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Ann Intern Med:警惕!念珠菌:一种新型的全球性耐药真菌

2019-07-31 佚名 生物探索

念珠菌正在成为一种新型的全球性耐药真菌。

俗话说,人怕出名猪怕壮,但是真要出名也没那么容易,尤其是对一种真菌来说。

念球菌(C auris)目前正在成为一个家喻户晓的名字,不过不是什么好事。念球菌这次的出名是因为它正在逐渐成为一种新型的全球流行的耐药性真菌。

念珠菌最早在2009年日本一名患者的耳道中发现,经鉴定是一种导致血液和腹腔内感染的潜在致命真菌。此后在超过30个国家中引起侵袭性感染

C auris与以往常见的念球菌属不同,大多数念珠菌属物种不会在卫生保健机构中传播,并且当患者发生感染时也不需要采取感染控制措施。然而,与其他念珠菌属物种不同,C auris不仅能在卫生保健机构的患者之间传播,还能通过群体设备接触传播,导致群体性爆发。 这种真菌一旦染上就很难从设施中根除,因此一些医疗机构不得不引进特殊的清洁设备,甚至撕掉地板和天花板瓷砖以摆脱它。

另外,此次C auris全球流行的严峻之处在于其抗药性。超过90%的C auris感染对至少一种抗真菌药物产生抗药性,而30%的药物对两种或多种主要药物产生抗药性。

美国疾病控制和预防中心的提示,频繁住院和接受多种广谱抗生素治疗是重要的风险因素,医师应当对这些风险因素保持高度警惕并对一些患者进行适当的筛查才是控制C auris传播的关键。

原始出处:

Snigdha Vallabhaneni, et al. Candida auris: An Emerging Antimicrobial Resistance Threat. Ann Intern Med. 2019. DOI: 10.7326/M19-2205.

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