期刊： EXPERT OPINION ON DRUG DISCOVERY, ; ()
Introduction HDACs catalyze the removal of acetyl groups from the epsilon-N-acetylated lysine residues of various protein substrates including both hi......
期刊： EXPERT OPINION ON DRUG DISCOVERY, ; ()
Introduction: Toll-like receptor (TLR) 7 and TLR8 are functionally localized to endosomes and recognize specific RNA sequences. They play crucial role......
期刊： EXPERT OPINION ON DRUG DISCOVERY, ; ()
Introduction: Cancer has been identified to be the second major cause of death internationally as exemplified by ca. 9.6 million deaths in 2018 along ......
期刊： EXPERT OPINION ON DRUG DISCOVERY, 0; ()
Introduction: MicroRNAs (miRNAs) are small endogenous non-coding RNAs that repress the expression of their target genes by reducing mRNA stability and......
期刊： EXPERT OPINION ON DRUG DISCOVERY, 2019; 14 (1)
Introduction: c-Met kinase plays an important part in the regulation of cell growth, invasion and anti-apoptosis. This enzyme is also an important tar......
期刊： EXPERT OPINION ON DRUG DISCOVERY, 2019; 14 (8)
Introduction: DNA-encoded chemical libraries (DELs) have come of age and emerged to become a powerful technology platform for ligand discovery in biom......
期刊： EXPERT OPINION ON DRUG DISCOVERY, 2019; 14 (9)
Introduction: Thrombosis is a common causal pathology for stroke, acute coronary syndrome and venous thromboembolism disorders, which are the leading ......
期刊： EXPERT OPINION ON DRUG DISCOVERY, 2019; 14 (10)
Introduction: Over the past decade, numerous research efforts have identified the gut microbiota as a novel regulator of human metabolic syndrome and ......
期刊： EXPERT OPINION ON DRUG DISCOVERY, 2019; 14 (8)
Introduction: Click chemistry has been exploited widely in the past to expedite lead discovery and optimization. Indeed, Copper-catalyzed azide-alkyne......
期刊： EXPERT OPINION ON DRUG DISCOVERY, 2020; 15 (2)
Introduction: The global incidence of hepatocellular carcinoma (HCC) is not expected to decline significantly over the next 30 years. And although the......
期刊： EXPERT OPINION ON DRUG DISCOVERY, 2019; 14 (4)
Introduction: Our understanding of the complexity of cardiovascular disease pathophysiology remains very incomplete and has hampered cardiovascular dr......
期刊： EXPERT OPINION ON DRUG DISCOVERY, 2018; 13 (1)
Introduction: The overexpression of matrix metalloproteinase (MMP) plays an important role in the context of tumor invasion and metastasis, and MMP-2 ......
期刊： EXPERT OPINION ON DRUG DISCOVERY, 2018; 13 (1)
Introduction: Molecular dynamics (MD) simulations can provide not only plentiful dynamical structural information on biomacromolecules but also a weal......
