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Hydrogel-coate d nee dles prevent puncture site bleeding

期刊: ACTA BIOMATERIALIA, 2021; 128 ()

Incomplete hemostasis after vascular cannulation can cause a hematoma or pseudoaneurysm and remains a significant clinical problem. We developed a hyd......

Dual-responsive nanohybrid based on degradable silica-coated gold nanorods for triple-combination therapy for breast cancer

期刊: ACTA BIOMATERIALIA, 2021; 128 ()

Multi-modal combination therapy has attracted great attention, owing to the unsatisfactory therapeutic efficacy of conventional chemotherapy. Mesoporo......

Cationic self-assembled peptide-based molecular hydrogels for extended ocular drug delivery

期刊: ACTA BIOMATERIALIA, 2021; 131 ()

The physiological barriers and clearance mechanism of the eye challenge the therapeutic delivery for treating various ocular disorders effectively. He......

Nanomedicines for the treatment of glaucoma: Current status and future perspectives

期刊: ACTA BIOMATERIALIA, 2021; 125 ()

Glaucoma is the global leading cause of irreversible blindness. It is a chronic progressive disorder and, therefore, often requires long-term manageme......

Dynamic precise dual-drug-backboned nano-prodrugs for selective chemotherapy

期刊: ACTA BIOMATERIALIA, 2021; 129 ()

To achieve an ideal drug delivery platform with precise composition and high tumor selectivity, the PEGylated dual-drug backboned prodrug was synthesi......

Role of Na+, K+-ATPase ion pump in osteoinduction

期刊: ACTA BIOMATERIALIA, 2021; 129 ()

Porous biphasic calcium phosphate bioceramic (BCP) possesses osteoinductivity to induce the osteoblastic commitment of mesenchymal stem cells (MSCs) a......

Fabrication of customized Ti6AI4V heterogeneous scaffolds with selective laser melting: Optimization of the architecture for orthopedic implant applications

期刊: ACTA BIOMATERIALIA, 2021; 126 ()

Orthopedic implants with heterogeneous porous structures were known as ideal bone osteointegration. This research introduced the selective laser melti......

Photo-responsive prodrug nanoparticles for efficient cytoplasmic delivery and synergistic photodynamic-chemotherapy of metastatic triple-negative breast cancer

期刊: ACTA BIOMATERIALIA, 2021; 126 ()

Triple-negative breast cancer (TNBC) have been considered as the most malignant subtype of breast cancer with leading incidence and mortality among fe......

Contact lenses coated with hybrid multifunctional ternary nanocoatings (Phytomolecule-coated ZnO nanoparticles:Gallic Acid:Tobramycin) for the treatment of bacterial and fungal keratitis

期刊: ACTA BIOMATERIALIA, 2021; 128 ()

Contact lenses are widely used for visual corrections. However, while wearing contact lenses, eyes typically face discomforts (itching, irritation, bu......

A 3D-printed PRP-GelMA hydrogel promotes osteochondral regeneration through M2 macrophage polarization in a rabbit model

期刊: ACTA BIOMATERIALIA, 2021; 128 ()

Osteochondral regeneration is an orchestrated process of inflammatory immunity, host cell response, and implant degradation in tissue engineering. Her......

A review of the physiological impact of rare earth elements and their uses in biomedical Mg alloys

期刊: ACTA BIOMATERIALIA, 2021; 130 ()

Magnesium (Mg) is well-tolerated by the body, displaying exceedingly low toxicity, rapid excretion, and numerous bioactive effects, including improved......

Biomaterials strategies to balance inflammation and tenogenesis for tendon repair

期刊: ACTA BIOMATERIALIA, 2021; 130 ()

Adult tendon tissue demonstrates a limited regenerative capacity, and the natural repair process leaves fibrotic scar tissue with inferior mechanical ......

The dependence of radio-sensitization efficiency on mitochondrial targeting with NaGdF4:Yb,Er nanoparticles

期刊: ACTA BIOMATERIALIA, 2021; 131 ()

Radio-sensitization is highly desired to reduce side-effect of the harsh dose of radiation therapy (RT), for which nanoparticles with high atomic numb......

Efficient delivery of cytosolic proteins by protein-hexahistidine-metal co-assemblies

期刊: ACTA BIOMATERIALIA, 2021; 129 ()

Proteins play key roles in most biological processes, and protein dysfunction can cause various diseases. Over the past few decades, tremendous develo......

Magnetic mesoporous embolic microspheres in transcatheter arterial chemoembolization for liver cancer

期刊: ACTA BIOMATERIALIA, 2021; 130 ()

Transcatheter arterial chemoembolization (TACE) is the main treatment for liver cancer. Although many embolic agents have been exploited in TACE, embo......

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