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Kv4.2 phosphorylation by PKA drives Kv4.2-KChIP2 dissociation, leading to Kv4.2 out of lipid rafts and internalization

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2022; 323 (1)

Sympathetic regulation of the Kv4.2 transient outward potassium current (Ito) is critical for the acute electrical and contractile response of the myo......

JIF:3.452

Activation of dopamine D-2 receptor promotes pepsinogen secretion by suppressing somatostatin release from the mouse gastric mucosa

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2022; 322 (3)

In vivo administration of dopamine (DA) receptor (DR)-related drugs modulate gastric pepsinogen secretion. However, DRs on gastric pepsinogen-secretin......

JIF:3.452

Posttranslational modifications in GPCR internalization

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2022; 323 (1)

G protein-coupled receptors (GPCRs) are the largest family of membrane receptors that serve as the most important drug targets. Classically, GPCR inte......

JIF:3.452

Role of glycolysis in the development of atherosclerosis

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2022; 323 (2)

Atherosclerosis is a chronic inflammatory vascular disease associated with endothelial dysfunction, inflammation, and atherosclerotic plaque formation......

JIF:3.452

Role of hepatic lipid species in the progression of nonalcoholic fatty liver disease

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2022; 323 (2)

Nonalcoholic fatty liver disease (NAFLD) has become the most common liver disease due to the global pandemic of metabolic dis-eases. Dysregulation of ......

JIF:3.452

GRK2 promotes activation of lung fibroblast cells and contributes to pathogenesis of pulmonary fibrosis through increasing Smad3 expression

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2022; 322 (1)

Pulmonary fibrosis is a chronic, progressive, and irreversible interstitial lung disease. Transforming growth factor-81 (TGF-81) plays a major role in......

JIF:3.452

Emerging roles of HMGB1-related lncRNA: from molecular biology to clinical application

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2022; 323 (4)

High-mobility group box 1 (HMGB1) not only induces cell proliferation and migration but also promotes cell apoptosis and autophagy. Abnormal expressio......

JIF:3.452

Circadian clock regulates granulosa cell autophagy through NR1D1-mediated inhibition of ATG5

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2022; 322 (2)

Autophagy of granulosa cells (GCs) is involved in follicular atresia, which occurs repeatedly during the ovarian development cycle. Several circadian ......

JIF:3.452

ASH1L contributes to oocyte apoptosis by regulating DNA damage

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2022; 323 (4)

In female mammals, the size of the initially established primordial follicle pool within the ovaries determines the reproductive life span. Interestin......

JIF:3.452

Structural and conformational studies of biased agonism through formyl peptide receptors

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2022; 322 (5)

G protein-coupled chemoattractant receptors are class A GPCRs that couple primarily to the Gi class of heterotrimeric G proteins. Initially identified......

JIF:3.452

Aerobic exercise and resistance exercise alleviate skeletal muscle atrophy through IGF-1/IGF-1R-PI3K/Akt pathway in mice with myocardial infarction

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2022; 322 (2)

Myocardial infarction (MI)-induced heart failure (HF) is commonly accompanied with profound effects on skeletal muscle. With the process of MI-induced......

JIF:3.452

Ferroptosis at the crossroads of tumor-host interactions, metastasis, and therapy response

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2022; 323 (1)

Ferroptosis is a form of regulated cell death characterized by the accumulation of lipid peroxides in an iron-dependent manner. Ferroptotic cell death......

JIF:3.452

The regulating pathway of creatine on muscular protein metabolism depends on the energy state

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2022; 322 (5)

Creatine (Cr) is beneficial for increasing muscle mass and preventing muscle atrophy via involving in energy metabolism through the Cr and phosphocrea......

JIF:3.452

Rac1 regulates nucleus pulposus cell degeneration by activating the Wnt/beta-catenin signaling pathway and promotes the progression of intervertebral disc degeneration

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2022; 322 (3)

Nucleus pulposus cell (NPC) dysfunction is considered as an important event related to intervertebral disc degeneration (IVDD). In the present study, ......

JIF:3.452

IL-17A contributes to skeletal muscle atrophy in lung cancer-induced cachexia via JAK2/STAT3 pathway

期刊: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2022; 322 (5)

Cachexia is a complex metabolic syndrome that occurs in approximately 50% of patients with cancer. Skeletal muscle atrophy is the primary clinical fea......

JIF:3.452

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