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JACC:家族性高胆固醇血症在年轻心梗患者中常见

2019-05-21 不详 MedSci原创

在美国年轻时经历心肌梗死(MI)的成年人中,关于家族性高胆固醇血症(FH)的患病率和治疗的数据有限。本研究纳入了YOUNG-MI注册数据库中的首发MI年龄小于50岁的患者,家族性高胆固醇血症的诊断根据荷兰脂质诊所标准。最终,共纳入了1996名患者,平均年龄为45岁,女性占19%,54%患者有ST段抬高型心梗,有180名(9%)患者诊断为FH。89.4%的FH患者和89.9%的非FH患者出院时接受有

在美国年轻时经历心肌梗死(MI)的成年人中,关于家族性高胆固醇血症(FH)的患病率和治疗的数据有限。

本研究纳入了YOUNG-MI注册数据库中的首发MI年龄小于50岁的患者,家族性高胆固醇血症的诊断根据荷兰脂质诊所标准。最终,共纳入了1996名患者,平均年龄为45岁,女性占19%,54%患者有ST段抬高型心梗,有180名(9%)患者诊断为FH。89.4%的FH患者和89.9%的非FH患者出院时接受有他汀类药物治疗(p = 0.82)。在FH患者中,有63.3%患者出院后接受有高强度他汀类药物治疗,而非FH患者中只有48.4%(p < 0.001)。经过1年时间随访后,FH患者和非FH患者的低密度脂蛋白胆固醇(LDL-C)减少量分别为44.4%和34.5%(p = 0.006)。另外, LDL-C ≥70 mg/dl所占比例在FH患者中明显高于非FH患者( p < 0.001)。

研究结果显示,在年轻时有心梗的患者中,近十分之一患者有家族性高胆固醇血症,仅三分之二的FH患者出院后接受有高强度他汀类药物治疗。

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    2020-01-21 hbwxf
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    2019-05-23 wetgdt
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    2019-05-21 天地飞扬

    学习了,谢谢分享!

    0

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