期刊： CANCER DISCOVERY, 2021; 11 (5)
For millions of years, endogenous retroelements have remained transcriptionally silent within mammalian genomes by epigenetic mechanisms. Modern antic......
期刊： CANCER DISCOVERY, 2021; 11 (2)
Accumulating evidence supports the impact of the gut microbiota on the clinical efficacy of cancer immunotherapies against extraintestinal tumors, but......
期刊： CANCER DISCOVERY, 2021; 11 (7)
Specific mechanisms by which tumor-infiltrating lymphocytes (TIL) become dysfunctional remain poorly understood. Here, we employed a two-pronged appro......
期刊： CANCER DISCOVERY, 2021; 11 (8)
A number of cancer drugs activate innate immune pathways in tumor cells but unfortunately also compromise antitumor immune function. We discovered tha......
期刊： CANCER DISCOVERY, 2021; 11 (5)
Mutations of subunits of the SWI/SNF chromatin remodeling complexes occur commonly in cancers of different lineages, including advanced thyroid cancer......
期刊： CANCER DISCOVERY, 2021; 11 (4)
The upcoming decade of precision medicine for cancer is moving from the translation of specific genetic findings into clinically relevant improvement ......
期刊： CANCER DISCOVERY, 2021; 11 (8)
Epigenetic regulators are a class of promising targets in combination with immune checkpoint inhibitors for cancer treatment, but the impact of the br......
期刊： CANCER DISCOVERY, 2021; 11 (7)
Mutations in IFN and MHC signaling genes endow immunotherapy resistance. Patients with colorectal cancer infrequently exhibit IFN and MHC signaling ge......
期刊： CANCER DISCOVERY, 2021; 11 (5)
Glioblastoma (GBM) contains self-renewing GBM stem cells (GSC) potentially amenable to immunologic targeting, but chimeric antigen receptor (CAR) T-ce......
期刊： CANCER DISCOVERY, 2021; 11 (6)
Immune checkpoint blockade (ICB) therapy revolutionized cancer treatment, but many patients with impaired MHC-I expression remain refractory. Here, we......
期刊： CANCER DISCOVERY, 2021; 11 (1)
Chromosome copy-number variations are a hallmark of cancer. Among them, the prevalent chromosome 17p deletions are associated with poor prognosis and ......
期刊： CANCER DISCOVERY, 2021; 11 (1)
On-target resistance to next-generation TRK inhibitors in TRK fusion-positive cancers is largely uncharacterized. In patients with these tumors, we fo......
期刊： CANCER DISCOVERY, 2021; 11 (2)
Due to the disseminated nature of leukemia, malignant cells are exposed to many different tissue microenvironments, including a variety of extramedull......
期刊： CANCER DISCOVERY, 2021; 11 (2)
Glioblastoma is a universally lethal cancer driven by glioblastoma stem cells (GSC). Here, we interrogated N-6-methyladenosine (m6A) mRNA modification......
期刊： CANCER DISCOVERY, 2021; 11 (2)
Recent clinical and preclinical advances have highlighted the existence of a previously hypothesized lymphogenous route of metastasis. However, due to......
