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Lancet Infect Dis：特鲁瓦达或可有效预防HIV感染

2014-07-25 伊文 生物谷

特鲁瓦达HIV感染预防避孕套
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用于预防个体患高风险艾滋（AIDS）病毒感染的HIV治疗药片特鲁瓦达频频传来好消息，本周二，在澳大利亚墨尔本国际艾滋病大会上研究者们就讨论了HIV治疗药片特鲁瓦达的功效，研究人员表示，一系列的跟踪研究调查表明，HIV治疗药片的确具有明显的功效，但研究者并不鼓励进行风险性的性行为，如果风险个体偶尔错过服药的话该药物也可以维持有效的机制。 相关研究成果刊登于国际杂志Lancet&nb

用于预防个体患高风险艾滋（AIDS）病毒感染的HIV治疗药片特鲁瓦达频频传来好消息，本周二，在澳大利亚墨尔本国际艾滋病大会上研究者们就讨论了HIV治疗药片特鲁瓦达的功效，研究人员表示，一系列的跟踪研究调查表明，HIV治疗药片的确具有明显的功效，但研究者并不鼓励进行风险性的性行为，如果风险个体偶尔错过服药的话该药物也可以维持有效的机制。

相关研究成果刊登于国际杂志Lancet Infectious Diseases上；该项研究中涉及1600名同性恋男性个体及变性妇女，其均参与了最初的研究，结果显示，每天服用药物特鲁瓦达可以明显降低其感染HIV的风险。

在随后17个月的研究中药物特鲁瓦达对这些参与者免费服用，其中有四分之三的个体坚持服药。一周中至少4天服药的个体几乎不会被HIV感染，而一周2天或者3天服药的个体相比服药时间更短的个体来讲感染风险较低；研究人员会根据患者血液样本的检测结果来告知患者是否需要服药。

艾滋病专家Robert Grant 博士表示，我们对于目前的研究结果非常满意，也深受鼓舞；避孕套目前依然是预防HIV感染的主要措施，但是并不是所有人总会使用安全套，因此卫生官员就会表示，是否针对同性恋男性会有别的措施。而有些卫生官员也会担心是否目前药物特鲁瓦达会给人带来一些虚假的安全感，从而导致这些个体很少使用安全套。

原始出处：


Prof Robert M Grant MD a b c , Prof Peter L Anderson PharmD d, Vanessa McMahan BSc a, Albert Liu MD b e, K Rivet Amico PhD f, Megha Mehrotra MPH a, Sybil Hosek PhD g, Carlos Mosquera MD h, Martin Casapia MD i, Orlando Montoya j, Susan Buchbinder MD b e, Valdilea G Veloso MD k, Prof Kenneth Mayer MD l, Prof Suwat Chariyalertsak MD m, Prof Linda-Gail Bekker PhD n, Esper G Kallas MD o, Prof Mauro Schechter MD p, Juan Guanira MD h, Lane Bushman BChem d, David N Burns MD q, James F Rooney MD r, Prof David V Glidden PhD b, for the iPrEx study team.Uptake of pre-exposure prophylaxis, sexual practices, and HIV incidence in men and transgender women who have sex with men: a cohort study.The Lancet Infectious Diseases, Early Online Publication, 22 July 2014.doi:10.1016/S1473-3099(14)70847-3.


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    2014-12-26 ms6832696159214430

    #特鲁瓦达#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1798073, encodeId=27ff1e980737e, content=<a href='/topic/show?id=5ae9680603f' target=_blank style='color:#2F92EE;'>#特鲁瓦达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68060, encryptionId=5ae9680603f, topicName=特鲁瓦达)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cb02500048, createdName=ms6832696159214430, createdTime=Fri Dec 26 12:39:00 CST 2014, time=2014-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1827850, encodeId=cd99182e850f0, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Tue Sep 16 23:39:00 CST 2014, time=2014-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2011905, encodeId=505e201190513, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sat Sep 13 22:39:00 CST 2014, time=2014-09-13, status=1, ipAttribution=)]
    2014-09-16 howi

    #Lancet#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1798073, encodeId=27ff1e980737e, content=<a href='/topic/show?id=5ae9680603f' target=_blank style='color:#2F92EE;'>#特鲁瓦达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68060, encryptionId=5ae9680603f, topicName=特鲁瓦达)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cb02500048, createdName=ms6832696159214430, createdTime=Fri Dec 26 12:39:00 CST 2014, time=2014-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1827850, encodeId=cd99182e850f0, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Tue Sep 16 23:39:00 CST 2014, time=2014-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2011905, encodeId=505e201190513, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sat Sep 13 22:39:00 CST 2014, time=2014-09-13, status=1, ipAttribution=)]
    2014-09-13 cmj8wellington

    #Dis#

    0

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