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胃黏膜保护剂,这5点要注意 !

2016-05-24 张药师 药评中心

给手机贴膜,能防止屏幕刮伤;给胃肠道贴膜,能保护黏膜免受损害。胃黏膜保护剂硫糖铝、铝碳酸镁、枸橼酸铋钾等药物,口服后可迅速附于胃黏膜及病损表面,形成一层保护性薄膜,使局部不再受到胃酸、消化酶、药物等的侵袭,起到隔离作用,被广泛用于胃及十二指肠溃疡的治疗。受此作用机制的影响,这类药最怕以下几种情况。1时间不对硫糖铝片:餐前1小时及睡前嚼碎后服用。 枸橼酸铋钾:餐前半小时及睡前服用。本药虽不

给手机贴膜,能防止屏幕刮伤;给胃肠道贴膜,能保护黏膜免受损害。胃黏膜保护剂硫糖铝、铝碳酸镁、枸橼酸铋钾等药物,口服后可迅速附于胃黏膜及病损表面,形成一层保护性薄膜,使局部不再受到胃酸、消化酶、药物等的侵袭,起到隔离作用,被广泛用于胃及十二指肠溃疡的治疗。受此作用机制的影响,这类药最怕以下几种情况。

1时间不对

硫糖铝片:餐前1小时及睡前嚼碎后服用。
 
枸橼酸铋钾:餐前半小时及睡前服用。本药虽不属抗生素类药物,但对幽门螺旋杆菌(Hp)具有明确的杀灭作用。
 
铝碳酸镁:餐后1-2小时及睡前或胃不适时嚼碎后服用。铝碳酸镁既是一种胃黏膜保护剂,也是一种抗酸剂,能缓冲胃酸,保证胃内最适pH。因此,本药应该餐后服用。

2姿势不对

服用胃黏膜保护剂时要注意服药姿势。
 
站立时,由于药物与溃疡面接触时间短,药效不能充分发挥,所以服药后静卧半小时可减慢药物排空速度,延长药物局部作用时间,提高疗效。

3马上喝水

服用胃黏膜保护剂时,只需少量温水把药送服下去即可,半小时内不宜喝太多水。否则,刚形成的药物保护膜可能被冲掉,使其保护作用减弱。
 
如果想喝水,应在服药半小时后,等保护膜稳定或达到药物作用时间,再适量饮用。
 
服用胃黏膜保护剂前、后半小也不宜服用牛奶、碳酸饮料、咖啡和茶等。

4混用药物

胃黏膜保护剂服用前或服药后1小时内不宜服用其他药物。
 
胃黏膜保护剂,可降低H2受体拮抗剂(西咪替丁、雷尼替丁、法莫替丁)抑酸药的吸收;H2受体拮抗剂,可降低胃黏膜保护剂的疗效。
 
胃黏膜保护剂含有铝、铋、镁等金属离子,可与四环素类、喹诺酮类药物形成络合物,降低其消化道吸收。
 
胃黏膜保护剂还可降低地高辛、香豆素类抗凝药、铁制剂、脱氧胆酸等药物的吸收。
 
胃黏膜保护剂与肠溶片同服,可使肠溶片加快溶解,不应同用。

5疗程过长

枸橼酸铋钾疗程4—8周,长期大剂量服用有可能导致铋性脑病,也可能引起肾脏毒性。
 
硫糖铝、铝碳酸镁连续服用也不宜超过8周。长期服用,可发生铝蓄积和铝中度,出现骨软化症和脑病等。
 
另外,由于胃粘膜保护剂可干扰食物中脂溶性维生素(特别是维生素A)的吸收,长期服用可导致脂溶性维生缺乏。

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1931835, encodeId=ad921931835ca, content=<a href='/topic/show?id=250183421dc' target=_blank style='color:#2F92EE;'>#胃黏膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83421, encryptionId=250183421dc, topicName=胃黏膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=743d308, createdName=baoya, createdTime=Tue Oct 04 03:31:00 CST 2016, time=2016-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519971, encodeId=59ec15199e1ef, content=<a href='/topic/show?id=6ab11032506f' target=_blank style='color:#2F92EE;'>#黏膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103250, encryptionId=6ab11032506f, topicName=黏膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=057f11309297, createdName=snowpeakxu, createdTime=Thu May 26 07:31:00 CST 2016, time=2016-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87008, encodeId=81e08e008c3, content=时间很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Wed May 25 06:41:00 CST 2016, time=2016-05-25, status=1, ipAttribution=)]
    2016-10-04 baoya
  2. [GetPortalCommentsPageByObjectIdResponse(id=1931835, encodeId=ad921931835ca, content=<a href='/topic/show?id=250183421dc' target=_blank style='color:#2F92EE;'>#胃黏膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83421, encryptionId=250183421dc, topicName=胃黏膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=743d308, createdName=baoya, createdTime=Tue Oct 04 03:31:00 CST 2016, time=2016-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519971, encodeId=59ec15199e1ef, content=<a href='/topic/show?id=6ab11032506f' target=_blank style='color:#2F92EE;'>#黏膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103250, encryptionId=6ab11032506f, topicName=黏膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=057f11309297, createdName=snowpeakxu, createdTime=Thu May 26 07:31:00 CST 2016, time=2016-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87008, encodeId=81e08e008c3, content=时间很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Wed May 25 06:41:00 CST 2016, time=2016-05-25, status=1, ipAttribution=)]
    2016-05-26 snowpeakxu
  3. [GetPortalCommentsPageByObjectIdResponse(id=1931835, encodeId=ad921931835ca, content=<a href='/topic/show?id=250183421dc' target=_blank style='color:#2F92EE;'>#胃黏膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83421, encryptionId=250183421dc, topicName=胃黏膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=743d308, createdName=baoya, createdTime=Tue Oct 04 03:31:00 CST 2016, time=2016-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519971, encodeId=59ec15199e1ef, content=<a href='/topic/show?id=6ab11032506f' target=_blank style='color:#2F92EE;'>#黏膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103250, encryptionId=6ab11032506f, topicName=黏膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=057f11309297, createdName=snowpeakxu, createdTime=Thu May 26 07:31:00 CST 2016, time=2016-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87008, encodeId=81e08e008c3, content=时间很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Wed May 25 06:41:00 CST 2016, time=2016-05-25, status=1, ipAttribution=)]
    2016-05-25 milkshark

    时间很重要

    0

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