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Exosome-Mediated Transfer of circ_0000338 Enhances 5-Fluorouracil Resistance in Colorectal Cancer through Regulating MicroRNA 217 (miR-217) and miR-485-3p

期刊: MOLECULAR AND CELLULAR BIOLOGY, 2021; 41 (5)

Exosomes are microvesicles secreted by body cells for intercellular communication. The circular RNA circ_0000338 was found to be present in extracellu......

Overexpression of MicroRNA 142-5p Suppresses the Progression of Cervical Cancer through Targeting Phosphoinositol-3-Kinase Adaptor Protein 1 Expression

期刊: MOLECULAR AND CELLULAR BIOLOGY, 2021; 41 (6)

The aim of current study was to explore the mechanism of microRNA 142-5p (miR-142- 5p) in cervical cancer through mediating the phosphoinositol-3kinas......

Silencing of hsa_circ_0009035 Suppresses Cervical Cancer Progression and Enhances Radiosensitivity through MicroRNA 889-3p-Dependent Regulation of HOXB7

期刊: MOLECULAR AND CELLULAR BIOLOGY, 2021; 41 (6)

Circular RNAs (circRNAs), a novel type of endogenous noncoding RNAs, have been identified as critical regulators in human carcinogenesis. Here, we inv......

Elevated MicroRNA 183 Impairs Trophoblast Migration and Invasiveness by Downregulating FOXP1 Expression and Elevating GNG7 Expression during Preeclampsia

期刊: MOLECULAR AND CELLULAR BIOLOGY, 2021; 41 (1)

Preeclampsia (PE) is a hypertensive disorder of uncertain etiology that is the leading cause of maternal and fetal morbidity or mortality. The dysregu......

Sirtuin 5 Is Regulated by the SCFCyclin (F) Ubiquitin Ligase and Is Involved in Cell Cycle Control

期刊: MOLECULAR AND CELLULAR BIOLOGY, 2021; 41 (2)

The ubiquitin-proteasome system is essential for cell cycle progression. Cyclin F is a cell cycle-regulated substrate adapter F-box protein for the Sk......

Circular RNA 100146 Promotes Colorectal Cancer Progression by the MicroRNA 149/HMGA2 Axis

期刊: MOLECULAR AND CELLULAR BIOLOGY, 2021; 41 (2)

Colorectal cancer (CRC) has developed into the third leading cause of cancer-associated death worldwide. Studies have confirmed that circular RNAs (ci......

TRAF2 Ser-11 Phosphorylation Promotes Cytosolic Translocation of the CD40 Complex To Regulate Downstream Signaling Pathways

期刊: MOLECULAR AND CELLULAR BIOLOGY, 2020; 40 (9)

CD40 plays an important role in immune responses by activating the c-Jun N-terminal protein kinase (JNK) and NF-kappa B pathways; however, the precise......

Fbxo45 Binds SPRY Motifs in the Extracellular Domain of N-Cadherin and Regulates Neuron Migration during Brain Development

期刊: MOLECULAR AND CELLULAR BIOLOGY, 2020; 40 (14)

Several events during the normal development of the mammalian neo- cortex depend on N-cadherin, including the radial migration of immature projection ......

DHX33 Recruits Gadd45a To Cause DNA Demethylation and Regulates a Subset of Gene Transcription

期刊: MOLECULAR AND CELLULAR BIOLOGY, 2020; 40 (13)

RNA helicase DHX33 was found to regulate the transcription of multiple genes involved in cancer development. But the underlying molecular mechanism re......

Circular RNA CDR1as Exerts Oncogenic Properties Partially through Regulating MicroRNA 641 in Cholangiocarcinoma

期刊: MOLECULAR AND CELLULAR BIOLOGY, 2020; 40 (15)

It has been found that the circular RNA (circRNA) CDR1as is upregulated in cholangiocarcinoma (CCA) tissues. In this study, we tried to explore the ro......

WD Repeat Domain 77 Protein Regulates Translation of E2F1 and E2F3 mRNA

期刊: MOLECULAR AND CELLULAR BIOLOGY, 2020; 40 (24)

WD repeat domain 77 protein (WDR77) is required for cellular proliferation of lung and prostate epithelial cells during earlier stages of development ......

MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPI3 and C/EBPS

期刊: MOLECULAR AND CELLULAR BIOLOGY, 2020; 40 (17)

Transcription factors C/EBP beta and C/EBP beta are induced within hours after ini-tiation of adipogenesis in culture. They directly promote the expre......

Long Noncoding RNA H19 Promotes Tumorigenesis of Multiple Myeloma by Activating BRD4 Signaling by Targeting MicroRNA 152-3p

期刊: MOLECULAR AND CELLULAR BIOLOGY, 2020; 40 (3)

Multiple myeloma (MM) accounts for over twenty percent of hematological cancer-related death worldwide. Long noncoding RNA (lncRNA) H19 is associated ......

Regulation of Molecular Chaperone GRP78 by Hepatitis B Virus: Control of Viral Replication and Cell Survival

期刊: MOLECULAR AND CELLULAR BIOLOGY, 2020; 40 (3)

Chronic hepatitis B (CHB) remains a global health problem, carrying a high risk for progression into cirrhosis and liver failure. Molecular chaperones......

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