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TGF-beta 1 modulates temozolomide resistance in glioblastoma via altered microRNA processing and elevated MGMT

期刊: NEURO-ONCOLOGY, 2021; 23 (3)

Background. Our previous studies have indicated that miR-198 reduces cellular methylguanine DNA methyltransferase (MGMT) levels to enhance temozolomid......

PTRF/cavin-1 remodels phospholipid metabolism to promote tumor proliferation and suppress immune responses in glioblastoma by stabilizing cPLA2

期刊: NEURO-ONCOLOGY, 2021; 23 (3)

Background. Metabolism remodeling is a hallmark of glioblastoma (GBM) that regulates tumor proliferation and the immune microenvironment. Previous stu......

EIF4A3-induced circular RNA ASAP1 promotes tumorigenesis and temozolomide resistance of glioblastoma via NRAS/MEK1/ERK1-2 signaling

期刊: NEURO-ONCOLOGY, 2021; 23 (4)

Background. Acquired chemoresistance is a major challenge in the clinical treatment of glioblastoma (GBM). Circular RNAs have been verified to play a ......

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