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JAHA:心血管低风险人群24小时中心脉压对心血管事件的预测分析!

2018-02-26 xing.T MedSci原创

由此可见。24小时中心脉压能改善心血管低风险高血压患者的心血管事件预测。

中心血压(BP)是一种很有前景的心血管疾病风险评估指标。在识别心血管高危人群中显著优于传统的危险因素,但对于心血管低风险患者却知之甚少,尽管在这一人群中,中心和外周血压(放大)之间的差异通常更大。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,这项研究的目的是评估24小时内中心血压对心血管低风险的高血压患者心血管事件预测的影响。

研究人员记录了心血管低风险(系统的冠心病的风险评估≤5%)的高血压患者在临床随访和超过24小时的中心和外周血压。该研究的主要终点是在随访期间发生的心血管事件。为了评估24小时内中心脉压的潜在好处,研究人员采用了Cox比例风险模型分析,并用对比度测试法分析了外周和中心血压的曲线下面积。

该研究纳入了来自波尔多的703名高血压患者。在血压测量的最初24小时后,受试者平均随访112.5±70个月。随访期间研究人员记录到了65次心血管事件。当将外周24小时脉压加入分析时,研究人员发现中心血压与心血管事件显著相关(P=0.0259)。24小时中心脉压曲线下面积明显大于诊室血压曲线下面积(P=0.0296),且相比于外周24小时脉压曲线下面积有明显的优势。

由此可见。24小时中心脉压能改善心血管低风险高血压患者的心血管事件预测。

原始出处:


Antoine Cremer,et al. Twenty‐Four‐Hour Central Pulse Pressure for Cardiovascular Events Prediction in a Low‐Cardiovascular‐Risk Population: Results From the Bordeaux Cohort.JAHA.2018. https://doi.org/10.1161/JAHA.117.008225

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    2018-06-29 chengjn
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    2018-02-28 zhaohui6731

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