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The value of small airway function parameters and fractional exhaled nitric oxide for predicting positive methacholine challenge test in asthmatics of different ages with FEV1 >= 80% predicted

期刊: CLINICAL AND TRANSLATIONAL ALLERGY, 2021; 11 (1)

Background Small airway function parameters (SAFPs) combined with fractional exhaled nitric oxide (FeNO) can predict a positive methacholine challenge......

Anaphylactic risk related to omalizumab, benralizumab, reslizumab, mepolizumab, and dupilumab

期刊: CLINICAL AND TRANSLATIONAL ALLERGY, 2021; 11 (4)

Background Monoclonal antibodies (mAbs) are novel, effective therapeutics for the treatment of inadequately controlled severe asthma. Knowledge of the......

Peach allergen Pru p 1 content is generally low in fruit but with large variation in different varieties

期刊: CLINICAL AND TRANSLATIONAL ALLERGY, 2021; 11 (3)

Background Pru p 1 is a major allergen in peach and nectarine, and the different content in varieties may affect the degree of allergic reactions. Thi......

Dynamic trends in skin barrier function from birth to age 6 months and infantile atopic dermatitis: A Chinese prospective cohort study

期刊: CLINICAL AND TRANSLATIONAL ALLERGY, 2021; 11 (5)

Background Skin barrier functions develop after birth and may be related to skin disorders in infants. We aimed to assess associations between dynamic......

IL-19 induced by IL-13/IL-17A in the nasal epithelium of patients with chronic rhinosinusitis upregulates MMP-9 expression via ERK/NF-kappa B signaling pathway

期刊: CLINICAL AND TRANSLATIONAL ALLERGY, 2021; 11 (1)

Background Tissue remodeling is a crucial characteristic of chronic rhinosinusitis (CRS). Imbalance between matrix metalloproteinases (MMPs) and tissu......

Budesonide repairs decreased barrier integrity of eosinophilic nasal polyp epithelial cells caused by PM2.5

期刊: CLINICAL AND TRANSLATIONAL ALLERGY, 2021; 11 (5)

Background Eosinophilic chronic rhinitis with nasal polyps (eos-CRSwNP) is a subtype of nasal polyps (NPs) characterized by severe type-2 inflammation......

Long-term safety and effectiveness of berotralstat for hereditary angioedema: The open-label APeX-S study

期刊: CLINICAL AND TRANSLATIONAL ALLERGY, 2021; 11 (4)

Background Berotralstat (BCX7353) is an oral, once-daily inhibitor of plasma kallikrein recently approved for prevention of angioedema attacks in adul......

Current pet ownership modifies the adverse association between long-term ambient air pollution exposure and childhood asthma

期刊: CLINICAL AND TRANSLATIONAL ALLERGY, 2021; 11 (1)

Background Recent studies suggest that household endotoxin and allergens can modify the impact of air pollutants on development of asthma; however, ep......

A novel ELISA method to determine human MrgX2 in chronic urticaria

期刊: CLINICAL AND TRANSLATIONAL ALLERGY, 2020; 10 (1)

Background Mas-related G-protein coupled receptor member X2 (MrgX2) directly mediates drug-induced pseudo allergic reactions. Skin mast cell MrgX2 is ......

Treatment of allergic rhinitis during and outside the pollen season using mobile technology. A MASK study

期刊: CLINICAL AND TRANSLATIONAL ALLERGY, 2020; 10 (1)

Background The analysis of mobile health (mHealth) data has generated innovative insights into improving allergic rhinitis control, but additive infor......

Variation in IgE binding potencies of seven Artemisia species depending on content of major allergens

期刊: CLINICAL AND TRANSLATIONAL ALLERGY, 2020; 10 (1)

Background Artemisia weed pollen allergy is important in the northern hemisphere. While over 350 species of this genus have been recorded, there has b......

Increasing incidence of anaphylaxis in Hong Kong from 2009 to 2019-discrepancies of anaphylaxis care between adult and paediatric patients

期刊: CLINICAL AND TRANSLATIONAL ALLERGY, 2020; 10 (1)

Background Anaphylaxis has been increasing in developed countries but there is very little published data on the burden of anaphylaxis and the pattern......

Hereditary angioedema caused by a premature stop codon mutation in the SERPING1 gene

期刊: CLINICAL AND TRANSLATIONAL ALLERGY, 2020; 10 (1)

Background Hereditary angioedema with deficient and dysfunctional C1 inhibitor (C1-INH-HAE) is a rare genetic disorder. The majority of the cases with......

Distinct type 2-high inflammation associated molecular signatures of chronic rhinosinusitis with nasal polyps with comorbid asthma

期刊: CLINICAL AND TRANSLATIONAL ALLERGY, 2020; 10 (1)

Background Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and comorbid asthma have more severe disease and are difficult to treat. Ho......

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