MNFR：肠道微生物如何引发心脏病？

2016-08-14 佚名生物谷

在过去5年里，有些科学家提醒不要吃鸡蛋和肉，因为这些食物会产生一种常见的名为氧化三甲胺(TMAO)的膳食化合物，这种化合物在心脏疾病中扮演着重要角色。近日，一项刊登于国际杂志Molecular Nutrition and Food Research上的研究报告中，研究者就提出了新的疑问，即是否机体中循环的TMAO可以引发心脏疾病，以及是否TMAO可以作为疾病发生的一种生物标志物。在过去5年

在过去5年里，有些科学家提醒不要吃鸡蛋和肉，因为这些食物会产生一种常见的名为氧化三甲胺(TMAO)的膳食化合物，这种化合物在心脏疾病中扮演着重要角色。近日，一项刊登于国际杂志Molecular Nutrition and Food Research上的研究报告中，研究者就提出了新的疑问，即是否机体中循环的TMAO可以引发心脏疾病，以及是否TMAO可以作为疾病发生的一种生物标志物。

鱼类中TMAO的水平较高，而在人类中，被称之为厚壁菌门的肠道细菌可以将鸡蛋中的营养胆碱及肉类中的肉碱转化成为TMAO；这项研究中，研究者发现，摄入鸡蛋和牛肉后机体TMAO水平升高的健康男性同时机体中也含有较高水平的厚壁菌门细菌。研究者Marie Caudill教授说道，本文研究中我们发现，个体的肠道微生物组会影响机体中循环的TMAO的水平，然而TMAO在疾病进展过程中扮演着重要角色，为此，我们就想知道是否肠道微生物组也在疾病进展过程是否发挥着重要作用，而不光是对TMAO产生影响。

2011年，有研究者就通过研究对心血管疾病患者的血液进行分析，结果发现，患者机体中含有较高水平的循环TMAO，接下来的研究结果表明TMAO也参与到了小鼠动脉斑块的形成过程中；同时此前研究还表明，癌症早期出现5年之前，患结肠癌的女性患者机体中的就已经积累了较高水平的TMAO；因此越来越多的研究证据就提醒人们少吃鱼类、鸡蛋和肉类。

研究者想知道，虽然多年的研究都表明大量摄入鱼类可以帮助降低心脏病，但TMAO是否是心脏疾病的致病因子呢？当前研究中，研究者Caudill及其同事对40名健康年轻男性进行了饮食试验，研究者让这些参与者摄入四种不同的饮食，包括：鱼类（6盎司鳕鱼）、鸡蛋（三个煮熟的鸡蛋）、肉类（6盎司牛肉饼），同时以水果组（苹果酱）作为对照；研究对象每天随机摄入其中一种饮食方式，为期一周，在每以餐前，研究者都会收集参与者的粪便来分析其肠道微生物的组成情况，同时收集血液和尿液来测定TMAO的水平，随后研究者在餐后6小时收集参与者的血液和尿液，并测定TMAO的水平。

研究结果表明，摄入肉类和鸡蛋后机体中TMAO水平升高的男性往往肠道中的厚壁菌门细菌水平较高，而TMAO水平较低个体机体中名为bacteriodides的一类细菌的水平较高；厚壁菌门细菌可以表达出将鸡蛋中胆碱和牛肉中肉碱转化为TMAO的基因，这样就可以帮助机体产生TMAO，然而较高水平TMAO的个体机体中肠道微生物组的多样性往往较低。相比摄入鸡蛋和牛肉的男性而言，当个体摄入鱼类后，其机体中TMAO的水平在15分钟内就会增加50倍，但在美国，鱼类并不是人们日常生活中的主要饮食组成部分，人们摄入的鸡蛋和肉类更多一些。

研究者Caudill说道，本文研究表明，TMAO水平的增加或许仅仅就是区分个体肠道微生物组差异的生物标志物，我们推测，患病个体（比如癌症、心脏病和其它慢性疾病）相比健康个体而言机体中有着完全不同的肠道微生物组，而且这些微生物组可以通过血液中的TMAO水平来标记。

未来研究中，研究者将检测肠道微生物组在心脏病发病过程中所扮演的角色，并且寻找一定方法来降低机体中循环的TMAO水平，同时观察是否降低TMAO的水平可以帮助降低个体心脏病的发病风险。

原始出处：

Clara E. Cho, Siraphat Taesuwan, Olga V. Malysheva, Erica Bender, Nathan F. Tulchinsky, Jian Yan, Jessica L. Sutter, Marie A. Caudill.Trimethylamine-N-oxide (TMAO) response to animal source foods varies among healthy young men and is influenced by their gut microbiota composition: A randomized controlled trial.MNFR.2016

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2016-11-01 wjcjjian

#微生物#

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2016-09-25 1e10c84am36(暂无匿称)

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2016-09-23 1e10c84am36(暂无匿称)

文章不错，继续学习

79 0
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2016-09-13 kuangtiantian8384

神奇！

76 0
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2016-09-08 lhl629

学习学习，，，

77 0
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2016-09-05 李东泽

很好，不错，以后会多学习

99 0
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2016-08-28 1771ae4158m

这个有意思，好

68 0
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2016-08-26 ylzr123

深度好文，赞一个！!！

37 0
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2016-08-25 摩天轮

有意思的研究

61 0
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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Mon Aug 22 21:13:00 CST 2016, time=2016-08-22, status=1, ipAttribution=)]
2016-08-22 医路开来

学习啦。。。

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