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Insulin resistance induced by long-term sleep deprivation in rhesus macaques can be attenuated by Bifidobacterium

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2022; 322 (2)

Long-term sleep deprivation (SD) is a bad lifestyle habit, especially among specific occupational practitioners, characterized by circadian rhythm mis......

JIF:3.995

Vitamin D supplementation induces CatG-mediated CD4(+) T cell inactivation and restores pancreatic beta-cell function in mice with type 1 diabetes

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2022; 322 (1)

Type 1 diabetes (T1D) is a chronic autoimmune disease accompanied by the immune-mediated destruction of pancreatic beta-cells. In this study, we aimed......

JIF:3.995

Resveratrol mediates the miR-149/HMGB1 axis and regulates the ferroptosis pathway to protect myocardium in endotoxemia mice

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2022; 323 (1)

Endotoxemia is a common complication often used to model the acute inflammatory response associated with endotoxemia. Resveratrol has been shown to ex......

JIF:3.995

An effective preselection criterion for MODY with an increasingly positive genetic testing rate by NGS: results from two cohorts of Chinese children

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2022; 323 (6)

The purpose of this study was to determine the frequency of maturity-onset diabetes of the young (MODY) in two selected cohorts of Chinese children wi......

JIF:3.995

Troxerutin attenuates insulin resistance via pancreatic IL-22/JAK1/STAT3 signaling activation in dihydrotestosterone-induced polycystic ovary syndrome rats

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2022; 323 (5)

Polycystic ovary syndrome (PCOS) is an extremely common endocrine-metabolic disorder and the main cause of infertility in pre-menopausal women, thus t......

JIF:3.995

Pantothenate protects against obesity via brown adipose tissue activation

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2022; 323 (1)

Brown adipose tissue (BAT) is the primary site of adaptive thermogenesis, which is involved in energy expenditure and has received much attention in t......

JIF:3.995

Obesity and chronic kidney disease

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2022; 324 (1)

The prevalence of obesity has increased dramatically during the past decades, which has been a major health problem. Since 1975, the number of people ......

JIF:3.995

Light intensity alters the effects of light-induced circadian disruption on glucose and lipid metabolism in mice

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2022; 322 (1)

Circadian disruption induced by rotating light cycles has been linked to metabolic disorders. However, how the interaction of light intensity and ligh......

JIF:3.995

Regenerating myofiber directs Tregs and Th17 responses in inflamed muscle through the intrinsic TGF-beta signaling-mediated IL-6 production

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2022; 323 (1)

Transforming growth factor-beta (TGF-beta) is considered to be an important immune regulatory cytokine. However, it remains unknown whether and how th......

JIF:3.995

Apigenin promotes osteogenic differentiation of mesenchymal stem cells and accelerates bone fracture healing via activating Wnt/I3-catenin signaling

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2021; 320 (4)

Apigenin (API), a natural plant flavone, is abundantly found in common fruits and vegetables. As a bioactive flavonoid, API exhibits several activitie......

High uric acid induces liver fat accumulation via ROS/JNK/AP-1 signaling

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2021; 320 (6)

Uric acid is the end metabolite derived from the oxidation of purine compounds. Overwhelming evidence shows the vital interrelationship between hyperu......

Estrogen-Wnt signaling cascade regulates expression of hepatic fibroblast growth factor 21

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2021; 321 (2)

We have generated the transgenic mouse line LTCFDN in which dominant negative TCF7L2 (TCF7L2DN) is specifically expressed in the liver during adulthoo......

Evaluation of glucagon-like peptide-1 receptor expression in nondiabetic and diabetic atherosclerotic mice using PET tracer Ga-68-NODAGA-exendin-4

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2021; 320 (5)

Activation of glucagon-like peptide-1 receptor (GLP-1R) signaling attenuates development of atherosclerosis and vascular inflam-mation. However, the e......

The long noncoding RNA TUNAR modulates Wnt signaling and regulates human beta-cell proliferation

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2021; 320 (4)

Many long noncoding RNAs (lncRNAs) are enriched in pancreatic islets and several lncRNAs are linked to type 2 diabetes (T2D). Although they have emerg......

Transthyretin contributes to insulin resistance and diminishes exercise-induced insulin sensitivity in obese mice by inhibiting AMPK activity in skeletal muscle

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2021; 320 (4)

Exercise improves obesity-induced insulin resistance and metabolic disorders via mechanisms that remain unclear. Here, we show that the levels of the ......

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