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Am J Resp Crit Care:儿童鼻病毒感染易化肺炎链球菌的感染和传播!

2017-05-11 xing.T MedSci原创

由此可见,在家庭成员中鼻病毒感染有利于肺炎链球菌的感染和家庭传播。

实验室和临床证据表明鼻病毒和肺炎链球菌在呼吸道感染的病理机制中存在协同效应。然而,目前尚不清楚鼻病毒是否会促进肺炎链球菌的得病和传播。近日,呼吸内科以及重症医学领域权威杂志Am J Resp Crit Care上发表了一篇研究文章,研究人员旨在描述在家庭儿童中鼻病毒感染对肺炎链球菌的得病和传播的影响。

研究人员调查了29个至少有两个孩子的家庭。从任何家庭成员发生呼吸道感染症状开始进行随访,包括每天症状日记和鼻拭子样本,对每个参与者一周进行两次,为期三周。拭子由家长邮寄送到研究所。研究人员采用反转录聚合酶链反应检测和通过测序来分型鼻病毒。肺炎链球菌是由抗原试验和标准的培养方法、血清型和全基因组测序来确定。研究人员使用泊松回归和观察到的得病事件来估计鼻病毒感染对肺炎链球菌得病发生情况和家庭内传播的影响。

在发病时有38例(30%)患者检测到了鼻病毒感染,在随访期间在86例(67%)患者检测到了鼻病毒。在发病第一天在9例(7%)患者中检测到了肺炎链球菌,在随访期间,38例(30%)患者检测到了肺炎链球菌。鼻病毒感染的儿童发生肺炎链球菌感染的风险增加4.3倍(95%可信区间为1.1-15.4),家庭内部传播风险增加14.8倍(95%可信区间为3.1-69.6),相比于无鼻病毒感染的儿童。

由此可见,在家庭成员中鼻病毒感染有利于肺炎链球菌的感染和家庭传播。

原始出处:

Sinikka Karppinen , et al. Acquisition and Transmission of Streptococcus pneumoniae is Facilitated During Rhinovirus Infection in Families with Children. AM J RESP CRIT CARE 2017. http://www.atsjournals.org/doi/abs/10.1164/rccm.201702-0357OC

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    2017-05-14 cuiyejia

    学习了,谢谢

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=197984, encodeId=3d0619e984c7, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28761705280, createdName=cuiyejia, createdTime=Sun May 14 12:36:33 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1443195, encodeId=70b3144319518, content=<a href='/topic/show?id=49ae8219357' target=_blank style='color:#2F92EE;'>#肺炎链球菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82193, encryptionId=49ae8219357, topicName=肺炎链球菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=69f05034104, createdName=12498e0fm79暂无昵称, createdTime=Sat May 13 12:21:00 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624043, encodeId=c92016240436c, content=<a href='/topic/show?id=69699666026' target=_blank style='color:#2F92EE;'>#链球菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96660, encryptionId=69699666026, topicName=链球菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=787f20641298, createdName=liuquanmn, createdTime=Sat May 13 12:21:00 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626593, encodeId=b0f616265935c, content=<a href='/topic/show?id=6a3b10348172' target=_blank style='color:#2F92EE;'>#鼻病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103481, encryptionId=6a3b10348172, topicName=鼻病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e59021047417, createdName=tonychen28, createdTime=Sat May 13 12:21:00 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197143, encodeId=cf5f19e143a4, content=在家庭成员中鼻病毒感染有利于肺炎链球菌的感染和家庭传播。, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Fri May 12 14:57:37 CST 2017, time=2017-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197005, encodeId=443219e0059a, content=感谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e50c2057149, createdName=xiaodayi, createdTime=Fri May 12 09:29:26 CST 2017, time=2017-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=196786, encodeId=e716196e860c, content=还需扩大样本量, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170701/IMG595791009FB761316.jpg, createdBy=abd01695121, createdName=吴教授, createdTime=Thu May 11 23:41:40 CST 2017, time=2017-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=196757, encodeId=917f196e57a1, content=这个咨询真的很有用处!, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e50c2057149, createdName=xiaodayi, createdTime=Thu May 11 21:39:05 CST 2017, time=2017-05-11, status=1, ipAttribution=)]
    2017-05-12 往日如昨

    在家庭成员中鼻病毒感染有利于肺炎链球菌的感染和家庭传播。

    0

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    2017-05-12 xiaodayi

    感谢分享!

    0

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    2017-05-11 吴教授

    还需扩大样本量

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=197984, encodeId=3d0619e984c7, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28761705280, createdName=cuiyejia, createdTime=Sun May 14 12:36:33 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1443195, encodeId=70b3144319518, content=<a href='/topic/show?id=49ae8219357' target=_blank style='color:#2F92EE;'>#肺炎链球菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82193, encryptionId=49ae8219357, topicName=肺炎链球菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=69f05034104, createdName=12498e0fm79暂无昵称, createdTime=Sat May 13 12:21:00 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624043, encodeId=c92016240436c, content=<a href='/topic/show?id=69699666026' target=_blank style='color:#2F92EE;'>#链球菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96660, encryptionId=69699666026, topicName=链球菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=787f20641298, createdName=liuquanmn, createdTime=Sat May 13 12:21:00 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626593, encodeId=b0f616265935c, content=<a href='/topic/show?id=6a3b10348172' target=_blank style='color:#2F92EE;'>#鼻病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103481, encryptionId=6a3b10348172, topicName=鼻病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e59021047417, createdName=tonychen28, createdTime=Sat May 13 12:21:00 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197143, encodeId=cf5f19e143a4, content=在家庭成员中鼻病毒感染有利于肺炎链球菌的感染和家庭传播。, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Fri May 12 14:57:37 CST 2017, time=2017-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197005, encodeId=443219e0059a, content=感谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e50c2057149, createdName=xiaodayi, createdTime=Fri May 12 09:29:26 CST 2017, time=2017-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=196786, encodeId=e716196e860c, content=还需扩大样本量, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170701/IMG595791009FB761316.jpg, createdBy=abd01695121, createdName=吴教授, createdTime=Thu May 11 23:41:40 CST 2017, time=2017-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=196757, encodeId=917f196e57a1, content=这个咨询真的很有用处!, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e50c2057149, createdName=xiaodayi, createdTime=Thu May 11 21:39:05 CST 2017, time=2017-05-11, status=1, ipAttribution=)]
    2017-05-11 xiaodayi

    这个咨询真的很有用处!

    0

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