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Traditional and emerging therapies for anaplastic large cell lymphoma (Review)

期刊: INTERNATIONAL JOURNAL OF ONCOLOGY, 2021; 59 (1)

Anaplastic large cell lymphoma (ALCL) is a rare and highly invasive non-Hodgkin's lymphoma. In the past few decades, traditional chemotherapy regimens......

Potential of the tumor-derived extracellular vesicles carrying the miR-125b-5p target TNFAIP3 in reducing the sensitivity of diffuse large B cell lymphoma to rituximab

期刊: INTERNATIONAL JOURNAL OF ONCOLOGY, 2021; 58 (6)

Diffuse large B-cell lymphoma (DLBCL) is the most common and aggressive form of non-Hodgkin's lymphoma. Extracellular vesicles (EVs) derived from canc......

MicroRNA-153-3p suppresses retinoblastoma cell growth and invasion via targeting the IGF1R/Raf/MEK and IGF1R/PI3K/AKT signaling pathways

期刊: INTERNATIONAL JOURNAL OF ONCOLOGY, 2021; 59 (1)

Mounting evidence has demonstrated that microRNAs (miRNAs or miRs) play significant roles in various types of human tumors, including retinoblastoma (......

Downregulated expression of IL-28RA is involved in the pathogenesis of pancreatic ductal adenocarcinoma

期刊: INTERNATIONAL JOURNAL OF ONCOLOGY, 2021; 59 (2)

Pancreatic cancer ranks seventh in terms of cancer-related mortality in men and women worldwide, where the most common subtype is pancreatic ductal ad......

Exosomal transfer of miR-25-3p promotes the proliferation and temozolomide resistance of glioblastoma cells by targeting FBXW7

期刊: INTERNATIONAL JOURNAL OF ONCOLOGY, 2021; 59 (2)

Intrinsic or acquired resistance to temozolomide (TMZ) is a frequent occurrence in patients with glioblastoma (GBM). Accumulating evidence has indicat......

Immunological modulation of the Th1/Th2 shift by ionizing radiation in tumors (Review)

期刊: INTERNATIONAL JOURNAL OF ONCOLOGY, 2021; 59 (1)

Extensive evidence has documented that the balance between cytokines from T helper type 1 (Th1) and type 2 (Th2) cells is disrupted in the tumorigenic......

Sequestosome 1/p62: A multitasker in the regulation of malignant tumor aggression (Review)

期刊: INTERNATIONAL JOURNAL OF ONCOLOGY, 2021; 59 (4)

Sequestosome 1 (SQSTM1)/p62 is an adapter protein mainly involved in the transportation, degradation and destruction of various proteins that cooperat......

CXCR4 blockade sensitizes osteosarcoma to doxorubicin by inducing autophagic cell death via PI3K-Akt-mTOR pathway inhibition

期刊: INTERNATIONAL JOURNAL OF ONCOLOGY, 2021; 59 (1)

Doxorubicin is one of the most frequently used chemotherapy drugs in the treatment of osteosarcoma (OS), but the emergence of chemoresistance often le......

Novel insights into the impact of the SUMOylation pathway in hematological malignancies (Review)

期刊: INTERNATIONAL JOURNAL OF ONCOLOGY, 2021; 59 (3)

The small ubiquitin-like modifier (SUMO) system serves an important role in the regulation of protein stability and function. SUMOylation sustains the......

SEPT6 drives hepatocellular carcinoma cell proliferation, migration and invasion via the Hippo/YAP signaling pathway

期刊: INTERNATIONAL JOURNAL OF ONCOLOGY, 2021; 58 (6)

Septin 6 (SEPT6) is a member of the GTP-binding protein family that is highly conserved in eukaryotes and regulates various biological functions, incl......

lncRNA HCP5 acts as a ceRNA to regulate EZH2 by sponging miR-138-5p in cutaneous squamous cell carcinoma

期刊: INTERNATIONAL JOURNAL OF ONCOLOGY, 2021; 59 (2)

Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are essential for the progression of tumors, including cutaneous squamous cell carcinoma (CSCC).......

lncRNA NEAT1 facilitates the progression of colorectal cancer via the KDM5A/Cul4A and Wnt signaling pathway

期刊: INTERNATIONAL JOURNAL OF ONCOLOGY, 2021; 59 (1)

Colorectal cancer (CRC) is a major cause of cancer-related mortality. The aberrant expression of long non-coding RNAs (lncRNAs) is implicated in the p......

The role of non-coding RNAs in the regulation, diagnosis, prognosis and treatment of osteosarcoma (Review)

期刊: INTERNATIONAL JOURNAL OF ONCOLOGY, 2021; 59 (3)

Osteosarcoma (OS) is the most common primary bone tumor worldwide. OS exhibits a range of aggressive behaviors, including early metastasis potential, ......

QPCT regulation by CTCF leads to sunitinib resistance in renal cell carcinoma by promoting angiogenesis

期刊: INTERNATIONAL JOURNAL OF ONCOLOGY, 2021; 59 (1)

Sunitinib is widely used as a first-line treatment for advanced renal cell carcinoma (RCC). However, a number of patients with RCC who receive sunitin......

MicroRNA-198 suppresses tumour growth and metastasis in oral squamous cell carcinoma by targeting CDK4

期刊: INTERNATIONAL JOURNAL OF ONCOLOGY, 2021; 59 (1)

MicroRNAs (miRNAs/miR) often contribute to the progression of oral squamous cell carcinoma (OSCC) via the regulation of mRNA. The present study aimed ......

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