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Cannabinoid type 1 receptor inverse agonism attenuates dyslipidemia and atherosclerosis in APOE*3-Leiden.CETP mice

期刊: JOURNAL OF LIPID RESEARCH, 2021; 62 ()

Pharmacological blockade of the cannabinoid type 1 receptor, a G protein-coupled receptor expressed in the central nervous system and various peripher......

Atherosclerosis-associated hepatic secretion of VLDL but not PCSK9 is dependent on cargo receptor protein Surf4

期刊: JOURNAL OF LIPID RESEARCH, 2021; 62 ()

Plasma LDL is produced from catabolism of VLDL and cleared from circulation mainly via the hepatic LDL receptor (LDLR). Proprotein convertase subtilis......

Lipid signature of advanced human carotid atherosclerosis assessed by mass spectrometry imaging

期刊: JOURNAL OF LIPID RESEARCH, 2021; 62 ()

Carotid atherosclerosis is a risk factor for ischemic stroke, one of the main causes of mortality and disability worldwide. The disease is characteriz......

Evaluation of the available cholesterol concentration in the inner leaflet of the plasma membrane of mammalian cells

期刊: JOURNAL OF LIPID RESEARCH, 2021; 62 ()

Cholesterol is an essential component of the mammalian plasma membrane involved in diverse cellular processes. Our recent quantitative imaging analysi......

Hepatic deletion of Mboat7 (LPIAT1) causes activation of SREBP-1c and fatty liver

期刊: JOURNAL OF LIPID RESEARCH, 2021; 62 ()

Genetic variants that increase the risk of fatty liver disease and cirrhosis have recently been identified in the proximity of membrane-bound O-acyltr......

PEGylated AdipoRon derivatives improve glucose and lipid metabolism under insulinopenic and high-fat diet conditions

期刊: JOURNAL OF LIPID RESEARCH, 2021; 62 ()

The pleiotropic actions of adiponectin in improving cell survival and metabolism have motivated the development of small-molecule therapeutic agents f......

Endothelial ether lipids link the vasculature to blood pressure, behavior, and neurodegeneration

期刊: JOURNAL OF LIPID RESEARCH, 2021; 62 ()

Vascular disease contributes to neurodegeneration, which is associated with decreased blood pressure in older humans. Plasmalogens, ether phospholipid......

25-Hydroxycholesterol 3-sulfate is an endogenous ligand of DNA methyltransferases in hepatocytes

期刊: JOURNAL OF LIPID RESEARCH, 2021; 62 ()

The oxysterol sulfate, 25-hydroxy cholesterol 3-sulfate (25HC3S), has been shown to play an important role in lipid metabolism, inflammatory response,......

Simvastatin inhibits POVPC-mediated induction of endothelial-to-mesenchymal cell transition

期刊: JOURNAL OF LIPID RESEARCH, 2021; 62 ()

Endothelial-to-mesenchymal transition (EndMT), the process by which an endothelial cell (EC) undergoes a series of molecular events that result in a m......

Structure of mouse cytosolic sulfotransferase SULT2A8 provides insight into sulfonation of 7 alpha-hydroxyl bile acids

期刊: JOURNAL OF LIPID RESEARCH, 2021; 62 ()

Cytosolic sulfotransferases (SULTs) catalyze the transfer of a sulfonate group from the cofactor 3'-phosphoadenosine 5'-phosphosulfate to a hydroxyl (......

Slc43a3 is a regulator of free fatty acid flux(1)

期刊: JOURNAL OF LIPID RESEARCH, 2020; 61 (5)

Adipocytes take up long chain FAs through diffusion and protein-mediated transport, whereas FA efflux is considered to occur by diffusion. To identify......

Human GDPD3 overexpression promotes liver steatosis by increasing lysophosphatidic acid production and fatty acid uptake

期刊: JOURNAL OF LIPID RESEARCH, 2020; 61 (7)

The glycerol phosphate pathway produces more than 90% of the liver triacylglycerol (TAG). LysoPA, an intermediate in this pathway, is produced by glyc......

The lncRNA Gm15622 stimulates SREBP-1c expression and hepatic lipid accumulation by sponging the miR-742-3p in mice[S]

期刊: JOURNAL OF LIPID RESEARCH, 2020; 61 (7)

Excessive lipid deposition is a hallmark of NAFLD. Although much has been learned about the enzymes and metabolites involved in NAFLD, few studies hav......

Parenteral lipids shape gut bile acid pools and microbiota profiles in the prevention of cholestasis in preterm pigs[S]

期刊: JOURNAL OF LIPID RESEARCH, 2020; 61 (7)

Multi-component lipid emulsions, rather than soy-oil emulsions, prevent cholestasis by an unknown mechanism. Here, we quantified liver function, bile ......

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