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Posttranslational modification and beyond: interplay between histone deacetylase 6 and heat-shock protein 90

期刊: MOLECULAR MEDICINE, 2021; 27 (1)

Posttranslational modification (PTM) and regulation of protein stability are crucial to various biological processes. Histone deacetylase 6 (HDAC6), a......

MicroRNA-214 promotes alveolarization in neonatal rat models of bronchopulmonary dysplasia via the PlGF-dependent STAT3 pathway

期刊: MOLECULAR MEDICINE, 2021; 27 (1)

Background Recently, the role of several microRNAs (miRNAs or miRs) in pulmonary diseases has been described. The molecular mechanisms by which miR-21......

Interleukin-22: a potential therapeutic target in atherosclerosis

期刊: MOLECULAR MEDICINE, 2021; 27 (1)

Background Atherosclerosis is recognized as a chronic immuno-inflammatory disease that is characterized by the accumulation of immune cells and lipids......

CircRNAs and their regulatory roles in cancers

期刊: MOLECULAR MEDICINE, 2021; 27 (1)

Circular RNAs (circRNAs), a novel type of non-coding RNAs (ncRNAs), have a covalently closed circular structure resulting from pre-mRNA back splicing ......

LncRNA-Fendrr protects against the ubiquitination and degradation of NLRC4 protein through HERC2 to regulate the pyroptosis of microglia

期刊: MOLECULAR MEDICINE, 2021; 27 (1)

Objectives Targeted inhibition of inflammatory response can reduce diabetic cerebral ischemia-reperfusion (I/R) injure. Pyroptosis is characterized by......

MicroRNA regulation of the proliferation and apoptosis of Leydig cells in diabetes

期刊: MOLECULAR MEDICINE, 2021; 27 (1)

Background The number of patients with diabetes is increasing worldwide. Diabetic testicular damage can cause spermiogenesis disorders and sexual dysf......

Gastrin exerts a protective effect against myocardial infarction via promoting angiogenesis

期刊: MOLECULAR MEDICINE, 2021; 27 (1)

Background It is known that increased gastrin concentration is negatively correlated with cardiovascular mortality, and plasma gastrin levels are incr......

Propofol attenuates lung ischemia/reperfusion injury though the involvement of the MALAT1/microRNA-144/GSK3 beta axis

期刊: MOLECULAR MEDICINE, 2021; 27 (1)

Background: Propofol, an intravenous anesthetic, was proven to protect against lung ischemia/reperfusion (I/R) injury. However, the detailed mechanism......

Human umbilical cord mesenchymal stem cells deliver exogenous miR-26a-5p via exosomes to inhibit nucleus pulposus cell pyroptosis through METTL14/NLRP3

期刊: MOLECULAR MEDICINE, 2021; 27 (1)

Background Intervertebral disc degeneration (IVDD) is the breakdown of the discs supporting the vertebrae. It is one of the most frequent causes of ba......

Increased hemoglobin and heme in MALDI-TOF MS analysis induce ferroptosis and promote degeneration of herniated human nucleus pulposus

期刊: MOLECULAR MEDICINE, 2021; 27 (1)

Background Neovasculogenesis is characteristic of herniated lumbar discs, in which extruded nucleus pulposus is prone to heme iron-induced cytotoxicit......

Pinocembrin ameliorates post-infarct heart failure through activation of Nrf2/HO-1 signaling pathway

期刊: MOLECULAR MEDICINE, 2021; 27 (1)

Background Oxidative stress is an important factor involved in the progress of heart failure. The current study was performed to investigate whether p......

Breast cancer cell-derived extracellular vesicles transfer miR-182-5p and promote breast carcinogenesis via the CMTM7/EGFR/AKT axis

期刊: MOLECULAR MEDICINE, 2021; 27 (1)

BackgroundExtracellular vesicles (EVs) derived from tumor cells are implicated in the progression of malignancies through the transfer of molecular ca......

rAAV9-mediated supplementation of miR-29b improve angiotensin-II induced renal fibrosis in mice

期刊: MOLECULAR MEDICINE, 2021; 27 (1)

Background Renin-angiotensin-aldosterone system activation is the critical factor in renal remodeling and dysfunction. Our previous study suggested th......

Circular RNA-0007059 protects cell viability and reduces inflammation in a nephritis cell model by inhibiting microRNA-1278/SHP-1/STAT3 signaling

期刊: MOLECULAR MEDICINE, 2021; 27 (1)

Background Increasing evidence has indicated that circular RNAs (circRNAs) play a role in various diseases. However, the influence of circRNAs in neph......

Association of CASC18/miR-20a-3p/TGFB2 ceRNA axis with occult lymph node metastasis in tongue squamous cell carcinoma

期刊: MOLECULAR MEDICINE, 2021; 27 (1)

Background Tongue squamous cell carcinoma (TSCC) ranks as the most prevalent malignancy in the oral cavity. TSCC patients with occult lymph node metas......

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