期刊： BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2021; 87 (8)
Aims: To develop a physiologically based pharmacokinetic (PBPK) model for apixaban, an oral anticoagulant with a narrow therapeutic index, and to pred......
期刊： BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2021; 87 (7)
Background Tigecycline has been widely used to treat hospital-acquired pneumonia (HAP) off-label since it is effective against a wide range of multidr......
期刊： BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2021; 87 (9)
Aims The multipart Unified Parkinson's Disease Rating Scale is the standard instrument in clinical trials. A sum of scores for all items in 1 or more ......
期刊： BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2021; 87 (7)
Aims This study aims to develop and verify a physiologically based pharmacokinetic (PBPK) population model for the Chinese geriatric population in Sim......
期刊： BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, ; ()
Aims Pharmacokinetic equations, which relate different parameters of a single individual, are often applied to reported mean parameter-values, with th......
期刊： BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, ; ()
Aims Recently, letrozole has been used off-label to treat short pubertal boys. The experience on letrozole effectiveness and safety has been obtained ......
期刊： BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, ; ()
Aim Several studies have reported population pharmacokinetic models for phenobarbital (PB), but the predictive performance of these models has not bee......
期刊： BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, ; ()
Aims This study aimed to assess the impact of pharmacist-led medication therapy management (MTM) performed on ambulatory elderly patients with chronic......
期刊： BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, ; ()
Aims This open-label, phase I study evaluated the pharmacokinetics and safety of pegylated recombinant human granulocyte colony-stimulating factor (PE......
期刊： BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2020; 86 (9)
Aims We investigated the impacts of CYP2C19 polymorphisms on pharmacokinetics and pharmacodynamics of vicagrel in healthy Chinese subjects. Methods CY......
期刊： BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2020; 86 (8)
Aims Even though the use of direct oral anticoagulants (DOACs) is safe based on clinical outcomes, drug safety also depends on appropriateness of drug......
期刊： BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2020; 86 (8)
Aims Hetrombopag olamine is a novel small-molecule, nonpeptide thrombopoietin receptor agonist developed for immune thrombocytopenia treatment. This s......
期刊： BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2020; 86 (2)
Aims The aim of the study was to compare the pharmacokinetics (PK), safety and tolerability of secukinumab with different devices for subcutaneous (s.......
