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Avatrombopag for the treatment of thrombocytopenia post hematopoietic stem-cell transplantation

期刊: THERAPEUTIC ADVANCES IN HEMATOLOGY, 2022; 13 ()

Background: Thrombocytopenia post hematopoietic stem-cell transplantation (HCT) usually contributes to poor outcomes with no standardized treatment. E......

Cardiovascular-specific mortality among multiple myeloma patients: a population-based study

期刊: THERAPEUTIC ADVANCES IN HEMATOLOGY, 2022; 13 ()

Introduction: Multiple myeloma (MM) survival has greatly improved in recent decades. MM is usually diagnosed at a median age of 66-70 years. MM patien......

Iron overload status in patients with non-transfusion-dependent thalassemia in China

期刊: THERAPEUTIC ADVANCES IN HEMATOLOGY, 2022; 13 ()

Background: Iron overload is one of the main factors that increase morbidity and mortality in patients with non-transfusion dependent thalassemia (NTD......

Prednisone plus IVIg compared with prednisone or IVIg for immune thrombocytopenia in pregnancy: a national retrospective cohort study

期刊: THERAPEUTIC ADVANCES IN HEMATOLOGY, 2022; 13 ()

Background: The responses of intravenous immunoglobulin (IVIg) or corticosteroids as the initial treatment on pregnancy with ITP were unsatisfactory. ......

Safety and efficacy of pegcetacoplan in paroxysmal nocturnal hemoglobinuria

期刊: THERAPEUTIC ADVANCES IN HEMATOLOGY, 2022; 13 ()

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired, hematologic disease characterized by complement-mediated hemolysis, thrombosis, and var......

Efficacy and safety of mesenchymal stem cells treatment for multidrug-resistant graft-versus-host disease after haploidentical allogeneic hematopoietic stem cell transplantation

期刊: THERAPEUTIC ADVANCES IN HEMATOLOGY, 2022; 13 ()

Purpose: Graft-versus-host disease (GVHD) is an important complication after human leukocyte antigen (HLA) haploidentical donor (HID) hematopoietic st......

The impact of bortezomib-based induction in newly diagnosed multiple myeloma with chromosome 1q21 gain

期刊: THERAPEUTIC ADVANCES IN HEMATOLOGY, 2022; 13 ()

Introduction: Bortezomib has been reported to favourably impact the outcomes of t(4;14) and del(17p) in multiple myeloma (MM), but its impact on gain ......

MYD88(L265P) and CD79B double mutations type (MCD type) of diffuse large B-cell lymphoma: mechanism, clinical characteristics, and targeted therapy

期刊: THERAPEUTIC ADVANCES IN HEMATOLOGY, 2022; 13 ()

MYD88/CD79B-mutated (MCD) genotype is a genetic subgroup of diffuse large B-cell lymphoma (DLBCL) with the co-occurrence of MYD88(L265P) and CD79B mut......

Clinical features of DDX41 mutation-related diseases: a systematic review with individual patient data

期刊: THERAPEUTIC ADVANCES IN HEMATOLOGY, 2021; 12 ()

Background: DDX41 serves as a DNA sensor in innate immunity and mutated DDX41 is pathogenic, mainly for myeloid neoplasms. Methods: In this study, "DD......

Interferon-alpha may help prevent molecular relapse of chronic myeloid leukemia after the discontinuation of tyrosine kinase inhibitors

期刊: THERAPEUTIC ADVANCES IN HEMATOLOGY, 2021; 12 ()

Background: Currently, the goal of chronic myeloid leukemia (CML) treatment is normal survival and good quality of life without life-long treatment, n......

Relapsed/refractory multiple myeloma-transformed plasma-cell leukemia successfully treated with daratumumab followed by autologous stem cell transplantation

期刊: THERAPEUTIC ADVANCES IN HEMATOLOGY, 2021; 12 ()

Daratumumab is a humanized anti-CD38 IgG1 monoclonal antibody which could be used for multiple myeloma (MM). MM with plasma-cell leukemia (PCL) transf......

Clinicopathological characteristics and long-term prognosis of monoclonal immunoglobulin light chain associated Fanconi syndrome

期刊: THERAPEUTIC ADVANCES IN HEMATOLOGY, 2021; 12 ()

Background and aims: Monoclonal immunoglobulin light chain associated Fanconi syndrome (LC-FS) is a rare disease that involves proximal tubules. As mo......

Acute myeloid leukemia with CPSF6-RARG fusion resembling acute promyelocytic leukemia with extramedullary infiltration

期刊: THERAPEUTIC ADVANCES IN HEMATOLOGY, 2021; 12 ()

Some subtypes of acute myeloid leukemia (AML) share morphologic, immunophenotypic, and clinical features of acute promyelocytic leukemia (APL), but la......

Nucleophosmin1 (NPM1) abnormality in hematologic malignancies, and therapeutic targeting of mutant NPM1 in acute myeloid leukemia

期刊: THERAPEUTIC ADVANCES IN HEMATOLOGY, 2020; 11 ()

Nucleophosmin (NPM1) is an abundant nucleolar protein that is implicated in a variety of biological processes and in the pathogenesis of several human......

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