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Antibiotic-induced microbiome depletion in adult mice disrupts blood-brain barrier and facilitates brain infiltration of monocytes after bone-marrow transplantation

期刊: BRAIN BEHAVIOR AND IMMUNITY, 2021; 92 ()

The crosstalk between intestinal bacteria and the central nervous system, so called "the gut-brain axis", is critically important for maintaining brai......

Histamine-4 receptor antagonist ameliorates Parkinson-like pathology in the striatum

期刊: BRAIN BEHAVIOR AND IMMUNITY, 2021; 92 ()

Growing evidence indicates that microglia activation and a neuroinflammatory trigger contribute to dopaminergic cell loss in Parkinson's disease (PD).......

Glutaminase in microglia: A novel regulator of neuroinflammation

期刊: BRAIN BEHAVIOR AND IMMUNITY, 2021; 92 ()

Neuroinflammation is the inflammatory responses that are involved in the pathogenesis of most neurological disorders. Glutaminase (GLS) is the enzyme ......

Inflammatory cytokines, complement factor H and anhedonia in drug-naive major depressive disorder

期刊: BRAIN BEHAVIOR AND IMMUNITY, 2021; 95 ()

Objective: Anhedonia is a core symptom of major depressive disorder (MDD) and often associated with poor prognosis. The main objective of the present ......

Astrocytic Kir6.1 deletion aggravates neurodegeneration in the lipopolysaccharide-induced mouse model of Parkinson's disease via astrocyte-neuron cross talk through complement C3-C3R signaling

期刊: BRAIN BEHAVIOR AND IMMUNITY, 2021; 95 ()

Complement pathway over-activation has been implicated in a variety of neurological diseases. However, the signaling pathways governing astrocytic com......

Mannan oligosaccharide attenuates cognitive and behavioral disorders in the 5xFAD Alzheimer's disease mouse model via regulating the gut microbiota-brain axis

期刊: BRAIN BEHAVIOR AND IMMUNITY, 2021; 95 ()

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by cognitive deficits and psychiatric symptoms. The gut microbiota-b......

Expression of Cntn1 is regulated by stress and associated with anxiety and depression phenotypes

期刊: BRAIN BEHAVIOR AND IMMUNITY, 2021; 95 ()

In recent years, our understanding of neural circuits associated with depression has increased. Although inherited factors are known to influence indi......

Ghrelin modulates dopaminergic neuron formation and attention deficit hyperactivity disorder-like behaviors: From animals to human models

期刊: BRAIN BEHAVIOR AND IMMUNITY, 2021; 94 ()

Attention deficit hyperactivity disorder (ADHD) is one of the most prevalent psychiatric disorders in children. The orexigenic hormone ghrelin is impo......

Microglial IL-10 and beta-endorphin expression mediates gabapentinoids antineuropathic pain

期刊: BRAIN BEHAVIOR AND IMMUNITY, 2021; 95 ()

Gabapentinoids are recommended first-line treatments for neumpathic pain. They are neuronal voltage-dependent calcium channel alpha 2 delta-1 subunit ......

Down-regulation of MST1 in hippocampus protects against stress-induced depression-like behaviours and synaptic plasticity impairments

期刊: BRAIN BEHAVIOR AND IMMUNITY, 2021; 94 ()

Depression is a common mental disorder, and its main environmental risk factor is chronic stress. The activation of mammalian STE20-like kinase 1 (MST......

Delayed diapedesis of CD8 T cells contributes to long-term pathology after ischemic stroke in male mice

期刊: BRAIN BEHAVIOR AND IMMUNITY, 2021; 95 ()

Objective: Stroke is a debilitating disorder with significant annual mortality and morbidity rates worldwide. Immune cells are recruited to the injure......

Plasma exosomes from depression ameliorate inflammation-induced depressive-like behaviors via sigma-1 receptor delivery

期刊: BRAIN BEHAVIOR AND IMMUNITY, 2021; 94 ()

A growing body of studies indicated that exosomes are one of vital players in pathological process of neuropsychiatric diseases, but their role in maj......

Activation of liver X receptors prevents emotional and cognitive dysfunction by suppressing microglial M1-polarization and restoring synaptic plasticity in the hippocampus of mice

期刊: BRAIN BEHAVIOR AND IMMUNITY, 2021; 94 ()

Depression is a long-lasting and persistent mood disorder in which the regulatory mechanisms of neuroinflammation are thought to play a contributing r......

Microglia-derived interleukin-10 accelerates post-intracerebral hemorrhage hematoma clearance by regulating CD36

期刊: BRAIN BEHAVIOR AND IMMUNITY, 2021; 94 ()

Hematoma size after intracerebral hemorrhage (ICH) significantly affects patient outcome. However, our knowledge of endogenous mechanisms that underli......

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