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Identifying nootropic drug targets via large-scale cognitive GWAS and transcriptomics

期刊: NEUROPSYCHOPHARMACOLOGY, 2021; 46 (10)

Broad-based cognitive deficits are an enduring and disabling symptom for many patients with severe mental illness, and these impairments are inadequat......

Aberrant triple-network connectivity patterns discriminate biotypes of first-episode medication-naive schizophrenia in two large independent cohorts

期刊: NEUROPSYCHOPHARMACOLOGY, ; ()

Schizophrenia is a complex disorder associated with aberrant brain functional connectivity. This study aims to demonstrate the relation of heterogeneo......

Autistic-like behavior, spontaneous seizures, and increased neuronal excitability in a Scn8a mouse model

期刊: NEUROPSYCHOPHARMACOLOGY, ; ()

Patients with SCN8A epileptic encephalopathy exhibit a range of clinical features, including multiple seizure types, movement disorders, and behaviora......

Long-term alcohol consumption alters dorsal striatal dopamine release and regulation by D2 dopamine receptors in rhesus macaques

期刊: NEUROPSYCHOPHARMACOLOGY, ; ()

The dorsal striatum (DS) is implicated in behavioral and neural processes including action control and reinforcement. Alcohol alters these processes i......

Neural correlates of anger expression in patients with PTSD

期刊: NEUROPSYCHOPHARMACOLOGY, ; ()

Anger is a common and debilitating symptom of post-traumatic stress disorder (PTSD). Although studies have identified brain circuits underlying anger ......

Changes in the brain structural connectome after a prospective randomized clinical trial of lithium and quetiapine treatment in youth with bipolar disorder

期刊: NEUROPSYCHOPHARMACOLOGY, ; ()

The goals of the current study were to determine whether topological organization of brain structural networks is altered in youth with bipolar disord......

Examination of the association between exposure to childhood maltreatment and brain structure in young adults: a machine learning analysis

期刊: NEUROPSYCHOPHARMACOLOGY, ; ()

Exposure to maltreatment during childhood is associated with structural changes throughout the brain. However, the structural differences that are mos......

Restoring glutamate homeostasis in the nucleus accumbens via endocannabinoid-mimetic drug prevents relapse to cocaine seeking behavior in rats

期刊: NEUROPSYCHOPHARMACOLOGY, 2021; 46 (5)

Impaired glutamate homeostasis is a key characteristic of the neurobiology of drug addiction in rodent models and contributes to the vulnerability to ......

Integration analysis of methylation quantitative trait loci and GWAS identify three schizophrenia risk variants

期刊: NEUROPSYCHOPHARMACOLOGY, 2020; 45 (7)

Genome-wide association studies (GWAS) have identified hundreds of genetic variants associated with schizophrenia (SCZ). However, prioritizing risk va......

Exosomes from patients with major depression cause depressive-like behaviors in mice with involvement of miR-139-5p-regulated neurogenesis

期刊: NEUROPSYCHOPHARMACOLOGY, 2020; 45 (6)

Exosomal microRNAs (miRNAs) have been suggested to participate in the pathogenesis of neuropsychiatric diseases, but their role in major depressive di......

Modafinil enhances cognitive, but not emotional conflict processing via enhanced inferior frontal gyrus activation and its communication with the dorsomedial prefrontal cortex

期刊: NEUROPSYCHOPHARMACOLOGY, 2020; 45 (6)

Cognitive control regulates cognitive and emotional systems to facilitate goal-directed behavior in the context of task-irrelevant distractors. Cognit......

A multipredictor model to predict the conversion of mild cognitive impairment to Alzheimer's disease by using a predictive nomogram

期刊: NEUROPSYCHOPHARMACOLOGY, 2020; 45 (2)

Predicting the probability of converting from mild cognitive impairment (MCI) to Alzheimer's disease (AD) is still a challenging task. This study aims......

Rislenemdaz treatment in the lateral habenula improves despair-like behavior in mice

期刊: NEUROPSYCHOPHARMACOLOGY, 2020; 45 (10)

The specific GluN2B antagonist rislenemdaz (Ris; a.k.a. MK-0657 and CERC-301) is in phase II clinical trial as an antidepressive drug, but the working......

Identification of a functional human-unique 351-bp Alu insertion polymorphism associated with major depressive disorder in the 1p31.1 GWAS risk loci

期刊: NEUROPSYCHOPHARMACOLOGY, 2020; 45 (7)

Genome-wide association studies (GWAS) have reported substantial single-nucleotide polymorphisms (SNPs) associated with major depressive disorder (MDD......

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