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Nature:MERS爆发并非是全球威胁

2015-06-09 佚名 生物谷

全世界都在关注的除中东以外最大的爆发地——韩国的中东呼吸道综合征(MERS)疫情。根据最近来自世界卫生组织的数据,87人被感染,其中5人已经死亡,数百所学校已经关闭。MERS冠状病毒,是被视为潜在的有大流行威胁的诸多病毒之一。但专家并不认为这次爆发有可能引起大流行,甚至能在韩国境内进一步蔓延。部分原因如下: MERS不是人类病毒 引起大流行的病毒,首先它必须能够轻松地在人与人之间传播。但首次于

全世界都在关注的除中东以外最大的爆发地——韩国的中东呼吸道综合征(MERS)疫情。根据最近来自世界卫生组织的数据,87人被感染,其中5人已经死亡,数百所学校已经关闭。MERS冠状病毒,是被视为潜在的有大流行威胁的诸多病毒之一。但专家并不认为这次爆发有可能引起大流行,甚至能在韩国境内进一步蔓延。部分原因如下:

MERS不是人类病毒

引起大流行的病毒,首先它必须能够轻松地在人与人之间传播。但首次于2012年在沙特发现的MERS冠状病毒,主要是一种动物病毒。它被认为起源于蝙蝠,偶尔通过动物间(可能是骆驼)跳到人类。该病毒可偶尔在人与人之间传播,就如正在发生在韩国的情况,但只在医院环境下(详细信息在下文),或程度小得多的家庭内传播(因人们照顾感染者,有过密切接触)。目前的感染的诱发,是通过5月4日68岁的韩国男子在参观四个中东国家后飞回了韩国汉城。他被确诊之前,他将病毒传播给他被诊治过的四个不同的医疗机构的卫生保健工作者,其他病人和家庭成员。想要变成大流行,MERS冠状病毒需要发生变异,使其可以很容易地在人与人之间更广泛的传播。但根据流行病学资料显示,在韩国的这次爆发并非是不寻常的。

MERS主要传播于医院内

虽然MERS冠状病毒不被认为是人类的病毒,但有一个地方,它会表现得像人类病毒——医院。在这环境中,对未确诊的患者的进行的医疗程序,例如辅助呼吸,可以产生病毒肺气雾剂,污染区域并感染附近的人。不然的话,像MERS冠状病毒一般感染的是肺的深层区域,是不会咳出。此次爆发中,感染源于5月11日出现流感样症状并咳嗽,但在5月20日才确定诊断和隔离。这创造了一个时间窗口。在此期间,无对特殊感染采取任何防范措施,也解释了他是如何传播感染。他在确诊之前曾在四个不同的医疗机构治疗,也为感染爆发带来成倍的风险。

韩国采取的措施到位

因为它传播在人之间传播能力差,MERS冠状病毒可以通过公共健康措施被控制。韩国当局正在谋求进行积极控制。当局一直在追查感染者的接触者并进行14天透彻的监视(14天是疾病的最长潜伏期)。开始出现症状的任何人将被隔离。到目前为止,所有新发病例都处于接触者的名单中。这为疫情的控制增加了信心。每天都有新的病例报告,但这些并不代表病毒的任何新的蔓延。

MERS不是SARS

在过去的一周,一些人可能会警惕是否严重急性呼吸系统综合症(SARS)又回来。SARS虽然最终被控制住,但它与MERS有一个主要的不同:导致SARS的冠状病毒已经发展了很容易在人与人之间传播的能力。相比之下MERS冠状病毒并没有。那MERS冠状病毒是否会进化,引起SARS样的爆发?答案是病毒是不可预测的,所以这种可能性不能被排除,但也不是必然的。在这样的感染爆发下,病毒会被例行进行测序,以寻找任何基因改变。但考虑到在韩国爆发的格局没有什么超出控制的蔓延,那就没有必要做延伸假设。如果感染密集爆发在韩国医院环境之外,这将是一个严重报警。

这次爆发并不大

此爆发可能是中东以外最大的爆发,但也并不是特别例外的爆发大小。2014年春季期间在在沙特阿拉伯吉达MERS爆发造成255人被感染,2013年在在沙特阿拉伯东部哈萨医院集体爆发感染,造成23证实,11例疑似病例。沙特其他几十个医院也出现爆发,促使卫生部门培训医院员工队伍控制感染。

原始出处:

Declan Butler.South Korean MERS outbreak is not a global threat.Nature, June 8, 2015.

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    2016-01-26 doctording1

    这篇文章有一定深度

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=59826, encodeId=517a59826d9, content=这篇文章有一定深度, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Tue Jan 26 16:57:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59827, encodeId=5feb5982e8d, content=是一篇不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Tue Jan 26 16:57:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1878112, encodeId=b4cb18e811298, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Fri Oct 09 22:28:00 CST 2015, time=2015-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1880690, encodeId=bfda188069085, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Sep 14 20:28:00 CST 2015, time=2015-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=27894, encodeId=d08e2e894e7, content=呵呵, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150526/IMG5564536F3C41D5237.jpg, createdBy=4c0c1612254, createdName=summer474cn, createdTime=Wed Jun 17 08:41:00 CST 2015, time=2015-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=27783, encodeId=be6f2e78383, content=是不是sars不好说啊!, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4f0d1608613, createdName=jxsrdw, createdTime=Tue Jun 16 12:22:00 CST 2015, time=2015-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338423, encodeId=f138133842314, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Thu Jun 11 00:28:00 CST 2015, time=2015-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26932, encodeId=638c26932ad, content=疾控中心忙啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9e0b1603164, createdName=lovejing, createdTime=Wed Jun 10 19:58:00 CST 2015, time=2015-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26667, encodeId=59e92666e14, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Tue Jun 09 19:11:00 CST 2015, time=2015-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26553, encodeId=6483265537e, content=人类自己糊弄自己, beContent=null, objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150526/IMG5564536F3C41D5237.jpg, createdBy=4c0c1612254, createdName=summer474cn, createdTime=Tue Jun 09 16:04:00 CST 2015, time=2015-06-09, status=1, ipAttribution=)]
    2016-01-26 doctording1

    是一篇不错的文章

    0

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    2015-10-09 仁者大医
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    2015-09-14 liye789132251
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    2015-06-17 summer474cn

    呵呵

    0

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    2015-06-16 jxsrdw

    是不是sars不好说啊!

    0

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  8. [GetPortalCommentsPageByObjectIdResponse(id=59826, encodeId=517a59826d9, content=这篇文章有一定深度, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Tue Jan 26 16:57:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59827, encodeId=5feb5982e8d, content=是一篇不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Tue Jan 26 16:57:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1878112, encodeId=b4cb18e811298, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Fri Oct 09 22:28:00 CST 2015, time=2015-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1880690, encodeId=bfda188069085, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Sep 14 20:28:00 CST 2015, time=2015-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=27894, encodeId=d08e2e894e7, content=呵呵, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150526/IMG5564536F3C41D5237.jpg, createdBy=4c0c1612254, createdName=summer474cn, createdTime=Wed Jun 17 08:41:00 CST 2015, time=2015-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=27783, encodeId=be6f2e78383, content=是不是sars不好说啊!, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4f0d1608613, createdName=jxsrdw, createdTime=Tue Jun 16 12:22:00 CST 2015, time=2015-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338423, encodeId=f138133842314, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Thu Jun 11 00:28:00 CST 2015, time=2015-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26932, encodeId=638c26932ad, content=疾控中心忙啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9e0b1603164, createdName=lovejing, createdTime=Wed Jun 10 19:58:00 CST 2015, time=2015-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26667, encodeId=59e92666e14, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Tue Jun 09 19:11:00 CST 2015, time=2015-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26553, encodeId=6483265537e, content=人类自己糊弄自己, beContent=null, objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150526/IMG5564536F3C41D5237.jpg, createdBy=4c0c1612254, createdName=summer474cn, createdTime=Tue Jun 09 16:04:00 CST 2015, time=2015-06-09, status=1, ipAttribution=)]
    2015-06-10 lovejing

    疾控中心忙啊

    0

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    2015-06-09 huaxipanxing

    看看

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=59826, encodeId=517a59826d9, content=这篇文章有一定深度, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Tue Jan 26 16:57:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59827, encodeId=5feb5982e8d, content=是一篇不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Tue Jan 26 16:57:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1878112, encodeId=b4cb18e811298, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Fri Oct 09 22:28:00 CST 2015, time=2015-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1880690, encodeId=bfda188069085, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Sep 14 20:28:00 CST 2015, time=2015-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=27894, encodeId=d08e2e894e7, content=呵呵, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150526/IMG5564536F3C41D5237.jpg, createdBy=4c0c1612254, createdName=summer474cn, createdTime=Wed Jun 17 08:41:00 CST 2015, time=2015-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=27783, encodeId=be6f2e78383, content=是不是sars不好说啊!, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4f0d1608613, createdName=jxsrdw, createdTime=Tue Jun 16 12:22:00 CST 2015, time=2015-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338423, encodeId=f138133842314, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Thu Jun 11 00:28:00 CST 2015, time=2015-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26932, encodeId=638c26932ad, content=疾控中心忙啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9e0b1603164, createdName=lovejing, createdTime=Wed Jun 10 19:58:00 CST 2015, time=2015-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26667, encodeId=59e92666e14, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Tue Jun 09 19:11:00 CST 2015, time=2015-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26553, encodeId=6483265537e, content=人类自己糊弄自己, beContent=null, objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150526/IMG5564536F3C41D5237.jpg, createdBy=4c0c1612254, createdName=summer474cn, createdTime=Tue Jun 09 16:04:00 CST 2015, time=2015-06-09, status=1, ipAttribution=)]
    2015-06-09 summer474cn

    人类自己糊弄自己

    0

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5日从中国疾病预防控制中心获悉,中国疾控中心病毒病所与广东省及惠州市疾控中心合作,已完成我国首例输入性中东呼吸综合征(MERS)病例的病毒全基因组序列测定。据了解,5月29日1点40分,病毒病所收到广东省疾控中心送检的病例咽拭子标本,5点40分完成核酸检测。6月3日凌晨,采用高通量测序方法,完成了全基因组序列测定,并于当天上传至美国国家生物技术信息中心(GenBank)数据库。序列分析结果表明,该

1分钟看懂MERS(图)

(本文作者:中南大学湘雅医学院麻醉1302班 钟娇娇;原文标题:湖南一医学生手绘漫画:1分钟看懂MERS(图))

从SARS到MERS 他们从未改变

5月29日,国家卫生计生委对外通报,中国出现首例中东呼吸综合征(MERS)确诊病例,系输入性病例。该病例系一名韩国男性,曾与韩国MERS病例密切接触,21日在韩国境内出现不适,26日乘飞机抵达香港,经深圳沙头角口岸入境到达惠州。这是中国确认首例“新非典”病例。 国家卫计委已指导广东省卫计委按照预案开展工作,并派出专家组赴当地指导协助应急处置,并组织专家开展风险评估,研判疫情形势。截至目前,

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