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Effect of mitophagy in oocytes and granulosa cells on oocyte quality

期刊: BIOLOGY OF REPRODUCTION, 2021; 104 (2)

Mitophagy is the process by which cells selectively remove supernumerary or damaged mitochondria through autophagy, and is crucial for mitochondria) h......

EZH2 is essential for spindle assembly regulation and chromosomal integrity during porcine oocyte meiotic maturation

期刊: BIOLOGY OF REPRODUCTION, 2021; 104 (3)

Enhancer of zeste homolog 2 (EZH2) has been extensively investigated to participate in diverse biological processes, including carcinogenesis, the cel......

L-amino acid oxidase 1 in sperm is associated with reproductive performance in male mice and bulls

期刊: BIOLOGY OF REPRODUCTION, 2021; 104 (5)

Sperm quality is an important indicator of male fertility, and a suitable biomarker enables the selection of high-quality spermatozoa. We previously f......

Par3/integrin beta 1 regulates embryo adhesion via changing endometrial luminal epithelium polarity

期刊: BIOLOGY OF REPRODUCTION, 2021; 104 (6)

The objective is to investigate the pathophysiological significance of Par3 and integrin beta 1 with regard to the functionality of the endometrial lu......

The effects of the phthalate DiNP on reproduction

期刊: BIOLOGY OF REPRODUCTION, 2021; 104 (2)

Di-isononyl phthalate (DiNP) is a high molecular weight, general purpose, plasticizer used primarily in the manufacture of polymers and consumer produ......

Melatonergic systems of AANAT, melatonin, and its receptor MT2 in the corpus luteum are essential for reproductive success in mammals

期刊: BIOLOGY OF REPRODUCTION, 2021; 104 (2)

Corpus luteum (CL) plays a critical role in mammalian reproductive physiology. Its dysfunction will lead to infertility or habitual abortion. In the c......

ZC3H4-a novel Cys-Cys-Cys-His-type zinc finger protein-is essential for early embryogenesis in mice

期刊: BIOLOGY OF REPRODUCTION, 2021; 104 (2)

Zinc finger domains of the Cys-Cys-Cys-His (CCCH) class are evolutionarily conserved proteins that bind nucleic acids and are involved in various biol......

Uterine decidual niche modulates the progressive dedifferentiation of spiral artery vascular smooth muscle cells during human pregnancy

期刊: BIOLOGY OF REPRODUCTION, 2021; 104 (3)

Uterine spiral artery (SPA) remodeling is a crucial event during pregnancy to provide enough blood supply to maternal-fetal interface and meet the dem......

Mutant Zp1 impedes incorporation of ZP3 and ZP4 in the zona pellucida, resulting in zona absence and female infertility in rats

期刊: BIOLOGY OF REPRODUCTION, 2021; 104 (6)

The zona pellucida (ZP) plays vital roles in reproductive processes including oogenesis, fertilization, and preimplantation development. Both human an......

Overview of extracellular vesicles in the pathogenesis of preeclampsia

期刊: BIOLOGY OF REPRODUCTION, 2021; 105 (1)

Preeclampsia (PE) is a leading cause of maternal and fetal-neonatal deaths, and its pathogenesis has been linked to the involvement of extracellular v......

NOTCH signaling pathway is required for bovine early embryonic development

期刊: BIOLOGY OF REPRODUCTION, 2021; 105 (2)

The NOTCH signaling pathway plays an important role in regulating various biological processes, including lineage specification and apoptosis. Multipl......

Multi-omics reveals a relationship between endometrial amino acid metabolism and autophagy in women with recurrent miscarriage

期刊: BIOLOGY OF REPRODUCTION, 2021; 105 (2)

Deterioration of the endometrial environment is an essential cause of recurrent miscarriage (RM). However, current studies in terms of endometrial ami......

Notch1 is crucial for decidualization and maintaining the first pregnancy in the mouse

期刊: BIOLOGY OF REPRODUCTION, 2021; 104 (3)

The endometrium undergoes a pregnancy-delivery-repair cycle multiple times during the reproductive lifespan in females. Decidualization is one of the ......

Mitochondrial transfer from induced pluripotent stem cells rescues developmental potential of in vitro fertilized embryos from aging females

期刊: BIOLOGY OF REPRODUCTION, 2021; 104 (5)

Conventional heterologous mitochondrial replacement therapy is clinically complicated by "tri-parental" ethical concerns and limited source of healthy......

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