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Phenotypic diversity and metabolic specialization of renal endothelial cells

期刊: NATURE REVIEWS NEPHROLOGY, ; ()

The adult kidney vasculature comprises diverse populations of endothelial cells that support specific functions according to their microenvironment. T......

COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup

期刊: NATURE REVIEWS NEPHROLOGY, 2020; 16 (12)

Kidney involvement in patients with coronavirus disease 2019 (COVID-19) is common, and can range from the presence of proteinuria and haematuria to ac......

Innate immunity in diabetic kidney disease

期刊: NATURE REVIEWS NEPHROLOGY, 2020; 16 (4)

Increasing evidence suggests that renal inflammation contributes to the pathogenesis and progression of diabetic kidney disease (DKD) and that anti-in......

Strategies to prevent kidney disease and its progression

期刊: NATURE REVIEWS NEPHROLOGY, 2020; 16 (3)

The 2020 World Kidney Day campaign highlights the importance of prevention of chronic kidney disease. Various strategies and therapies are available t......

Kidney dendritic cells: fundamental biology and functional roles in health and disease

期刊: NATURE REVIEWS NEPHROLOGY, 2020; 16 (7)

In this Review, the authors discuss general dendritic cell biology, including their development, trafficking and functional differentiation. The uniqu......

Autophagy in kidney homeostasis and disease

期刊: NATURE REVIEWS NEPHROLOGY, 2020; 16 (9)

In this Review, the authors summarize the basics of autophagy and the signalling pathways involved in its regulation, and examine the multiple roles o......

Macrophages: versatile players in renal inflammation and fibrosis

期刊: NATURE REVIEWS NEPHROLOGY, 2019; 15 (3)

Macrophages have important roles in immune surveillance and in the maintenance of kidney homeostasis; their response to renal injury varies enormously......

JIF:19.68

Epigenetic regulation in AKI and kidney repair: mechanisms and therapeutic implications

期刊: NATURE REVIEWS NEPHROLOGY, 2019; 15 (4)

Acute kidney injury (AKI) is a major public health concern associated with high morbidity and mortality. Despite decades of research, the pathogenesis......

JIF:19.68

Environmental pollution and kidney diseases

期刊: NATURE REVIEWS NEPHROLOGY, 2018; 14 (5)

The burden of disease and death attributable to environmental pollution is becoming a public health challenge worldwide, especially in developing coun......

JIF:19.68

Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases

期刊: NATURE REVIEWS NEPHROLOGY, 2018; 14 (8)

Mesenchymal stem cells (MSCs; also referred to as mesenchymal stromal cells) have attracted much attention for their ability to regulate inflammatory ......

JIF:19.68

Changes in the worldwide epidemiology of peritoneal dialysis

期刊: NATURE REVIEWS NEPHROLOGY, 2017; 13 (2)

As the global burden of chronic kidney disease continues to increase, so does the need for a cost-effective renal replacement therapy. In many countri......

JIF:14.1

Metabolomics for clinical use and research in chronic kidney disease

期刊: NATURE REVIEWS NEPHROLOGY, 2017; 13 (5)

Chronic kidney disease (CKD) has a high prevalence in the general population and is associated with high mortality; a need therefore exists for better......

JIF:14.1

Complement in ANCA-associated vasculitis: mechanisms and implications for management

期刊: NATURE REVIEWS NEPHROLOGY, 2017; 13 (6)

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of potentially life-threatening autoimmune diseases. The main histo......

JIF:14.1

CD36 in chronic kidney disease: novel insights and therapeutic opportunities

期刊: NATURE REVIEWS NEPHROLOGY, 2017; 13 (12)

CD36 (also known as scavenger receptor B2) is a multifunctional receptor that mediates the binding and cellular uptake of long-chain fatty acids, oxid......

JIF:14.1

Renoprotective effects of GLP1R agonists and SGLT2 inhibitors

期刊: NATURE REVIEWS NEPHROLOGY, 2017; 13 (12)

New data from the LEADER trial show that the glucagon-like peptide 1 receptor agonist liraglutide protects against diabetic nephropathy in patients wi......

JIF:14.1

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