44415, encryptionId=f30a4441598, topicName=头颈癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c32257, createdName=DEXTER3139, createdTime=Tue Jun 23 04:13:00 CST 2015, time=2015-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483030, encodeId=96341483030ea, content=<a href='/topic/show?id=0ac39080cc' target=_blank style='color:#2F92EE;'>#HPV感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9080, encryptionId=0ac39080cc, topicName=HPV感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56437868203, createdName=ms3415360956839622, createdTime=Tue Jun 23 04:13:00 CST 2015, time=2015-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28655, encodeId=655f286558f, content=中国相对减少, beContent=null, objectType=article, channel=null, level=null, likeNumber=170, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90ea1614944, createdName=huangwukui, createdTime=Mon Jun 22 18:53:00 CST 2015, time=2015-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28654, encodeId=c26d28654d3, content=这个主要是老外, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90ea1614944, createdName=huangwukui, createdTime=Mon Jun 22 18:52:00 CST 2015, time=2015-06-22, status=1, ipAttribution=)]
    2015-12-28 minlingfeng
  7. [GetPortalCommentsPageByObjectIdResponse(id=125047, encodeId=e9c312504e9a, content=好文章,还会关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 13 11:51:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93521, encodeId=2221935219e, content=这个,还是值得深入研究的, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151119/IMG564D22F85A3BB6344.jpg, createdBy=750e1664472, createdName=De_dzw, createdTime=Tue Jul 19 01:23:00 CST 2016, time=2016-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=89452, encodeId=217c89452fb, content=在国内少有医院对口腔癌患者常规查HPV, beContent=null, objectType=article, channel=null, level=null, likeNumber=172, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160611/IMG575C2E42D65DD2223.jpg, createdBy=e1e61734952, createdName=1def77d0m63(暂无匿称), createdTime=Sat Jun 11 23:39:00 CST 2016, time=2016-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2020174, encodeId=4f3820201e4f3, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Tue Dec 08 16:13:00 CST 2015, time=2015-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1826279, encodeId=315818262e9db, content=<a href='/topic/show?id=e5283e89970' target=_blank style='color:#2F92EE;'>#发生率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37899, encryptionId=e5283e89970, topicName=发生率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Thu Aug 27 16:13:00 CST 2015, time=2015-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864670, encodeId=a92818646e0be, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Mon Dec 28 03:13:00 CST 2015, time=2015-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1295868, encodeId=c69d1295868eb, content=<a href='/topic/show?id=f30a4441598' target=_blank style='color:#2F92EE;'>#头颈癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44415, encryptionId=f30a4441598, topicName=头颈癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c32257, createdName=DEXTER3139, createdTime=Tue Jun 23 04:13:00 CST 2015, time=2015-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483030, encodeId=96341483030ea, content=<a href='/topic/show?id=0ac39080cc' target=_blank style='color:#2F92EE;'>#HPV感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9080, encryptionId=0ac39080cc, topicName=HPV感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56437868203, createdName=ms3415360956839622, createdTime=Tue Jun 23 04:13:00 CST 2015, time=2015-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28655, encodeId=655f286558f, content=中国相对减少, beContent=null, objectType=article, channel=null, level=null, likeNumber=170, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90ea1614944, createdName=huangwukui, createdTime=Mon Jun 22 18:53:00 CST 2015, time=2015-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28654, encodeId=c26d28654d3, content=这个主要是老外, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90ea1614944, createdName=huangwukui, createdTime=Mon Jun 22 18:52:00 CST 2015, time=2015-06-22, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=125047, encodeId=e9c312504e9a, content=好文章,还会关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 13 11:51:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93521, encodeId=2221935219e, content=这个,还是值得深入研究的, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151119/IMG564D22F85A3BB6344.jpg, createdBy=750e1664472, createdName=De_dzw, createdTime=Tue Jul 19 01:23:00 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beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Mon Dec 28 03:13:00 CST 2015, time=2015-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1295868, encodeId=c69d1295868eb, content=<a href='/topic/show?id=f30a4441598' target=_blank style='color:#2F92EE;'>#头颈癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44415, encryptionId=f30a4441598, topicName=头颈癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c32257, createdName=DEXTER3139, createdTime=Tue Jun 23 04:13:00 CST 2015, time=2015-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483030, encodeId=96341483030ea, content=<a href='/topic/show?id=0ac39080cc' target=_blank style='color:#2F92EE;'>#HPV感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9080, encryptionId=0ac39080cc, topicName=HPV感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56437868203, createdName=ms3415360956839622, createdTime=Tue Jun 23 04:13:00 CST 2015, time=2015-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28655, encodeId=655f286558f, content=中国相对减少, beContent=null, objectType=article, channel=null, level=null, likeNumber=170, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90ea1614944, createdName=huangwukui, createdTime=Mon Jun 22 18:53:00 CST 2015, time=2015-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28654, encodeId=c26d28654d3, content=这个主要是老外, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90ea1614944, createdName=huangwukui, createdTime=Mon Jun 22 18:52:00 CST 2015, time=2015-06-22, status=1, ipAttribution=)]
  9. 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encodeId=96341483030ea, content=<a href='/topic/show?id=0ac39080cc' target=_blank style='color:#2F92EE;'>#HPV感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9080, encryptionId=0ac39080cc, topicName=HPV感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56437868203, createdName=ms3415360956839622, createdTime=Tue Jun 23 04:13:00 CST 2015, time=2015-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28655, encodeId=655f286558f, content=中国相对减少, beContent=null, objectType=article, channel=null, level=null, likeNumber=170, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90ea1614944, createdName=huangwukui, createdTime=Mon Jun 22 18:53:00 CST 2015, time=2015-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28654, encodeId=c26d28654d3, content=这个主要是老外, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90ea1614944, createdName=huangwukui, createdTime=Mon Jun 22 18:52:00 CST 2015, time=2015-06-22, status=1, ipAttribution=)]
    2015-06-22 huangwukui

    中国相对减少

    0

  10. 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encodeId=96341483030ea, content=<a href='/topic/show?id=0ac39080cc' target=_blank style='color:#2F92EE;'>#HPV感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9080, encryptionId=0ac39080cc, topicName=HPV感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56437868203, createdName=ms3415360956839622, createdTime=Tue Jun 23 04:13:00 CST 2015, time=2015-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28655, encodeId=655f286558f, content=中国相对减少, beContent=null, objectType=article, channel=null, level=null, likeNumber=170, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90ea1614944, createdName=huangwukui, createdTime=Mon Jun 22 18:53:00 CST 2015, time=2015-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28654, encodeId=c26d28654d3, content=这个主要是老外, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90ea1614944, createdName=huangwukui, createdTime=Mon Jun 22 18:52:00 CST 2015, time=2015-06-22, status=1, ipAttribution=)]
    2015-06-22 huangwukui

    这个主要是老外

    0

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