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A novel lncRNA ARST represses glioma progression by inhibiting ALDOA-mediated actin cytoskeleton integrity

期刊: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2021; 40 (1)

Background Glioma is one of the most aggressive malignant brain tumors that is characterized with inevitably infiltrative growth and poor prognosis. A......

Circ-GALNT16 restrains colorectal cancer progression by enhancing the SUMOylation of hnRNPK

期刊: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2021; 40 (1)

Background Recent studies have investigated the role of circular RNAs (circRNAs) as significant regulatory factors in multiple cancer progression. Nev......

Hypoxia-dependent expression of MAP17 coordinates the Warburg effect to tumor growth in hepatocellular carcinoma

期刊: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2021; 40 (1)

Background Reprogrammed glucose metabolism, also known as the Warburg effect, which is essential for tumor progression, is regarded as a hallmark of c......

A positive feedback loop between Periostin and TGF beta 1 induces and maintains the stemness of hepatocellular carcinoma cells via AP-2 alpha activation

期刊: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2021; 40 (1)

Background: Liver cancer stem cells (LCSCs) play key roles in the metastasis, recurrence, and chemotherapeutic resistance of hepatocellular carcinoma ......

The SRSF1/circATP5B/miR-185-5p/HOXB5 feedback loop regulates the proliferation of glioma stem cells via the IL6-mediated JAK2/STAT3 signaling pathway

期刊: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2021; 40 (1)

Background Glioma is the most common and malignant tumor of central nervous system. The tumor initiation, self-renewal, and multi-lineage differentiat......

ZBTB28 induces autophagy by regulation of FIP200 and Bcl-XL facilitating cervical cancer cell apoptosis

期刊: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2021; 40 (1)

Background Among the common preventable cancers of women, cervical cancer has the highest morbidity. It is curable if detected at an early stage. Howe......

Targeting SERT promotes tryptophan metabolism: mechanisms and implications in colon cancer treatment

期刊: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2021; 40 (1)

Background Serotonin signaling has been associated with tumorigenesis and tumor progression. Targeting the serotonin transporter to block serotonin ce......

SLC6A8-mediated intracellular creatine accumulation enhances hypoxic breast cancer cell survival via ameliorating oxidative stress

期刊: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2021; 40 (1)

Background Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, with poor prognosis and limited treatment options. Hy......

Advances in drug development for hepatocellular carcinoma: clinical trials and potential therapeutic targets

期刊: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2021; 40 (1)

Although hepatocellular carcinoma (HCC) is one of the deadliest health burdens worldwide, few drugs are available for its clinical treatment. However,......

XPO1/CRM1 is a promising prognostic indicator for neuroblastoma and represented a therapeutic target by selective inhibitor verdinexor

期刊: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2021; 40 (1)

Background High-risk neuroblastoma patients have a 5-year survival rate of less than 50%. It's an urgent need to identify new therapeutic targets and ......

The CD112R/CD112 axis: a breakthrough in cancer immunotherapy

期刊: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2021; 40 (1)

The recent discovery of immune checkpoint inhibitors is a significant milestone in cancer immunotherapy research. However, some patients with primary ......

MYLK4 promotes tumor progression through the activation of epidermal growth factor receptor signaling in osteosarcoma

期刊: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2021; 40 (1)

Background Osteosarcoma (OS) is the most common primary bone cancer in adolescents and lung metastasis is the leading cause of death in patients with ......

Cellular based immunotherapy for primary liver cancer

期刊: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2021; 40 (1)

Primary liver cancer (PLC) is a common malignancy with high morbidity and mortality. Poor prognosis and easy recurrence on PLC patients calls for opti......

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