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Overview of antiviral drug candidates targeting coronaviral 3C-like main proteases

期刊: FEBS JOURNAL, 2021; 288 (17)

Coronaviruses (CoVs) are positive single-stranded RNA viruses that cause severe respiratory syndromes in humans, including severe acute respiratory sy......

Identification of a special cell type as a determinant of the kidney tropism of SARS-CoV-2

期刊: FEBS JOURNAL, 2021; 288 (17)

The kidney tropism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been well-validated clinically and often leads to various forms......

Energy metabolism in brown adipose tissue

期刊: FEBS JOURNAL, 2021; 288 (12)

Brown adipose tissue (BAT) is well known to burn calories through uncoupled respiration, producing heat to maintain body temperature. This 'calorie wa......

Design and preparation of the class B G protein-coupled receptors GLP-1R and GCGR for F-19-NMR studies in solution

期刊: FEBS JOURNAL, ; ()

The human glucagon-like peptide-1 receptor (GLP-1R) and the glucagon receptor (GCGR) are class B G protein-coupled receptors (GPCRs) that are activate......

Function of pH-dependent transcription factor PacC in regulating development, pathogenicity, and mycotoxin biosynthesis of phytopathogenic fungi

期刊: FEBS JOURNAL, ; ()

pH, as one of the most important environmental factors, affects various biological processes in pathogenic fungi. Sensing and responding to fluctuatio......

Chromatin accessibility of kidney tubular cells under stress reveals key transcription factor mediating acute and chronic kidney disease

期刊: FEBS JOURNAL, ; ()

Cellular injury caused by stimuli plays an important role in the progression of various diseases including acute and chronic kidney diseases. The dyna......

The role of PARP1 in neurodegenerative diseases and aging

期刊: FEBS JOURNAL, ; ()

Neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD), are characterized by progressive memory loss and motor im......

ID1 inhibits foot-and-mouth disease virus replication via targeting of interferon pathways

期刊: FEBS JOURNAL, ; ()

Inhibitor of DNA-binding 1 (ID1) protein has been studied intensively for its functions in tumorigenesis and maintenance of stem cell-like properties,......

Tumor-associated macrophages in immunotherapy

期刊: FEBS JOURNAL, ; ()

Tumor-associated macrophages (TAMs) are essential components of the tumor microenvironment involved in the progression and metastasis of cancer. They ......

Revisiting preeclampsia: a metabolic disorder of the placenta

期刊: FEBS JOURNAL, ; ()

Preeclampsia (PE) is a leading cause of maternal and neonatal mortality and morbidity worldwide, impacting the long-term health of both mother and off......

FOXP3(+) regulatory T cells and age-related diseases

期刊: FEBS JOURNAL, ; ()

Regulatory T (Treg) cells are critical for the maintenance of immune homeostasis. Dysregulation of Treg cells has been implicated in the pathogenesis ......

LCDM medium supports the derivation of bovine extended pluripotent stem cells with embryonic and extraembryonic potency in bovine-mouse chimeras from iPSCs and bovine fetal fibroblasts

期刊: FEBS JOURNAL, ; ()

Cattle have emerged as one of the most important domestic animals widely used for meat, milk, and fur. Derivation of bovine pluripotent stem cells (PS......

Constitutive activity of GPR26 regulated by ubiquitin-dependent degradation and its antitumor role

期刊: FEBS JOURNAL, ; ()

G protein-coupled receptors (GPCRs) play important roles in many physiological functions and numerous diseases. In addition to the classic ligand-stim......

SOX9 in prostate cancer is upregulated by cancer-associated fibroblasts to promote tumor progression through HGF/c-Met-FRA1 signaling

期刊: FEBS JOURNAL, ; ()

Transcription factor SOX9 was a biomarker for prostate cancer (Pca) with poor prognosis. Nevertheless, the regulatory mechanism underlying SOX9 upregu......

Cryo-EM structures of the endoplasmic reticulum membrane complex

期刊: FEBS JOURNAL, ; ()

The transmembrane alpha-helices of membrane proteins are in general highly hydrophobic, and they enter the lipid bilayer through a lateral gate in the......

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