科学家拟用“大数据”解决流感！

2015-12-10 Seven L 译 MedSci原创

几乎每年都发生流感流行。有时新病毒株甚至可以导致全球大流行。近年来发现治疗流感药物对A型流感病毒(IAV)不敏感，产生了耐药性。流感是由流感病毒感染引起的，导致严重的呼吸道症状。病毒依靠宿主分子在呼吸道细胞内繁殖。近年来尝试识别和阻断该进程的宿主分子，以阻止病毒复制。苏黎世大学参与的一项国际研究探究这种方法。来自瑞士、德国和美国的研究团队分析了关于IAV宿主分子的文献。这些研究关注病毒所需的全部基

几乎每年都发生流感流行。有时新病毒株甚至可以导致全球大流行。近年来发现治疗流感药物对A型流感病毒(IAV)不敏感，产生了耐药性。流感是由流感病毒感染引起的，导致严重的呼吸道症状。病毒依靠宿主分子在呼吸道细胞内繁殖。近年来尝试识别和阻断该进程的宿主分子，以阻止病毒复制。

苏黎世大学参与的一项国际研究探究这种方法。来自瑞士、德国和美国的研究团队分析了关于IAV宿主分子的文献。这些研究关注病毒所需的全部基因('GenOMICs')和蛋白质('ProteOMICs')以及大数据。对'OMIC'数据库进行综合分析，识别了20种先前不清楚的促进IAV生长的宿主分子。

苏黎世大学病毒学研究所Silke Stertz教授说：“这些不变的宿主蛋白对病毒的复制至关重要。我们现在可以使用这些来阻止病毒进一步蔓延。“其中一个宿主蛋白质是UBR4，病毒需要它来运输病毒蛋白质到细胞膜及构建新粒子。IAV侵入宿主细胞，病毒关键成分跑到细胞膜上形成新病毒；因此从一个单一感染宿主细胞可以繁殖到多达20000个新流感病毒。

研究表明阻断UBR4可抑制感染细胞产生新病毒。例如在小鼠中，IAV复制可能被削弱，减缓疾病进展。因此该研究提供了证据，阻断宿主分子是可行的治疗流感的治疗策略！

该研究小组创建了一个关于流感和宿主相互作用的简化的、使用方便的门户网站。其他研究人员也可以访问这个网站，允许单个请求和提供了分析工具，以跟踪可能参与流感感染的宿主蛋白质。公布的数据可以帮助开发下一代的流感药物。

加利福尼亚SBP的Sumit Chanda，也是本研究的作者之一说：“我们期待本研究谈到的方法，使用“大数据”建立生物医学研究和治疗间的桥梁，对悬而未决的医疗问题提供新的视野！”

原始出处：

Using 'big data' to fight flu.MedicalNewsToday.Dec 9,2015

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2015-12-26 hixiaoluo

好文章，值得看。

138 0
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2015-12-26 hixiaoluo

好文章，值得看。

133 0
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2015-12-18 三三五五

不知道怎么执行方案。。。

152 0
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2015-12-12 zm0805

嗯

122 0
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2015-12-12 zm0805

明白啦

158 0
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2015-12-11 科研小旋风

长知识

98 0
[GetPortalCommentsPageByObjectIdResponse(id=48540, encodeId=b51e48540a6, content=好文章，值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 17:26:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48541, encodeId=fdef48541f1, content=好文章，值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 17:26:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=46656, encodeId=1d0446656d9, content=不知道怎么执行方案。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Fri Dec 18 22:53:00 CST 2015, time=2015-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=45709, encodeId=1d3d45e090e, content=嗯, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19691629579, createdName=zm0805, createdTime=Sat Dec 12 16:23:00 CST 2015, time=2015-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=45710, encodeId=721445e105c, content=明白啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19691629579, createdName=zm0805, createdTime=Sat Dec 12 16:23:00 CST 2015, time=2015-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=45633, encodeId=7c0945633fd, content=长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dd261670317, createdName=科研小旋风, createdTime=Fri Dec 11 23:33:00 CST 2015, time=2015-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=45602, encodeId=29e34560287, content=当年的谷歌，试图解决流感的流行问题，最终失败了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Fri Dec 11 20:21:00 CST 2015, time=2015-12-11, status=1, ipAttribution=)]
2015-12-11 medcardio

当年的谷歌，试图解决流感的流行问题，最终失败了。

103 0

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