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Immune-related adverse events predict responses to PD-1 blockade immunotherapy in hepatocellular carcinoma

期刊: INTERNATIONAL JOURNAL OF CANCER, 2021; 149 (4)

Immune checkpoint blockade has demonstrated remarkable efficacy in hepatocellular carcinoma (HCC) but is also commonly accompanied by immune-related a......

FOXD1 promotes dedifferentiation and targeted therapy resistance in melanoma by regulating the expression of connective tissue growth factor

期刊: INTERNATIONAL JOURNAL OF CANCER, 2021; 149 (3)

Metastatic melanoma is an aggressive skin cancer and associated with a poor prognosis. In clinical terms, targeted therapy is one of the most importan......

Caspase-8: A key protein of cross-talk signal way in "PANoptosis" in cancer

期刊: INTERNATIONAL JOURNAL OF CANCER, 2021; 149 (7)

Cysteinyl aspartate specific proteinase (Caspase)-8 has long been considered a promoter of apoptosis and part of the mechanism by which cytotoxic drug......

Application of a classifier combining bronchial transcriptomics and chest computed tomography features facilitates the diagnostic evaluation of lung cancer in smokers and nonsmokers

期刊: INTERNATIONAL JOURNAL OF CANCER, 2021; 149 (6)

Lung cancer screening by computed tomography (CT) reduces mortality but exhibited high false-positive rates. We established a diagnostic classifier co......

Cytotoxic T lymphocyte-associated protein 4 antibody aggrandizes antitumor immune response of oncolytic virus M1 via targeting regulatory T cells

期刊: INTERNATIONAL JOURNAL OF CANCER, 2021; 149 (6)

Oncolytic virotherapies are perceived as remarkable immunotherapies coming into view and represent highly promising cancer treatments, yet to figure o......

Surveillance of premalignant gastric cardia lesions: A population-based prospective cohort study in China

期刊: INTERNATIONAL JOURNAL OF CANCER, 2021; 149 (9)

In our study, we aimed to assess the long-term risk of gastric cardia adenocarcinoma (GCA) for patients with different histological cardia lesions to ......

Reinduction chemotherapy regimen involved decitabine and cladribine improves the prognosis of patients with relapsed or refractory acute myeloid leukemia: A preliminary study

期刊: INTERNATIONAL JOURNAL OF CANCER, 2021; 149 (4)

Relapsed/refractory acute myeloid leukemia (R/R-AML) is characterized by a high incidence, short survival and poor prognosis. Presently, no unified ef......

Genetic variations in nucleotide excision repair pathway genes and hepatoblastoma susceptibility

期刊: INTERNATIONAL JOURNAL OF CANCER, 2021; 149 (9)

The etiology of hepatoblastoma is largely unknown due to the rarity of this disease. Nucleotide excision repair (NER), a versatile system in repairing......

Associations of vitamin D status with colorectal cancer risk and survival

期刊: INTERNATIONAL JOURNAL OF CANCER, 2021; 149 (3)

Biological evidence suggests that vitamin D has numerous anticancer functions, but the associations between vitamin D status and colorectal cancer (CR......

Alterations in the oral and gut microbiome of colorectal cancer patients and association with host clinical factors

期刊: INTERNATIONAL JOURNAL OF CANCER, 2021; 149 (4)

Previous studies have suggested that gut microbiota plays a critical role in colorectal cancer (CRC). Although preliminary comparisons of the oral and......

Upfront transplantation may have better outcomes than pretransplant cytoreductive therapy for treating patients with MDS-EB-1 or MDS-EB-2

期刊: INTERNATIONAL JOURNAL OF CANCER, 2021; 149 (5)

Whether patients with myelodysplastic syndrome (MDS) undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) benefit from pretranspl......

Causal association of childhood obesity with cancer risk in adulthood: A Mendelian randomization study

期刊: INTERNATIONAL JOURNAL OF CANCER, 2021; 149 (7)

In observational studies of children and adolescents, higher body weight has been associated with distinct disease outcomes, including cancer, in adul......

Burden of pancreatic cancer along with attributable risk factors in Europe between 1990 and 2019, and projections until 2039

期刊: INTERNATIONAL JOURNAL OF CANCER, 2021; 149 (5)

Projecting the burden of pancreatic cancer over time provides essential information to effectively plan measures for its management and prevention. He......

Phase I clinical trial of HC-1119: A deuterated form of enzalutamide

期刊: INTERNATIONAL JOURNAL OF CANCER, 2021; 149 (7)

The purpose of our study was to investigate the safety, pharmacokinetics (PK), and initial antitumor efficacy of HC-1119 in patients with metastatic c......

Real-world utilization of EGFR TKIs and prognostic factors for survival in EGFR-mutated non-small cell lung cancer patients with brain metastases

期刊: INTERNATIONAL JOURNAL OF CANCER, 2021; 149 (5)

Brain metastases (BMs) cause morbidity and mortality in patients with non-small cell lung cancer (NSCLC). The optimal management of epidermal growth f......

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