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Activation of microglial GLP-1R in the trigeminal nucleus caudalis suppresses central sensitization of chronic migraine after recurrent nitroglycerin stimulation

期刊: JOURNAL OF HEADACHE AND PAIN, 2021; 22 (1)

Background Central sensitization is considered a critical pathogenic mechanism of chronic migraine (CM). Activation of microglia in the trigeminal nuc......

Assessment of normalized cerebral blood flow and its connectivity with migraines without aura during interictal periods by arterial spin labeling

期刊: JOURNAL OF HEADACHE AND PAIN, 2021; 22 (1)

BackgroundMigraine constitutes a global health burden, and its pathophysiology is not well-understood; research evaluating cerebral perfusion and alte......

Flatness of the Meckel cave may cause primary trigeminal neuralgia: a radiomics-based study

期刊: JOURNAL OF HEADACHE AND PAIN, 2021; 22 (1)

Background Neurovascular contact (NVC) is the main cause of primary trigeminal neuralgia (PTN); however, cases of PTN without NVC are still observed. ......

Altered amygdala effective connectivity in migraine without aura: evidence from resting-state fMRI with Granger causality analysis

期刊: JOURNAL OF HEADACHE AND PAIN, 2021; 22 (1)

Background Granger causality analysis (GCA) has been used to investigate the pathophysiology of migraine. Amygdala plays a key role in pain modulation......

Repeated oxytocin prevents central sensitization by regulating synaptic plasticity via oxytocin receptor in a chronic migraine mouse model

期刊: JOURNAL OF HEADACHE AND PAIN, 2021; 22 (1)

Background Central sensitization is one of the characters of chronic migraine (CM). Aberrant synaptic plasticity can induce central sensitization. Oxy......

Functional correlation of ATP1A2 mutations with phenotypic spectrum: from pure hemiplegic migraine to its variant forms

期刊: JOURNAL OF HEADACHE AND PAIN, 2021; 22 (1)

Background Mutations in ATP1A2, the gene encoding the alpha 2 subunit of Na+/K+-ATPase, are the main cause of familial hemiplegic migraine type 2 (FHM......

Aberrant cerebral blood flow in tinnitus patients with migraine: a perfusion functional MRI study

期刊: JOURNAL OF HEADACHE AND PAIN, 2021; 22 (1)

Purpose Migraine is often accompanied with chronic tinnitus that will affect the cerebral blood flow (CBF) and exacerbate the tinnitus distress. Howev......

Whole-brain morphological alterations associated with trigeminal neuralgia

期刊: JOURNAL OF HEADACHE AND PAIN, 2021; 22 (1)

Background Novel neuroimaging strategies have the potential to offer new insights into the mechanistic basis for trigeminal neuralgia (TN). The presen......

The sensitivity to change of the cluster headache quality of life scale assessed before and after deep brain stimulation of the ventral tegmental area

期刊: JOURNAL OF HEADACHE AND PAIN, 2021; 22 (1)

Background Cluster headache (CH) is a trigeminal autonomic cephalalgia (TAC) characterized by a highly disabling headache that negatively impacts qual......

Structured Q1 headache services as the solution to the ill-health burden of headache: 1. Rationale and description

期刊: JOURNAL OF HEADACHE AND PAIN, 2021; 22 (1)

In countries where headache services exist at all, their focus is usually on specialist (tertiary) care. This is clinically and economically inappropr......

Different dosage regimens of Eptinezumab for the treatment of migraine: a meta-analysis from randomized controlled trials

期刊: JOURNAL OF HEADACHE AND PAIN, 2021; 22 (1)

Background: Migraine is one of the most common neurological diseases around the world and calcitonin gene-related peptide (CGRP) plays an important ro......

Prevalence and risk factors associated with Chick for headache amongst medical staff in South updates China

期刊: JOURNAL OF HEADACHE AND PAIN, 2020; 21 (1)

Background: A previous study by our team reported the prevalence of primary headache disorders and factors associated with headache among nurses in th......

Microglia P2X4R-BDNF signalling contributes to central sensitization in a recurrent nitroglycerin-induced chronic migraine model

期刊: JOURNAL OF HEADACHE AND PAIN, 2020; 21 (1)

Background: According to our previous study, microglia P2X4 receptors (P2X4Rs) play a pivotal role in the central sensitization of chronic migraine (C......

Genetic variants in migraine: a field synopsis and systematic re-analysis of meta-analyses

期刊: JOURNAL OF HEADACHE AND PAIN, 2020; 21 (1)

Objective Numerous genetic variants from meta-analyses of observational studies and GWAS were reported to be associated with migraine susceptibility. ......

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