期刊： JOURNAL OF MEDICINAL CHEMISTRY, 2021; 64 (6)
A series of conformationally constrained novel benzo[1,3]oxazinyloxazolidinones were designed, synthesized, and evaluated on their activities against ......
期刊： JOURNAL OF MEDICINAL CHEMISTRY, 2021; 64 (10)
To effectively treat gastric cancer, we innovatively attempted to develop a metal agent to integrate immunotherapy and chemotherapy by dual targeting ......
期刊： JOURNAL OF MEDICINAL CHEMISTRY, 2021; 64 (11)
Two series of novel o-(biphenyl-3-ylmethoxy)nitrophenyl compounds (A1-31 and B1-17) were designed as programmed cell death protein 1 (PD-1)/PD-ligand ......
期刊： JOURNAL OF MEDICINAL CHEMISTRY, 2021; 64 (13)
Eukaryotic elongation factor 2 kinase (eEF2K), a member of the atypical protein kinase family of alpha-kinases, is well-known as a negative regulator ......
期刊： JOURNAL OF MEDICINAL CHEMISTRY, 2021; 64 (14)
Selective Mcl-1 inhibitors may overcome the drug resistance caused by current anti-apoptotic Bcl-2 protein inhibitors in tumors with Mcl-1 overexpress......
期刊： JOURNAL OF MEDICINAL CHEMISTRY, 2021; 64 (14)
A series of novel heteroaromatic-difluoro-biphenyl-diarylpyrimidines were designed as non-nucleoside anti-HIV inhibitors targeting reverse transcripta......
期刊： JOURNAL OF MEDICINAL CHEMISTRY, 2021; 64 (15)
The emergence of multidrug-resistant bacteria has major issues for treating bacterial pneumonia. Currently, anoplin (GLLKRIKTLL-NH2) is a natural anti......
期刊： JOURNAL OF MEDICINAL CHEMISTRY, 2021; 64 (16)
We herein report the identification, structural optimization, and structure-activity relationship of thieno[2,3-d]pyrimidine derivatives as a novel ki......
期刊： JOURNAL OF MEDICINAL CHEMISTRY, 2021; 64 (9)
The alpha 7 nicotinic acetylcholine receptor (nAChR) is present in the central nervous system and plays an important role in cognitive function and me......
期刊： JOURNAL OF MEDICINAL CHEMISTRY, 2021; 64 (9)
Vitamin D-3 metabolites inhibit the expression of lipogenic genes by impairing sterol regulatory element-binding protein (SREBP), a master transcripti......
期刊： JOURNAL OF MEDICINAL CHEMISTRY, 2021; 64 (10)
Butyrylcholinesterase (BChE) has been considered as a potential therapeutic target for Alzheimer's disease (AD) because of its compensation capacity t......
期刊： JOURNAL OF MEDICINAL CHEMISTRY, 2021; 64 (14)
The neurotrophic receptor tyrosine kinase (NTRK) genes including NTRK1, NTRK2, and NTRK3 encode the tropomyosin receptor kinase (Trk) proteins TrkA, T......
期刊： JOURNAL OF MEDICINAL CHEMISTRY, 2021; 64 (15)
Targeted protein degradation is a promising area in the discovery and development of innovative therapeutics. Molecular glues mediate proximity-induce......
期刊： JOURNAL OF MEDICINAL CHEMISTRY, 2021; 64 (6)
Proteostasis is the process of regulating intracellular proteins to maintain the balance of the cell proteome, which is crucial for cancer cell surviv......
期刊： JOURNAL OF MEDICINAL CHEMISTRY, 2021; 64 (9)
N-Methyl-D-aspartate receptors (NMDARs) are glutamate-gated Na+ and Ca2+-permeable ion channels involved in excitatory synaptic transmission and synap......
