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Using Quasispecies Patterns of Hepatitis B Virus to Predict Hepatocellular Carcinoma With Deep Sequencing and Machine Learning

期刊: JOURNAL OF INFECTIOUS DISEASES, 2021; 223 (11)

Background. Hepatitis B virus (HBV) infection is one of the main leading causes of hepatocellular carcinoma (HCC) worldwide. However, it remains uncer......

Correlation Between Early Plasma Interleukin 37 Responses With Low Inflammatory Cytokine Levels and Benign Clinical Outcomes in Severe Acute Respiratory Syndrome Coronavirus 2 Infection

期刊: JOURNAL OF INFECTIOUS DISEASES, 2021; 223 (4)

Background. The immune protective mechanisms during severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection remain to be deciphered for t......

Gonococcal Adaptation to Palmitic Acid Through farAB Expression and FadD Activity Mutations Increases In Vivo Fitness in a Murine Genital Tract Infection Model

期刊: JOURNAL OF INFECTIOUS DISEASES, 2021; 224 (1)

Neisseria gonorrhoeae is a bacterial pathogen that colonizes mucosal epithelia that are rich in antimicrobial molecules such as long-chain fatty acids......

Human Papillomavirus Prevalence and Integration Status in Tissue Samples of Bladder Cancer in the Chinese Population

期刊: JOURNAL OF INFECTIOUS DISEASES, 2021; 224 (1)

Background. Human papillomavirus (HPV) infection is associated with multiple types of cancer, but the evidence has not yet been fully elucidated in bl......

Clinical Features, Replication Competence, and Innate Immune Responses of Human Adenovirus Type 7 Infection

期刊: JOURNAL OF INFECTIOUS DISEASES, 2021; 223 (8)

Background. Epidemiologic reports suggest that the most severe or fatal adenoviral disease in children might be associated with human adenovirus (HAdV......

Signaling Lymphocytic Activation Molecule Family-7 Alleviates Corneal Inflammation by Promoting M2 Polarization

期刊: JOURNAL OF INFECTIOUS DISEASES, 2021; 223 (5)

Background. Signaling lymphocytic activation molecule family-7 (SLAMF7) functions as an immune checkpoint molecule on macrophages in antitumor immunit......

Influenza Vaccination and Hospitalization Outcomes Among Older Patients With Cardiovascular or Respiratory Diseases

期刊: JOURNAL OF INFECTIOUS DISEASES, 2021; 223 (7)

Background: Influenza vaccination has been suggested to protect against death and recurrent events among patients with cardiovascular disease or chron......

Introduction, Transmission Dynamics, and Fate of Early Severe Acute Respiratory Syndrome Coronavirus 2 Lineages in Santa Clara County, California

期刊: JOURNAL OF INFECTIOUS DISEASES, 2021; 224 (2)

We combined viral genome sequencing with contact tracing to investigate introduction and evolution of severe acute respiratory syndrome coronavirus 2 ......

Susceptibility and Attenuated Transmissibility of SARS-CoV-2 in Domestic Cats

期刊: JOURNAL OF INFECTIOUS DISEASES, 2021; 223 (8)

Domestic cats, an important companion animal, can be infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). This has aroused conc......

Whole-Proteome Differential Screening Identifies Novel Vaccine Candidates for Schistosomiasis japonica

期刊: JOURNAL OF INFECTIOUS DISEASES, 2021; 223 (7)

Schistosomiasis remains a leading cause of chronic morbidity in endemic regions despite decades of widespread mass chemotherapy with praziquantel. Usi......

Evidence of Severe Acute Respiratory Syndrome Coronavirus 2 Replication and Tropism in the Lungs, Airways, and Vascular Endothelium of Patients With Fatal Coronavirus Disease 2019: An Autopsy Case Series

期刊: JOURNAL OF INFECTIOUS DISEASES, 2021; 223 (5)

Background. The coronavirus disease 2019 (COVID-19) pandemic continues to produce substantial morbidity and mortality. To understand the reasons for t......

beta-D-N-4-hydroxycytidine Inhibits SARS-CoV-2 Through Lethal Mutagenesis But Is Also Mutagenic To Mammalian Cells

期刊: JOURNAL OF INFECTIOUS DISEASES, 2021; 224 (3)

Mutagenic ribonucleosides can act as broad-based antiviral agents. They are metabolized to the active ribonucleoside tri-phosphate form and concentrat......

Role of Base Excision Repair in Listeria monocytogenes DNA Stress Survival During Infections

期刊: JOURNAL OF INFECTIOUS DISEASES, 2021; 223 (4)

Background. Base excision repair (BER), consisting mostly of lesion-specific DNA glycosylases and apurinic/apyrimidinic (AP) endonucleases, is one of ......

Interferon-Induced Macrophage-Derived Exosomes Mediate Antiviral Activity Against Hepatitis B Virus Through miR-574-5p

期刊: JOURNAL OF INFECTIOUS DISEASES, 2021; 223 (4)

Background. Interferon alfa (IFN-alpha) has been proved effective in treating chronic hepatitis B (CHB), owing to its ability to suppress hepatitis B ......

Analysis of Treponema pallidum Strains From China Using Improved Methods for Whole-Genome Sequencing From Primary Syphilis Chancres

期刊: JOURNAL OF INFECTIOUS DISEASES, 2021; 223 (5)

Background. Whole-genome sequencing (WGS) of lreponema pallidum subspecies pallidum (TPA) has been constrained by the lack of in vitro cultivation met......

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