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Crit Care Med:体外膜氧合治疗急性失代偿性心力衰竭效果如何?

2017-05-07 MedSci MedSci原创

目前,使用静脉内-体外膜氧合治疗急性失代偿性心力衰竭(即心源性休克并发慢性心肌病)患者的长期结果尚未有报道。近期,一项发表在杂志Crit Care Med上的研究旨在描述这些患者的治疗结果并确定与死亡率相关的因素。此项研究为回顾性分析。选取三级医院ICU中125名植入静脉-体外膜氧合治疗急性失代偿性心力衰竭患者为研究对象。自2007年3月至2015年1月,105例患者在ICU中植入静脉-体外膜氧合

目前,使用静脉内-体外膜氧合治疗急性失代偿性心力衰竭(即心源性休克并发慢性心肌病)患者的长期结果尚未有报道。

近期,一项发表在杂志Crit Care Med上的研究旨在描述这些患者的治疗结果并确定与死亡率相关的因素。

此项研究为回顾性分析。选取三级医院ICU中125名植入静脉-体外膜氧合治疗急性失代偿性心力衰竭患者为研究对象。

自2007年3月至2015年1月,105例患者在ICU中植入静脉-体外膜氧合治疗急性失代偿性心力衰竭(其中67%具有主动脉内球囊泵来降低左心室负担)。这些患者的1年生存率为42%;大多数幸存者直接或转换到中央双侧离心泵,心室辅助装置或全人造心脏移植。大多数的死亡患者发生在器官衰竭后的早期。

多变量分析保留(优势比[95%CI])前体外膜氧合序贯器官衰竭评估评分超过11(3.3 [1.3-8.3])、特发性心肌病(0.4 [0.2-1])、心脏病持续时间超过2年的体外膜氧合(2.8 [1.2-6.9])、体外膜氧合血乳酸大于4 mmol / L(2.6 [1.03-6.4])作为1年死亡率的独立预测因子。只有17%的患者进行体外膜氧合术后,前体外膜氧合序贯器官衰竭评估评分超过14但是仍然存活;52%的患者分数小于7,60%的患者评分为7分以上且小于11分的患者1年后仍然存活。

此项研究表明:在105名患者中,选择静脉动脉-体外膜氧合治疗急性失代偿性心力衰竭的患者中,1年生存率为42%,但对于体外膜氧合前期患者的序贯器官功能衰竭评估评分小于11更有利于患者。对于患有急性失代偿性心力衰竭的患者,应考虑进行体外膜氧合,但选择植入的时机至关重要。

原始出处:
Dangers L, Bréchot N, et al. Extracorporeal Membrane Oxygenation for Acute Decompensated Heart Failure. Crit Care Med. 2017 May 3. doi: 10.1097/CCM.0000000000002485. 

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    2017-05-19 flysky120

    心力衰竭不好治疗长期的

    0

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level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2dD8SUAwqrufRiaKMGaaBScoAzEicJJibuu3wCIWWQxoLgS2UOBx1vsPe3faZtAiatc0pTWlS6868zZH/0, createdBy=0a231960988, createdName=胖红, createdTime=Sun May 07 17:00:41 CST 2017, time=2017-05-07, status=1, ipAttribution=)]
    2017-05-08 龙胆草

    学习了,谢谢分享

    0

  6. 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level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2dD8SUAwqrufRiaKMGaaBScoAzEicJJibuu3wCIWWQxoLgS2UOBx1vsPe3faZtAiatc0pTWlS6868zZH/0, createdBy=0a231960988, createdName=胖红, createdTime=Sun May 07 17:00:41 CST 2017, time=2017-05-07, status=1, ipAttribution=)]
    2017-05-08 1e0f8808m18(暂无匿称)

    急性失代偿性心衰,治疗新法研究,学习了。

    0

  7. 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11:53:36 CST 2017, time=2017-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580087, encodeId=ff3d158008e2b, content=<a href='/topic/show?id=fd6f265e2e5' target=_blank style='color:#2F92EE;'>#体外膜氧合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26572, encryptionId=fd6f265e2e5, topicName=体外膜氧合)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff2e16588842, createdName=ms1292405679162969, createdTime=Tue May 09 07:16:00 CST 2017, time=2017-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607482, encodeId=98a0160e4822a, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue May 09 07:16:00 CST 2017, time=2017-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=195299, encodeId=c885195299eb, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon May 08 08:01:27 CST 2017, time=2017-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=195179, encodeId=984d1951e984, content=急性失代偿性心衰,治疗新法研究,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], 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level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2dD8SUAwqrufRiaKMGaaBScoAzEicJJibuu3wCIWWQxoLgS2UOBx1vsPe3faZtAiatc0pTWlS6868zZH/0, createdBy=0a231960988, createdName=胖红, createdTime=Sun May 07 17:00:41 CST 2017, time=2017-05-07, status=1, ipAttribution=)]
    2017-05-08 天涯183

    非常好的文章,学习了,很受益

    0

  8. 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level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2dD8SUAwqrufRiaKMGaaBScoAzEicJJibuu3wCIWWQxoLgS2UOBx1vsPe3faZtAiatc0pTWlS6868zZH/0, createdBy=0a231960988, createdName=胖红, createdTime=Sun May 07 17:00:41 CST 2017, time=2017-05-07, status=1, ipAttribution=)]
    2017-05-07 明月清辉

    谢谢分享,学习了

    0

  9. 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level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2dD8SUAwqrufRiaKMGaaBScoAzEicJJibuu3wCIWWQxoLgS2UOBx1vsPe3faZtAiatc0pTWlS6868zZH/0, createdBy=0a231960988, createdName=胖红, createdTime=Sun May 07 17:00:41 CST 2017, time=2017-05-07, status=1, ipAttribution=)]
    2017-05-07 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

  10. 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11:53:36 CST 2017, time=2017-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580087, encodeId=ff3d158008e2b, content=<a href='/topic/show?id=fd6f265e2e5' target=_blank style='color:#2F92EE;'>#体外膜氧合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26572, encryptionId=fd6f265e2e5, topicName=体外膜氧合)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff2e16588842, createdName=ms1292405679162969, createdTime=Tue May 09 07:16:00 CST 2017, time=2017-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607482, encodeId=98a0160e4822a, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue May 09 07:16:00 CST 2017, time=2017-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=195299, encodeId=c885195299eb, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon May 08 08:01:27 CST 2017, time=2017-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=195179, encodeId=984d1951e984, content=急性失代偿性心衰,治疗新法研究,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Mon May 08 05:53:10 CST 2017, time=2017-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=195129, encodeId=86a31951299b, content=非常好的文章,学习了,很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Mon May 08 00:09:56 CST 2017, time=2017-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=195078, encodeId=2c931950e8bb, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sun May 07 18:01:52 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=195068, encodeId=89fe19506887, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun May 07 17:37:28 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=195062, encodeId=c200195062d5, content=学习了很多的事情, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2dD8SUAwqrufRiaKMGaaBScoAzEicJJibuu3wCIWWQxoLgS2UOBx1vsPe3faZtAiatc0pTWlS6868zZH/0, createdBy=0a231960988, createdName=胖红, createdTime=Sun May 07 17:00:41 CST 2017, time=2017-05-07, status=1, ipAttribution=)]
    2017-05-07 胖红

    学习了很多的事情

    0

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