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PLoS One:一个预测猪链球菌听力损失风险的评分系统

2020-02-15 AlexYang MedSci原创

猪链球菌(S.suis)病是一种新兴的人畜共患疾病,并且在南亚患病率较高。在全球范围内已经报道了超过1500个案例,主要分布在泰国,其次是越南。该疾病能够导致人类脑膜炎,最常见的患者并发症为感觉神经性听力损失(SNHL)。早期的诊断和治疗对预防严重的神经并发症是非常重要的。最近,有研究人员开发了一个易用的风险评分系统来促进可能发展为听力损失患者的S.suis的早期诊断。研究数据来源于13年的S.s

猪链球菌(S.suis)病是一种新兴的人畜共患疾病,并且在南亚患病率较高。在全球范围内已经报道了超过1500个案例,主要分布在泰国,其次是越南。该疾病能够导致人类脑膜炎,最常见的患者并发症为感觉神经性听力损失(SNHL)。早期的诊断和治疗对预防严重的神经并发症是非常重要的。

最近,有研究人员开发了一个易用的风险评分系统来促进可能发展为听力损失患者的S.suis的早期诊断。研究数据来源于13年的S.suis患者记录,并利用了单变量和多变量逻辑回归开发了一个预测模型。研究人员利用显著的预测因子系数构建了临床风险评分,还使用操作者特征曲线下面积(AuROC)来鉴定模型区分能力。研究共包括了133名患者,听力损失的发生率为31.6%(n=42)。S.suis听力损失的显著预测因子包括脑膜炎、生肉消费和眩晕。预测评分范围为0-4,修正后鉴定出81.95%的患者处于S.suis听力损失风险中。他们的模型表现出了良好的预测能力(AuROC: 0.859; 95%CI 0.785-0.933)和校准能力(AuROC: 0.860; 95%CI 0.716-0.953)。

最后,研究人员指出,他们的风险评分系统是首个为S.suis听力损失开发的系统。研究人员也指出了需要进一步的研究来优化评分系统并在推荐临床使用之前调查其外部有效性。

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    2020-02-17 ysjykql
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    2020-02-17 muzishouyi
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