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慢性乙型肝炎临床治愈(功能性治愈)专家共识

2019-08-15 中华医学会感染病学会分会 临床肝胆病杂志,2019,35(8):1693-1701.

慢性HBV感染仍是全球重大公共卫生问题。慢性乙型肝炎(慢乙肝)临床治愈(亦称功能性治愈)即完成有限疗程治疗后,血清HBsAg和HBV DNA持续检测不到、HBeAg阴转、伴或不伴HBsAg血清学转换,肝脏炎症缓解和组织病理学改善,终末期肝病发生率显著降低,是目前国内外最新慢乙肝防治指南推荐的理想治疗目标。临床实践证明,以直接抗病毒药物(DAA)[如核苷(酸)类似物(NA)]或免疫调节剂[如聚乙二醇

中文标题:

慢性乙型肝炎临床治愈(功能性治愈)专家共识

发布日期:

2019-08-15

简要介绍:

慢性HBV感染仍是全球重大公共卫生问题。慢性乙型肝炎(慢乙肝)临床治愈(亦称功能性治愈)即完成有限疗程治疗后,血清HBsAg和HBV DNA持续检测不到、HBeAg阴转、伴或不伴HBsAg血清学转换,肝脏炎症缓解和组织病理学改善,终末期肝病发生率显著降低,是目前国内外最新慢乙肝防治指南推荐的理想治疗目标。临床实践证明,以直接抗病毒药物(DAA)[如核苷(酸)类似物(NA)]或免疫调节剂[如聚乙二醇化干扰素(PEG-IFN)α]序贯或联合治疗的优化方案针对部分优势人群显示出良好的疗效,开展了系列成功实现HBsAg阴转的多中心随机对照临床研究。《慢性乙型肝炎临床治愈(功能性治愈)专家共识》阐述了联合治疗方案的最新循证医学依据,并总结了慢乙肝临床治愈路线图,以指导临床医师治疗决策的制订。

 

拓展指南:乙型肝炎相关指南:

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1203492, encodeId=b66e120349234, content=学习学习, beContent=null, objectType=guider, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5906557239, createdName=ms8000001321195815, createdTime=Thu Mar 17 16:31:07 CST 2022, time=2022-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996517, encodeId=44a999651e20, content=学习了, beContent=null, objectType=guider, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201209/2416a2f8000f4c6f9ca86a500bff21d9/a5506367d87e4670ba4b537445ad01d5.jpg, createdBy=50cb2151142, createdName=188200f478m, createdTime=Mon Jul 05 20:29:24 CST 2021, time=2021-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=952964, encodeId=098695296432, content=非常好的建议, beContent=null, objectType=guider, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210718/fefe6467384e49b09c15bd5a914619d1/aa8483d54880438294f7e764334249cd.jpg, createdBy=e23e5270334, createdName=1481fa9cm89暂无昵称, createdTime=Wed Mar 31 23:26:00 CST 2021, time=2021-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951926, encodeId=34c895192600, content=好指南, beContent=null, objectType=guider, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9e3f5293425, createdName=1486adbfm03暂无昵称, createdTime=Sun Mar 28 21:22:20 CST 2021, time=2021-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=946938, encodeId=57a894693864, content=学习了,很实用, beContent=null, objectType=guider, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKOK08AQHJbylpsuNYNlWRgZocTYNyVGEJ6oXa4e41iahRONTxTUiaX6sMyrVC2NYNRMxuzU9XBPIgg/132, createdBy=d3262549016, createdName=TLM, createdTime=Tue Mar 09 22:29:56 CST 2021, time=2021-03-09, status=1, ipAttribution=)]
    2022-03-17 ms8000001321195815

    学习学习

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1203492, encodeId=b66e120349234, content=学习学习, beContent=null, objectType=guider, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5906557239, createdName=ms8000001321195815, createdTime=Thu Mar 17 16:31:07 CST 2022, time=2022-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996517, encodeId=44a999651e20, content=学习了, beContent=null, objectType=guider, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201209/2416a2f8000f4c6f9ca86a500bff21d9/a5506367d87e4670ba4b537445ad01d5.jpg, createdBy=50cb2151142, createdName=188200f478m, createdTime=Mon Jul 05 20:29:24 CST 2021, time=2021-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=952964, encodeId=098695296432, content=非常好的建议, beContent=null, objectType=guider, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210718/fefe6467384e49b09c15bd5a914619d1/aa8483d54880438294f7e764334249cd.jpg, createdBy=e23e5270334, createdName=1481fa9cm89暂无昵称, createdTime=Wed Mar 31 23:26:00 CST 2021, time=2021-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951926, encodeId=34c895192600, content=好指南, beContent=null, objectType=guider, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9e3f5293425, createdName=1486adbfm03暂无昵称, createdTime=Sun Mar 28 21:22:20 CST 2021, time=2021-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=946938, encodeId=57a894693864, content=学习了,很实用, beContent=null, objectType=guider, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKOK08AQHJbylpsuNYNlWRgZocTYNyVGEJ6oXa4e41iahRONTxTUiaX6sMyrVC2NYNRMxuzU9XBPIgg/132, createdBy=d3262549016, createdName=TLM, createdTime=Tue Mar 09 22:29:56 CST 2021, time=2021-03-09, status=1, ipAttribution=)]
    2021-07-05 188200f478m

    学习了

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1203492, encodeId=b66e120349234, content=学习学习, beContent=null, objectType=guider, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5906557239, createdName=ms8000001321195815, createdTime=Thu Mar 17 16:31:07 CST 2022, time=2022-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996517, encodeId=44a999651e20, content=学习了, beContent=null, objectType=guider, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201209/2416a2f8000f4c6f9ca86a500bff21d9/a5506367d87e4670ba4b537445ad01d5.jpg, createdBy=50cb2151142, createdName=188200f478m, createdTime=Mon Jul 05 20:29:24 CST 2021, time=2021-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=952964, encodeId=098695296432, content=非常好的建议, beContent=null, objectType=guider, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210718/fefe6467384e49b09c15bd5a914619d1/aa8483d54880438294f7e764334249cd.jpg, createdBy=e23e5270334, createdName=1481fa9cm89暂无昵称, createdTime=Wed Mar 31 23:26:00 CST 2021, time=2021-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951926, encodeId=34c895192600, content=好指南, beContent=null, objectType=guider, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9e3f5293425, createdName=1486adbfm03暂无昵称, createdTime=Sun Mar 28 21:22:20 CST 2021, time=2021-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=946938, encodeId=57a894693864, content=学习了,很实用, beContent=null, objectType=guider, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKOK08AQHJbylpsuNYNlWRgZocTYNyVGEJ6oXa4e41iahRONTxTUiaX6sMyrVC2NYNRMxuzU9XBPIgg/132, createdBy=d3262549016, createdName=TLM, createdTime=Tue Mar 09 22:29:56 CST 2021, time=2021-03-09, status=1, ipAttribution=)]
    2021-03-31 1481fa9cm89暂无昵称

    非常好的建议

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1203492, encodeId=b66e120349234, content=学习学习, beContent=null, objectType=guider, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5906557239, createdName=ms8000001321195815, createdTime=Thu Mar 17 16:31:07 CST 2022, time=2022-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996517, encodeId=44a999651e20, content=学习了, beContent=null, objectType=guider, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201209/2416a2f8000f4c6f9ca86a500bff21d9/a5506367d87e4670ba4b537445ad01d5.jpg, createdBy=50cb2151142, createdName=188200f478m, createdTime=Mon Jul 05 20:29:24 CST 2021, time=2021-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=952964, encodeId=098695296432, content=非常好的建议, beContent=null, objectType=guider, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210718/fefe6467384e49b09c15bd5a914619d1/aa8483d54880438294f7e764334249cd.jpg, createdBy=e23e5270334, createdName=1481fa9cm89暂无昵称, createdTime=Wed Mar 31 23:26:00 CST 2021, time=2021-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951926, encodeId=34c895192600, content=好指南, beContent=null, objectType=guider, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9e3f5293425, createdName=1486adbfm03暂无昵称, createdTime=Sun Mar 28 21:22:20 CST 2021, time=2021-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=946938, encodeId=57a894693864, content=学习了,很实用, beContent=null, objectType=guider, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKOK08AQHJbylpsuNYNlWRgZocTYNyVGEJ6oXa4e41iahRONTxTUiaX6sMyrVC2NYNRMxuzU9XBPIgg/132, createdBy=d3262549016, createdName=TLM, createdTime=Tue Mar 09 22:29:56 CST 2021, time=2021-03-09, status=1, ipAttribution=)]
    2021-03-28 1486adbfm03暂无昵称

    好指南

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1203492, encodeId=b66e120349234, content=学习学习, beContent=null, objectType=guider, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5906557239, createdName=ms8000001321195815, createdTime=Thu Mar 17 16:31:07 CST 2022, time=2022-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996517, encodeId=44a999651e20, content=学习了, beContent=null, objectType=guider, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201209/2416a2f8000f4c6f9ca86a500bff21d9/a5506367d87e4670ba4b537445ad01d5.jpg, createdBy=50cb2151142, createdName=188200f478m, createdTime=Mon Jul 05 20:29:24 CST 2021, time=2021-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=952964, encodeId=098695296432, content=非常好的建议, beContent=null, objectType=guider, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210718/fefe6467384e49b09c15bd5a914619d1/aa8483d54880438294f7e764334249cd.jpg, createdBy=e23e5270334, createdName=1481fa9cm89暂无昵称, createdTime=Wed Mar 31 23:26:00 CST 2021, time=2021-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951926, encodeId=34c895192600, content=好指南, beContent=null, objectType=guider, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9e3f5293425, createdName=1486adbfm03暂无昵称, createdTime=Sun Mar 28 21:22:20 CST 2021, time=2021-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=946938, encodeId=57a894693864, content=学习了,很实用, beContent=null, objectType=guider, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKOK08AQHJbylpsuNYNlWRgZocTYNyVGEJ6oXa4e41iahRONTxTUiaX6sMyrVC2NYNRMxuzU9XBPIgg/132, createdBy=d3262549016, createdName=TLM, createdTime=Tue Mar 09 22:29:56 CST 2021, time=2021-03-09, status=1, ipAttribution=)]
    2021-03-09 TLM

    学习了,很实用

    0

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