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Lancet:新冠肺炎疫情期间需警惕儿童川崎病风险

2020-06-06 MedSci原创 MedSci原创

新冠肺炎流行期间,意大利Bergamo地区的川崎病的发病率增加了30倍,且疫情期间患儿的年龄较大,心脏受累率较高并有巨噬细胞活化综合征特征。

意大利Bergamo是严重急性呼吸综合征冠状病毒2(SARS-CoV-2)流行的重灾区, 在过去的一个月里,该地区出现了川崎病集中爆发的现象,近日研究人员评估在SARS-CoV-2流行期间川崎样疾病的发病率和特征。
 
根据SARS-CoV-2开始流行之前(1组)或之后(2组)的症状表现,将该地区近5年来诊断为川崎样疾病的所有患者分为两组。川崎病及川崎样表现根据美国心脏协会指标,川崎病休克综合征(KDSS)定义为循环功能障碍,依据儿科风湿病国际试验组织标准定义巨噬细胞活化综合征(MAS)。鼻咽拭子和口咽拭子采样进行逆转录酶定量PCR测定,血清学检测SARS-CoV-2IgM和IgG。
 
第1组包括19名患者(7名男孩,12名女孩;年龄3.0岁),诊断时间为2015年1月1日至2020年2月17日。第二组包括2020年2月18日至4月20日确诊的10名患者(7名男孩,3名女孩;年龄7.5岁),其中8名患者IgG或IgM阳性或两者均阳性。两组在发病率(1组vs 2组,每月0.3 vs 10)、平均年龄(3.0 vs 7.5岁)、心脏受累(2/19 vs 6/10)、KDSS(0/19 vs 5/10),MAS(0/19 vs 5/10)以及需要辅助类固醇治疗(3/19例vs 8/10例)均存在显著差异。
 
研究认为,在新冠肺炎流行期间,意大利Bergamo地区的川崎病的发病率增加了30倍,且疫情期间患儿的年龄较大,心脏受累率较高并有巨噬细胞活化综合征特征。
 
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    2021-03-09 ms9000001224164167

    确实,疫情影响了很多川崎病患儿的就诊

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=946732, encodeId=b0bf946e32e1, content=确实,疫情影响了很多川崎病患儿的就诊, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1da25459754, createdName=ms9000001224164167, createdTime=Tue Mar 09 10:59:27 CST 2021, time=2021-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=813707, encodeId=656f813e0756, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64245268311, createdName=14818eb4m67暂无昵称, createdTime=Thu Aug 27 07:55:01 CST 2020, time=2020-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1830674, encodeId=676118306e4ca, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Thu Apr 08 14:45:17 CST 2021, time=2021-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028137, encodeId=4b38102813e25, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Sat Jun 06 12:45:17 CST 2020, time=2020-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1033818, encodeId=346c10338187d, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Sat Jun 06 12:45:17 CST 2020, time=2020-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=601581, encodeId=318160158147, content=<a href='/topic/show?id=30f04e8389a' target=_blank style='color:#2F92EE;'>#川崎病#</a>确切的说应该是川崎样疾病,又称为多系统炎症综合症,目前这个疾病和新冠肺炎之间的关系还不是特别确切。, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47838, encryptionId=30f04e8389a, topicName=川崎病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Jun 06 10:43:40 CST 2020, time=2020-06-06, status=1, ipAttribution=)]
    2020-08-27 14818eb4m67暂无昵称

    学习了

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=946732, encodeId=b0bf946e32e1, content=确实,疫情影响了很多川崎病患儿的就诊, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1da25459754, createdName=ms9000001224164167, createdTime=Tue Mar 09 10:59:27 CST 2021, time=2021-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=813707, encodeId=656f813e0756, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64245268311, createdName=14818eb4m67暂无昵称, createdTime=Thu Aug 27 07:55:01 CST 2020, time=2020-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1830674, encodeId=676118306e4ca, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Thu Apr 08 14:45:17 CST 2021, time=2021-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028137, encodeId=4b38102813e25, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Sat Jun 06 12:45:17 CST 2020, time=2020-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1033818, encodeId=346c10338187d, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Sat Jun 06 12:45:17 CST 2020, time=2020-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=601581, encodeId=318160158147, content=<a href='/topic/show?id=30f04e8389a' target=_blank style='color:#2F92EE;'>#川崎病#</a>确切的说应该是川崎样疾病,又称为多系统炎症综合症,目前这个疾病和新冠肺炎之间的关系还不是特别确切。, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47838, encryptionId=30f04e8389a, topicName=川崎病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Jun 06 10:43:40 CST 2020, time=2020-06-06, status=1, ipAttribution=)]
    2021-04-08 howi
  4. [GetPortalCommentsPageByObjectIdResponse(id=946732, encodeId=b0bf946e32e1, content=确实,疫情影响了很多川崎病患儿的就诊, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1da25459754, createdName=ms9000001224164167, createdTime=Tue Mar 09 10:59:27 CST 2021, time=2021-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=813707, encodeId=656f813e0756, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64245268311, createdName=14818eb4m67暂无昵称, createdTime=Thu Aug 27 07:55:01 CST 2020, time=2020-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1830674, encodeId=676118306e4ca, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Thu Apr 08 14:45:17 CST 2021, time=2021-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028137, encodeId=4b38102813e25, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Sat Jun 06 12:45:17 CST 2020, time=2020-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1033818, encodeId=346c10338187d, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Sat Jun 06 12:45:17 CST 2020, time=2020-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=601581, encodeId=318160158147, content=<a href='/topic/show?id=30f04e8389a' target=_blank style='color:#2F92EE;'>#川崎病#</a>确切的说应该是川崎样疾病,又称为多系统炎症综合症,目前这个疾病和新冠肺炎之间的关系还不是特别确切。, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47838, encryptionId=30f04e8389a, topicName=川崎病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Jun 06 10:43:40 CST 2020, time=2020-06-06, status=1, ipAttribution=)]
    2020-06-06 公卫新人

    新冠肺炎,疫情何时才能消失

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=946732, encodeId=b0bf946e32e1, content=确实,疫情影响了很多川崎病患儿的就诊, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1da25459754, createdName=ms9000001224164167, createdTime=Tue Mar 09 10:59:27 CST 2021, time=2021-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=813707, encodeId=656f813e0756, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64245268311, createdName=14818eb4m67暂无昵称, createdTime=Thu Aug 27 07:55:01 CST 2020, time=2020-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1830674, encodeId=676118306e4ca, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Thu Apr 08 14:45:17 CST 2021, time=2021-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028137, encodeId=4b38102813e25, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Sat Jun 06 12:45:17 CST 2020, time=2020-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1033818, encodeId=346c10338187d, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Sat Jun 06 12:45:17 CST 2020, time=2020-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=601581, encodeId=318160158147, content=<a href='/topic/show?id=30f04e8389a' target=_blank style='color:#2F92EE;'>#川崎病#</a>确切的说应该是川崎样疾病,又称为多系统炎症综合症,目前这个疾病和新冠肺炎之间的关系还不是特别确切。, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47838, encryptionId=30f04e8389a, topicName=川崎病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Jun 06 10:43:40 CST 2020, time=2020-06-06, status=1, ipAttribution=)]
    2020-06-06 goodbing

    顶刊就是不一样,质量很高,内容精彩!学到很多

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=946732, encodeId=b0bf946e32e1, content=确实,疫情影响了很多川崎病患儿的就诊, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1da25459754, createdName=ms9000001224164167, createdTime=Tue Mar 09 10:59:27 CST 2021, time=2021-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=813707, encodeId=656f813e0756, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64245268311, createdName=14818eb4m67暂无昵称, createdTime=Thu Aug 27 07:55:01 CST 2020, time=2020-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1830674, encodeId=676118306e4ca, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Thu Apr 08 14:45:17 CST 2021, time=2021-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1028137, encodeId=4b38102813e25, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Sat Jun 06 12:45:17 CST 2020, time=2020-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1033818, encodeId=346c10338187d, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Sat Jun 06 12:45:17 CST 2020, time=2020-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=601581, encodeId=318160158147, content=<a href='/topic/show?id=30f04e8389a' target=_blank style='color:#2F92EE;'>#川崎病#</a>确切的说应该是川崎样疾病,又称为多系统炎症综合症,目前这个疾病和新冠肺炎之间的关系还不是特别确切。, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47838, encryptionId=30f04e8389a, topicName=川崎病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Jun 06 10:43:40 CST 2020, time=2020-06-06, status=1, ipAttribution=)]
    2020-06-06 lovetcm

    #川崎病#确切的说应该是川崎样疾病,又称为多系统炎症综合症,目前这个疾病和新冠肺炎之间的关系还不是特别确切。

    0

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