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Monitor for lactate in perspiration

期刊: JOURNAL OF PHYSIOLOGICAL SCIENCES, 2021; 71 (1)

Sweat is a noninvasive biological fluid on the surface of human skin and has attracted increasing attention as a diagnostic specimen for disease and b......

The activation of galanin receptor 2 plays an antinociceptive effect in nucleus accumbens of rats with neuropathic pain

期刊: JOURNAL OF PHYSIOLOGICAL SCIENCES, 2021; 71 (1)

Our previous research has shown that galanin plays an antinociceptive effect via binding to galanin receptors (GalRs) in nucleus accumbens (NAc). This......

Long noncoding RNA CASC7 inhibits the proliferation and migration of papillary thyroid cancer cells by inhibiting miR-34a-5p

期刊: JOURNAL OF PHYSIOLOGICAL SCIENCES, 2021; 71 (1)

Long noncoding RNAs (lncRNAs) play an essential role in the progression of papillary thyroid cancer (PTC). However, the expression and function of lnc......

NK cell-derived exosomes improved lung injury in mouse model of Pseudomonas aeruginosa lung infection

期刊: JOURNAL OF PHYSIOLOGICAL SCIENCES, 2020; 70 (1)

Background Pseudomonas aeruginosa (PA) is one of the most common bacteria that causes lung infection in hospital. The aim of our study is to explore t......

Cardiac specific transcription factor Csx/Nkx2.5 regulates transient-outward K+ channel expression in pluripotent P19 cell-derived cardiomyocytes

期刊: JOURNAL OF PHYSIOLOGICAL SCIENCES, 2020; 70 (1)

The homeobox-containing gene Csx/Nkx2.5 codes several cardiac transcription factors and plays a critical role in early cardiogenesis. We investigated ......

Tolfenamic acid inhibits GSK-3 beta and PP2A mediated tau hyperphosphorylation in Alzheimer's disease models

期刊: JOURNAL OF PHYSIOLOGICAL SCIENCES, 2020; 70 (1)

Tolfenamic acid, a nonsteroidal anti-inflammatory drug, alleviated learning and memory deficits and decreased the expression of specificity protein 1 ......

Tonic contraction develops in the colon during anaphylactic hypotension in anesthetized rats

期刊: JOURNAL OF PHYSIOLOGICAL SCIENCES, 2019; 69 (6)

Diarrhea is a gastrointestinal symptom associated with systemic anaphylaxis and could be induced by increased colonic motility. We determined colonic ......

JIF:3.34

Overexpression of calcitonin gene-related peptide protects mouse cerebral microvascular endothelial cells from high-glucose-induced damage via ERK/HIF-1/VEGF signaling

期刊: JOURNAL OF PHYSIOLOGICAL SCIENCES, 2019; 69 (6)

In the diabetic brain, hyperglycemia damages the cerebrovasculature and impairs neurovascular crosstalk. Calcitonin gene-related peptide (CGRP) is an ......

JIF:3.34

Long-term moderate intensity exercise alleviates myocardial fibrosis in type 2 diabetic rats via inhibitions of oxidative stress and TGF-beta 1/Smad pathway

期刊: JOURNAL OF PHYSIOLOGICAL SCIENCES, 2019; 69 (6)

Exercise has an effect on the reduction of myocardial fibrosis in diabetic rats as previously reported, in which oxidative stress and the TGF-beta 1/S......

JIF:3.34

Mst1 promotes cardiac ischemia-reperfusion injury by inhibiting the ERK-CREB pathway and repressing FUNDC1-mediated mitophagy

期刊: JOURNAL OF PHYSIOLOGICAL SCIENCES, 2019; 69 (1)

Cardiac ischemia-reperfusion (I/R) injury results mainly from mitochondrial dysfunction and cardiomyocyte death. Mitophagy sustains mitochondrial func......

JIF:3.34

Asparagine-linked glycosylation modifies voltage-dependent gating properties of Ca(V)3.1-T-type Ca2+ channel

期刊: JOURNAL OF PHYSIOLOGICAL SCIENCES, 2019; 69 (2)

T-type channels are low-voltage-activated channels that play a role in the cardiovascular system particularly for pacemaker activity. Glycosylation is......

JIF:3.34

Matrine has pro-apoptotic effects on liver cancer by triggering mitochondrial fission and activating Mst1-JNK signalling pathways

期刊: JOURNAL OF PHYSIOLOGICAL SCIENCES, 2019; 69 (2)

Mitochondrial homeostasis is closely associated with liver cancer progression via multiple mechanisms and is also a potential tumour-suppressive targe......

JIF:3.34

Suramin protects hepatocytes from LPS-induced apoptosis by regulating mitochondrial stress and inactivating the JNK-Mst1 signaling pathway

期刊: JOURNAL OF PHYSIOLOGICAL SCIENCES, 2019; 69 (3)

An uncontrolled inflammatory response has been implicated in the progression of acute liver failure through poorly understood mechanisms. The aim of o......

JIF:3.34

Xanthoceraside prevented synaptic loss and reversed learning-memory deficits in APP/PS1 transgenic mice

期刊: JOURNAL OF PHYSIOLOGICAL SCIENCES, 2019; 69 (3)

Xanthoceraside, a novel triterpenoid saponin, has been found to attenuate learning and memory impairments in AD animal models. However, whether xantho......

JIF:3.34

Natural silibinin modulates amyloid precursor protein processing and amyloid-beta protein clearance in APP/PS1 mice

期刊: JOURNAL OF PHYSIOLOGICAL SCIENCES, 2019; 69 (4)

Silibinin has been shown to attenuate cognitive dysfunction and inhibit amyloid-beta (A beta) aggregation in Alzheimer's disease (AD) models. However,......

JIF:3.34

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