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Comprehensive analysis of PLKs expression and prognosis in breast cancer

期刊: CANCER GENETICS, 2022; 268 ()

Objective: A thorough examination of PLKs in breast cancer, including their expression and prognosis. Methods: With the help of the Oncomine database,......

JIF:2.25

Impact of a haplotype (composed of the APC, KRAS, and TP53 genes) on colorectal adenocarcinoma differentiation and patient prognosis

期刊: CANCER GENETICS, 2022; 268 ()

Background: Many types of gene mutation are associated with the drug resistance of cancer cells. XELOX is a new and efficient surgical adjuvant chemot......

JIF:2.25

Pan-cancer landscape of abnormal ctDNA methylation across human tumors

期刊: CANCER GENETICS, 2022; 268 ()

Background: The aim of this paper is to explore the correlation between circulating tumor DNA (ctDNA) methylation and mutations and its value in clini......

JIF:2.25

Mesothelin CAR-T cells secreting PD-L1 blocking scFv for pancreatic cancer treatment

期刊: CANCER GENETICS, 2022; 268-269 ()

PD-1/PD-L1 pathway caused immunosuppression accounts, at least partly, for the poor therapeutic effect of Chimeric Antigen Receptor T (CAR-T) on solid......

JIF:2.25

The role of P62 in the development of human thyroid cancer and its possible mechanism

期刊: CANCER GENETICS, 2021; 256 ()

Background: Thyroid cancer is the most common malignancy in human endocrine system. Increasing evidence has indicated that p62 plays a key role in tum......

A hereditary ovarian cancer family with rare pathogenic splicing mutation: Implications for variant interpretation

期刊: CANCER GENETICS, 2021; 256 ()

The BRCA1/2 gene is important for assessing the risk of familial/hereditary ovarian cancer (OC). This case is a patient with OC, and two of her immedi......

Gene expression-based immune infiltration analyses of liver cancer and their associations with survival outcomes

期刊: CANCER GENETICS, 2021; 254 ()

Introduction: Liver cancer is one of the most lethal malignancies, presenting inferior survival outcomes once diagnosed. Current therapeutic approache......

Association between XRCC3 Thr241Met polymorphism and risk of gynecological malignancies: A meta-analysis

期刊: CANCER GENETICS, 2021; 254 ()

Studies have investigated the relationship between the X-ray cross-complementing group 3 (XRCC3) Thr241Met polymorphism and the risk of gynecological ......

Novel MET exon 14 skipping analogs characterized in non-small cell lung cancer patients: A case study

期刊: CANCER GENETICS, 2021; 256 ()

MET exon 14 skipping (METex14) is a validated oncogenic driver in lung cancer and MET tyrosine kinase inhibitors are now available as effective clinic......

Whole-exome sequencing in osteosarcoma with distinct prognosis reveals disparate genetic heterogeneity

期刊: CANCER GENETICS, 2021; 256 ()

The genomic profiles of osteosarcoma (OS) patients have been extensively investigated; however, the genetic prognostic biomarkers still remain unclear......

TCGA dataset screening for genes implicated in endometrial cancer using RNA-seq profiling

期刊: CANCER GENETICS, 2021; 254 ()

The molecular basis of the mechanism and the potential biomarkers of endometrial cancer (EC) remain to be studied. In the present study, we hypothesiz......

Determination of the key ccRCC-related molecules from monolayer network to three-layer network

期刊: CANCER GENETICS, 2021; 256 ()

Clear cell renal cell carcinoma (ccRCC), with an increasing incidence rate, is one of the ubiquitous cancers. Its pathogenic factors are complicated a......

A 10-gene-methylation-based signature for prognosis prediction of colorectal cancer

期刊: CANCER GENETICS, 2021; 252 ()

Background: Colorectal cancer (CRC) is a common malignant tumor of digestive tract which has high incidence and mortality rates. Accurate prognosis pr......

Rare and favorable prognosis of pediatric acute lymphoblastic leukemia with TLS-ERG fusion gene: Case report with long-term follow-up and review of literature

期刊: CANCER GENETICS, 2021; 256 ()

In the study of acute myeloid leukemia (AML), TLS-ERG (also called FUS-ERG or TLS/FUS-ERG) was found to be closely associated with extramedullary dise......

Genetic heterogeneity and predictive biomarker for pulmonary sarcomatoid carcinomas

期刊: CANCER GENETICS, 2021; 250 ()

Purpose: The aim of this study is to investigate the genetic heterogeneity (carcinomatous vs. sarcomatous components) and predictive biomarkers in pat......

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