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Dexmedetomidine attenuates one-lung ventilation associated lung injury by suppressing inflammatory responses: A systematic review and meta-analysis

期刊: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2021; 48 (9)

One-lung ventilation (OLV), a common ventilation technique, is associated with perioperative lung injury, tightly connected with inflammatory response......

An update of genetics, co-morbidities and management of hyperuricaemia

期刊: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2021; 48 (10)

Hyperuricaemia (HU) caused by disorders of purine metabolism is a metabolic disease. A number of epidemiological reports have confirmed that HU is cor......

Low field magnetic stimulation promotes myelin repair and cognitive recovery in chronic cuprizone mouse model

期刊: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2021; 48 (8)

Background Multiple sclerosis (MS) is an inflammatory demyelinating disease featured with neuroinflammation, demyelination, and the loss of oligodendr......

Reversible bronchial dilatation in adults

期刊: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2021; 48 (7)

Bronchiectasis is characterized by the destruction of bronchial wall and persistent irreversible bronchiectasis due to respiratory infection and bronc......

Sodium butyrate ameliorates non-alcoholic fatty liver disease by upregulating miR-150 to suppress CXCR4 expression

期刊: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2021; 48 (8)

Sodium butyrate (NaB) in the gut of animals possesses the potential to modulate lipid metabolism, regulate innate immunity and protect intestinal heal......

LncRNA Miat knockdown alleviates endothelial cell injury through regulation of miR-214-3p/Caspase-1 signalling during atherogenesis

期刊: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2021; 48 (9)

Atherosclerosis is a common problem in healthy people around the world. Long noncoding RNAs (lncRNAs) play important roles in atherosclerosis. Myocard......

Potential of crocodile blood as a medication and dietary supplement: A systemic review

期刊: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2021; 48 (8)

Crocodile blood has long been used as a traditional medicine in many Asian countries to treat diseases such as asthma, allergies, and many others. Yet......

Atorvastatin reverses high cholesterol-induced cardiac remodelling and regulates mitochondrial quality-control in a cholesterol-independent manner: An experimental study

期刊: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2021; 48 (8)

Mitochondria are key regulators of cell fate, maintaining self-stability by a fine-tuned quality-control network including mitophagy, biogenesis, fiss......

Effect of BTP2 on agonist-induced vasoconstriction in the mouse aorta in vitro

期刊: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2021; 48 (5)

BTP2 is a potent inhibitor of store-operated Ca2+ entry (SOCE), which plays a vital role in vasoconstriction. However, the direct effect of BTP2 on th......

Circ_0093887 upregulates CCND2 and SUCNR1 to inhibit the ox-LDL-induced endothelial dysfunction in atherosclerosis by functioning as a miR-876-3p sponge

期刊: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2021; 48 (8)

Circular RNAs (circRNAs) are widely expressed in mammals and act as regulatory targets in the atherogenesis. The objective of this study was to resear......

The circular RNA circ_GRHPR promotes NSCLC cell proliferation and invasion via interactions with the RNA-binding protein PCBP2

期刊: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2021; 48 (8)

As the most common malignancy, lung cancer is characterised by high rates of occurrence and mortality. Although circular RNAs (circRNAs) are known to ......

Mechanisms of cancer stem cell senescence: Current understanding and future perspectives

期刊: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2021; 48 (9)

Cancer stem cells (CSCs) are a small population of heterogeneous tumor cells with the capacity of self-renewal and aberrant differentiation for immort......

Moderate endurance training reduced hepatic tumourigenesis associated with lower lactate overload compared to high-intensity interval training

期刊: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2021; 48 (9)

The anti-tumour effects of exercise are still poorly understood. In recent years, high-intensity interval exercise has been recognised as one of the b......

Klotho inhibits H2O2-induced oxidative stress and apoptosis in periodontal ligament stem cells by regulating UCP2 expression

期刊: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2021; 48 (10)

Periodontitis, a human chronic inflammatory disease, has affected the lives of millions of individuals. Periodontal ligament stem cells (PDLSCs), deri......

Signalling pathway of U46619-induced vascular smooth muscle contraction in mouse coronary artery

期刊: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2021; 48 (7)

Background Thromboxane A(2) (TXA(2)) participates in many pathophysiological processes of coronary artery disease. However, its mechanism of TXA(2)-in......

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