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An overview of genetic mutations and epigenetic signatures in the course of pancreatic cancer progression

期刊: CANCER AND METASTASIS REVIEWS, 2021; 40 (1)

Pancreatic cancer (PC) is assumed to be an intimidating and deadly malignancy due to being the leading cause of cancer-led mortality, predominantly af......

Epigenetic modulation of immunotherapy and implications in head and neck cancer

期刊: CANCER AND METASTASIS REVIEWS, 2021; 40 (1)

Cancer progression is facilitated by distinct mechanisms developed by cancer cells to avoid immune recognition and clearance. The clinical application......

Neurocognitive impairment in Asian childhood cancer survivors: a systematic review

期刊: CANCER AND METASTASIS REVIEWS, 2020; 39 (1)

Childhood cancer survivors are at higher risk of developing neurocognitive deficits due to the intensive treatment they received at an early age. Most......

Long non-coding RNA: A recently accentuated molecule in chemoresistance in cancer

期刊: CANCER AND METASTASIS REVIEWS, 2020; 39 (3)

Chemotherapy is one of the important and effective options for cancer treatment in the past decades. Although the response rate of initial chemotherap......

Rho GTPases in cancer radiotherapy and metastasis

期刊: CANCER AND METASTASIS REVIEWS, 2020; 39 (4)

Despite treatment advances, radioresistance and metastasis markedly impair the benefits of radiotherapy to patients with malignancies. Functioning as ......

piRNAs: biogenesis and their potential roles in cancer

期刊: CANCER AND METASTASIS REVIEWS, 2020; 39 (2)

With the length of about 26-31 nt, PIWI-interacting RNA (piRNA) is a small non-coding RNA (ncRNA) that interacts with PIWI proteins to form the piRNA ......

Expression and function of epithelial cell adhesion molecule EpCAM: where are we after 40 years?

期刊: CANCER AND METASTASIS REVIEWS, 2020; 39 (3)

EpCAM (epithelial cell adhesion molecule) was discovered four decades ago as a tumor antigen on colorectal carcinomas. Owing to its frequent and high ......

Exosomes, metastases, and the miracle of cancer stem cell markers

期刊: CANCER AND METASTASIS REVIEWS, 2019; 38 (1-2)

Cancer-initiating cells (CIC) are the driving force in tumor progression. There is strong evidence that CIC fulfill this task via exosomes (TEX), whic......

JIF:6.67

New attempts for central nervous infiltration of pediatric acute lymphoblastic leukemia

期刊: CANCER AND METASTASIS REVIEWS, 2019; 38 (4)

The cure rate of acute lymphoblastic leukemia (ALL), the commonest childhood cancer, has been sharply improved and reached almost 90% ever since the c......

JIF:6.67

Correction to: mTOR co-targeting strategies for head and neck cancer therapy (vol 36, pg 491, 2017)

期刊: CANCER AND METASTASIS REVIEWS, 2019; 38 (1-2)

The author's name was tagged incorrectly in XML. Silvio Gutkind J should be tagged as J. Silvio Gutkind. Given name is J. Silvio and the Family name i......

JIF:6.67

Acidosis promotes tumorigenesis by activating AKT/NF-kappa B signaling

期刊: CANCER AND METASTASIS REVIEWS, 2019; 38 (1-2)

The microenvironment of solid tumors is often acidic due to poor vascular perfusion, regional hypoxia, and increased glycolytic activity of tumor cell......

JIF:6.67

Mutations of key driver genes in colorectal cancer progression and metastasis

期刊: CANCER AND METASTASIS REVIEWS, 2018; 37 (1)

The association between mutations of key driver genes and colorectal cancer (CRC) metastasis has been investigated by many studies. However, the resul......

JIF:6.67

Long non-coding RNAs in metastasis

期刊: CANCER AND METASTASIS REVIEWS, 2018; 37 (1)

Long non-coding RNA (lncRNA) genes have recently been discovered as key regulators of developmental, physiological, and pathological processes in huma......

JIF:6.67

Developing TRAIL/TRAIL death receptor-based cancer therapies

期刊: CANCER AND METASTASIS REVIEWS, 2018; 37 (4)

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that can initiate the apoptosis pathway by bi......

JIF:6.67

The roles of the COX2/PGE2/EP axis in therapeutic resistance

期刊: CANCER AND METASTASIS REVIEWS, 2018; 37 (2-3)

Therapeutic resistance has been and remains to be the major challenge in developing successful treatments for different cancers and therefore, underst......

JIF:6.67

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