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New insights into long non-coding RNAs in breast cancer: Biological functions and therapeutic prospects

期刊: EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2021; 120 ()

Breast cancer (BC) has become one of the most common malignant tumors in the world, seriously endangering women's health and life. However, the underl......

PRR34-AS1 sponges miR-498 to facilitate TOMM20 and ITGA6 mediated tumor progression in HCC

期刊: EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2021; 120 ()

Background: The researches on PRR34 antisense RNA 1 (PRR34-AS1) have been limited. Both translocase of outer mitochondrial membrane 20 (TOMM20) and in......

Integrated analysis of multiple microarray studies to identify potential pathogenic gene modules in preeclampsia

期刊: EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2021; 120 ()

Background: Preeclampsia is a life-threatening hypertensive disorder during pregnancy, while underlying pathogenesis and its diagnosis are incomplete.......

MiR-93/HMGB3 regulatory axis exerts tumor suppressive effects in colorectal carcinoma cells

期刊: EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2021; 120 ()

Objective: MicroRNA (miR)-93 has been proven to mediate the initiation and progression of colorectal carcinoma (CRC); however, the mechanisms by which......

LINC00665 activates Wnt/beta-catenin signaling pathway to facilitate tumor progression of colorectal cancer via upregulating CTNNB1

期刊: EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2021; 120 ()

Background LINC00665 is a newly identified oncogene, which has been reported to be oncogene in various cancers. Nevertheless, its role in the progress......

Expression and change of miR-199b-5p, s HLA-G in thyroid carcinoma

期刊: EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2021; 120 ()

Objective: This research aims to investigate the relationship between the expression of microRNA-199b-5p (miR199b-5p) and soluble human leukocyte anti......

Long non-coding RNA muskelin 1 antisense RNA (MKLN1-AS) is a potential diagnostic and prognostic biomarker and therapeutic target for hepatocellular carcinoma

期刊: EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2021; 120 ()

Backgrounds/aims: Hepatocellular carcinoma is recognized as the most common subtype of hepatic cancer. Muskelin 1 antisense RNA (MKLN1-AS) shows progn......

LncRNA SNHG1 contributes to the cisplatin resistance and progression of NSCLC via miR-330-5p/DCLK1 axis

期刊: EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2021; 120 ()

Background: Long non-coding RNAs (lncRNAs) are involved in the occurrence and progression of multiple cancers, including non-small cell lung cancer (N......

Circ-E2F3 acts as a ceRNA for miR-204-5p to promote proliferation, metastasis and apoptosis inhibition in retinoblastoma by regulating ROCK1 expression

期刊: EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2021; 120 ()

Background: Circular RNA (circRNA) plays an important role in the malignant progression of many tumors, including retinoblastoma (RB). However, the ro......

Acquired MET amplification in non-small cell lung cancer is highly associated with the exposure of EGFR inhibitors and may not affect patients' outcome

期刊: EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2021; 118 ()

MET amplification has been associated with shorter survival in cancer patients and thought to represent one of two major mechanisms for developing res......

Targeting miR-10a-5p/IL-6R axis for reducing IL-6-induced cartilage cell ferroptosis

期刊: EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2021; 118 ()

Background: Intervertebral disc degeneration (IDD) causes lower back pain, and is often accompanied with robust inflammation. However, whether inflamm......

LncRNA CASC2 targets CAV1 by competitively binding with microRNA-194-5p to inhibit neonatal lung injury

期刊: EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2021; 118 ()

Long non-coding RNAs (lncRNAs) are vital regulators of different biological processes during bronchopulmonary dysplasia (BPD). This study was conducte......

Analysis on the expression and value of CCL2 and CCL3 in patients with osteoarthritis

期刊: EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2021; 118 ()

In this study, we investigated the clinical value of CC chemokine ligand 2 (CCL2) and CC chemokine ligand 3 (CCL3) in osteoarthritis (OA). A prospecti......

RabGEF1 functions as an oncogene in U251 glioblastoma cells and is involved in regulating AKT and Erk pathways

期刊: EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2021; 118 ()

Background: RabGEF1 is a guanine-nucleotide exchange factor for RAB-5, which plays an oncogenic role in certain human cancers. However, the function o......

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