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中国急性早幼粒细胞白血病诊疗指南（2018年版）

2018-05-24 中华医学会血液学分会

急性早幼粒细胞性白血病

急性早幼粒细胞白血病(APL)是一种特殊类型的急性髓系白血病(AML),绝大多数患者具有特异性染色体易位t(15;17) (q22;q12),形成PML-RARα融合基因,其蛋白产物导致细胞分化阻滞和凋亡不足,是APL发生的主要分子机制.APL易见于中青年人,平均发病年龄为44岁,APL占同期AML的10％～15％,发病率约0.23/10万.APL临床表现凶险,起病及诱导治疗过程中容易发生出血

中文标题：

中国急性早幼粒细胞白血病诊疗指南（2018年版）

英文标题：

Chinese guidelines for diagnosis and treatment of acute promyelocytic leukemia (2018)

发布机构：

中华医学会血液学分会

发布日期：

2018-05-24

简要介绍：

急性早幼粒细胞白血病(APL)是一种特殊类型的急性髓系白血病(AML),绝大多数患者具有特异性染色体易位t(15;17) (q22;q12),形成PML-RARα融合基因,其蛋白产物导致细胞分化阻滞和凋亡不足,是APL发生的主要分子机制.APL易见于中青年人,平均发病年龄为44岁,APL占同期AML的10％～15％,发病率约0.23/10万.APL临床表现凶险,起病及诱导治疗过程中容易发生出血和栓塞而引起死亡.近三十年来,由于全反式维甲酸(ATRA)及砷剂的规范化临床应用,APL已成为基本不用进行造血干细胞移植即可治愈的白血病.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=2205736, encodeId=7f962205e36a1, content=我怎么能看到全文, beContent=null, objectType=guider, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=edad9309026, createdName=ms3000001882866489, createdTime=Mon May 20 20:19:20 CST 2024, time=2024-05-20, status=1, ipAttribution=河南省), GetPortalCommentsPageByObjectIdResponse(id=1056024, encodeId=0f8b105602483, content=非常好, beContent=null, objectType=guider, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56545167768, createdName=146cdb0fm09暂无昵称, createdTime=Wed Sep 29 12:26:14 CST 2021, time=2021-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1007073, encodeId=3ccf100e07326, content=非常感谢, beContent=null, objectType=guider, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7de95570739, createdName=ms3000002031095801, createdTime=Wed Aug 11 21:25:35 CST 2021, time=2021-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1007072, encodeId=d95e100e07270, content=非常好, beContent=null, objectType=guider, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7de95570739, createdName=ms3000002031095801, createdTime=Wed Aug 11 21:25:19 CST 2021, time=2021-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1000005, encodeId=958e1000005cf, content=很好, beContent=null, objectType=guider, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=343e5530907, createdName=ms9000000012500818, createdTime=Fri Jul 16 12:56:15 CST 2021, time=2021-07-16, status=1, ipAttribution=)]
    2024-05-20 ms3000001882866489 来自河南省

    我怎么能看到全文

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2205736, encodeId=7f962205e36a1, content=我怎么能看到全文, beContent=null, objectType=guider, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=edad9309026, createdName=ms3000001882866489, createdTime=Mon May 20 20:19:20 CST 2024, time=2024-05-20, status=1, ipAttribution=河南省), GetPortalCommentsPageByObjectIdResponse(id=1056024, encodeId=0f8b105602483, content=非常好, beContent=null, objectType=guider, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56545167768, createdName=146cdb0fm09暂无昵称, createdTime=Wed Sep 29 12:26:14 CST 2021, time=2021-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1007073, encodeId=3ccf100e07326, content=非常感谢, beContent=null, objectType=guider, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7de95570739, createdName=ms3000002031095801, createdTime=Wed Aug 11 21:25:35 CST 2021, time=2021-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1007072, encodeId=d95e100e07270, content=非常好, beContent=null, objectType=guider, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7de95570739, createdName=ms3000002031095801, createdTime=Wed Aug 11 21:25:19 CST 2021, time=2021-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1000005, encodeId=958e1000005cf, content=很好, beContent=null, objectType=guider, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=343e5530907, createdName=ms9000000012500818, createdTime=Fri Jul 16 12:56:15 CST 2021, time=2021-07-16, status=1, ipAttribution=)]
    2021-09-29 146cdb0fm09暂无昵称

    非常好

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2205736, encodeId=7f962205e36a1, content=我怎么能看到全文, beContent=null, objectType=guider, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=edad9309026, createdName=ms3000001882866489, createdTime=Mon May 20 20:19:20 CST 2024, time=2024-05-20, status=1, ipAttribution=河南省), GetPortalCommentsPageByObjectIdResponse(id=1056024, encodeId=0f8b105602483, content=非常好, beContent=null, objectType=guider, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56545167768, createdName=146cdb0fm09暂无昵称, createdTime=Wed Sep 29 12:26:14 CST 2021, time=2021-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1007073, encodeId=3ccf100e07326, content=非常感谢, beContent=null, objectType=guider, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7de95570739, createdName=ms3000002031095801, createdTime=Wed Aug 11 21:25:35 CST 2021, time=2021-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1007072, encodeId=d95e100e07270, content=非常好, beContent=null, objectType=guider, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7de95570739, createdName=ms3000002031095801, createdTime=Wed Aug 11 21:25:19 CST 2021, time=2021-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1000005, encodeId=958e1000005cf, content=很好, beContent=null, objectType=guider, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=343e5530907, createdName=ms9000000012500818, createdTime=Fri Jul 16 12:56:15 CST 2021, time=2021-07-16, status=1, ipAttribution=)]
    2021-08-11 ms3000002031095801

    非常感谢

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2205736, encodeId=7f962205e36a1, content=我怎么能看到全文, beContent=null, objectType=guider, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=edad9309026, createdName=ms3000001882866489, createdTime=Mon May 20 20:19:20 CST 2024, time=2024-05-20, status=1, ipAttribution=河南省), GetPortalCommentsPageByObjectIdResponse(id=1056024, encodeId=0f8b105602483, content=非常好, beContent=null, objectType=guider, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56545167768, createdName=146cdb0fm09暂无昵称, createdTime=Wed Sep 29 12:26:14 CST 2021, time=2021-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1007073, encodeId=3ccf100e07326, content=非常感谢, beContent=null, objectType=guider, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7de95570739, createdName=ms3000002031095801, createdTime=Wed Aug 11 21:25:35 CST 2021, time=2021-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1007072, encodeId=d95e100e07270, content=非常好, beContent=null, objectType=guider, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7de95570739, createdName=ms3000002031095801, createdTime=Wed Aug 11 21:25:19 CST 2021, time=2021-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1000005, encodeId=958e1000005cf, content=很好, beContent=null, objectType=guider, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=343e5530907, createdName=ms9000000012500818, createdTime=Fri Jul 16 12:56:15 CST 2021, time=2021-07-16, status=1, ipAttribution=)]
    2021-08-11 ms3000002031095801

    非常好

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2205736, encodeId=7f962205e36a1, content=我怎么能看到全文, beContent=null, objectType=guider, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=edad9309026, createdName=ms3000001882866489, createdTime=Mon May 20 20:19:20 CST 2024, time=2024-05-20, status=1, ipAttribution=河南省), GetPortalCommentsPageByObjectIdResponse(id=1056024, encodeId=0f8b105602483, content=非常好, beContent=null, objectType=guider, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56545167768, createdName=146cdb0fm09暂无昵称, createdTime=Wed Sep 29 12:26:14 CST 2021, time=2021-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1007073, encodeId=3ccf100e07326, content=非常感谢, beContent=null, objectType=guider, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7de95570739, createdName=ms3000002031095801, createdTime=Wed Aug 11 21:25:35 CST 2021, time=2021-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1007072, encodeId=d95e100e07270, content=非常好, beContent=null, objectType=guider, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7de95570739, createdName=ms3000002031095801, createdTime=Wed Aug 11 21:25:19 CST 2021, time=2021-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1000005, encodeId=958e1000005cf, content=很好, beContent=null, objectType=guider, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=343e5530907, createdName=ms9000000012500818, createdTime=Fri Jul 16 12:56:15 CST 2021, time=2021-07-16, status=1, ipAttribution=)]
    2021-07-16 ms9000000012500818

    很好

    0

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