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Assessing serum IgG4 glycosylation profiles of IgG4-related disease using lectin microarray

期刊: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2021; 39 (2)

Objective IgG4 related disease (IgG4-RD) is a multiorgan fibroinflammatory disorder. Lectin microarray is a high-throughput glycosylation analysis tec......

Systematic analysis of the molecular mechanisms of methotrexate therapy for rheumatoid arthritis using text mining

期刊: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2021; 39 (4)

Objective The purpose of this study was to determine the expression of related genes in patients with rheumatoid arthritis (RA) treated with methotrex......

A multi-predictor model to predict risk of scleroderma renal crisis in systemic sclerosis: a multicentre, retrospective, cohort study

期刊: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2021; 39 (4)

Objective. Scleroderma renal crisis (SRC) is a life-threatening syndrome. The early identification of patients at risk is essential for timely treatme......

Insulin-like growth factor binding protein 7 as a candidate biomarker for systemic sclerosis

期刊: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2021; 39 (4)

Objectives. Systemic sclerosis (SSc) is an autoimmune disease clinically characterised by skin and internal organs fibrosis with high mortality. Howev......

Curcumin alleviates inflammation in Takayasu's arteritis by blocking CCL2 over-expression in adventitial fibroblasts

期刊: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2021; 39 (2)

Objective. Takayasu's arteritis (TAK) is a chronic inflammatory disease with several challenges in treatment. Curcumin is known for its anti-inflammat......

TIM-3 regulates the NETs-mediated dendritic cell activation in myeloperoxidase-ANCA-associated vasculitis

期刊: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2021; 39 (2)

Objective. T cell immunoglobulin and mucin domain 3 (TIM-3) has been reported as an important regulatory molecule on T cells and plays a pivotal role ......

Circulating T-FH cells is correlated with disease activity in anti-MDA5 antibody positive idiopathic inflammatory myopathies

期刊: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2021; 39 (4)

Objective Idiopathic inflammatory myopathies (IIM) are a group of disorders characterised by the production of autoantibodies and inflammatory infiltr......

Exercise pathophysiology differs between connective tissue diseases-associated pulmonary arterial hypertension and idiopathic pulmonary arterial hypertension

期刊: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2021; 39 (5)

Objective Previous studies demonstrated that connective tissue diseases-associated pulmonary arterial hypertension (CTD-PAH) had a worse prognosis tha......

Evaluating renal outcome of ANCA-associated renal vasculitis: comparative study of two histopathological scoring systems

期刊: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2021; 39 (2)

Objective. Renal risk score (RRS) and chronicity score (CS) are both newly proposed tools to predict end stage renal disease (ESRD) which could be app......

Interleukin-33 promotes proliferation and inhibits apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis

期刊: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2021; 39 (4)

Objective The aim of our study was to determine the effect of interleukin (IL)-33 on the proliferation, apoptosis, and secretion of inflammatory cytok......

Low-dose IL-2 effectively restored decreased regulatory T cells in patients with Behcet's disease

期刊: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2021; 39 (4)

Objective Although Behvet's disease (BD) is associated with immune mechanisms, the changes in circulating lymphocytes, especially regulatory T (Treg) ......

Interleukin 17E associates with haematologic involvement and autoantibody production in primary Sjogren's syndrome

期刊: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2021; 39 (2)

Objective Primary Sjogren's syndrome (pSS) is one of the most prevalent systemic autoimmune diseases characterised by inflammation and tissue damage o......

Antibody to peptidoglycan recognition protein (PGLYRP)-2 as a novel biomarker in rheumatoid arthritis

期刊: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2021; 39 (5)

Objective To identify novel autoantigens from circulating immune complexes (CICs) in rheumatoid arthritis (RA) patients and further explore their clin......

The association of different serum IgG4 levels with distinct clinical characteristics and treatment efficacy in patients with IgG4-related disease

期刊: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2021; 39 (4)

Objective To explore the clinical characteristics and treatment efficacy of IgG4-related disease (IgG4-RD) patients with different levels of serum IgG......

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