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DNA methylation age acceleration is associated with age of onset in Chinese spinocerebellar ataxia type 3 patients

期刊: NEUROBIOLOGY OF AGING, 2022; 113 ()

Spinocerebellar ataxia type 3 (SCA3), also known as Machado Joseph disease (MJD), is a common dom-inantly inherited ataxia, and has heterogeneous clin......

JIF:4.36

Genome-wide association study of brain tau deposition as measured by 18F-flortaucipir positron emission tomography imaging

期刊: NEUROBIOLOGY OF AGING, 2022; 120 ()

The related genetic variants of tau deposition, a seminal pathological hallmark of Alzheimer's disease, remain poorly understood. We sought to perform......

JIF:4.36

Progressive alteration of dynamic functional connectivity patterns in subcortical ischemic vascular cognitive impairment patients

期刊: NEUROBIOLOGY OF AGING, 2022; 122 ()

Alterations in the temporal evolution of brain states in the process of cognitive impairment aggrava-tion due to subcortical ischemic vascular disease......

JIF:4.36

Evaluating the role of ARSA in Chinese patients with Parkinson's disease

期刊: NEUROBIOLOGY OF AGING, 2022; 109 ()

Recent studies have suggested ARSA, a gene responsible for metachromatic leukodystrophy, could be a genetic modifier of Parkinson's disease (PD) patho......

JIF:4.36

Intermediate-length CGG repeat expansion in NOTCH2NLC is associated with pathologically confirmed Alzheimer's disease

期刊: NEUROBIOLOGY OF AGING, 2022; 120 ()

Alzheimer's disease (AD) is the most common cause of dementia in the elderly. Pathologically, it is characterized by ,B-amyloid plaques and neurofibri......

JIF:4.36

C-reactive protein and risk of Alzheimer's disease

期刊: NEUROBIOLOGY OF AGING, 2022; 109 ()

In this study, we examined whether C-reactive protein (CRP) play causal roles in Alzheimer's disease (AD) using Mendelian randomization (MR) analysis.......

JIF:4.36

Enrichment of rare variants in E3 ubiquitin ligase genes in Early onset Parkinson's disease

期刊: NEUROBIOLOGY OF AGING, 2022; 109 ()

Altered ubiquitin signaling and disrupted protein quality control have been implicated in the pathogenesis of PD. The aim of the study was to systemat......

JIF:4.36

PSEN1 G417S mutation in a Chinese pedigree causing early-onset parkinsonism with cognitive impairment

期刊: NEUROBIOLOGY OF AGING, 2022; 115 ()

Presenilin 1 (PSEN1) mutations are a major cause of familial Alzheimer's disease. The pathogenic variant, PSEN1 p.G417S, has been reported to be assoc......

JIF:4.36

ANXA1 and the risk for early-onset Parkinson's disease

期刊: NEUROBIOLOGY OF AGING, 2022; 112 ()

Recently, homozygous missense variants in ANXA1 were identified to cause parkinsonism by segregation analysis in a consanguineous family. However, no ......

JIF:4.36

Loss of SST and PV positive interneurons in the ventral hippocampus results in anxiety-like behavior in 5xFAD mice

期刊: NEUROBIOLOGY OF AGING, 2022; 117 ()

Neuropsychiatric symptoms, such as anxiety and depression often appear early in patients with Alzheimer's disease (AD), and a comorbid, anxiety-like p......

JIF:4.36

Association and interaction of TOMM40 and PVRL2 with plasma amyloid- ? and Alzheimer?s disease among Chinese older adults: a population-based study

期刊: NEUROBIOLOGY OF AGING, 2022; 113 ()

Genetic studies have identified Alzheimer's disease (AD)-associated SNPs in TOMM40 and PVRL2 genes, but the underlying mechanisms remain unknown. We e......

JIF:4.36

Low-frequency and rare coding variants of NUS1 contribute to susceptibility and phenotype of Parkinson's disease

期刊: NEUROBIOLOGY OF AGING, 2022; 110 ()

NUS1 has been recently identified as a candidate gene for Parkinson's disease (PD). Few studies have examined the association of NUS1 variants with PD......

JIF:4.36

Variants in the Niemann-pick type C genes are not associated with Alzheimer's disease: a large case-control study in the Chinese population

期刊: NEUROBIOLOGY OF AGING, 2022; 116 ()

Despite the similar clinical and pathological features between Niemann-Pick type C (NPC) disease and Alzheimer's disease (AD), few studies have invest......

JIF:4.36

Gene-based burden analysis of damaging private variants in PRKN, PARK7 and PINK1 in Parkinson's disease cohorts of European descent

期刊: NEUROBIOLOGY OF AGING, 2022; 119 ()

Recessive mutations in PRKN, PARK7, and PINK1 are established causes of early-onset Parkinson's disease (EOPD). Previous studies have interrogated the......

JIF:4.36

Validation of the pathogenic role of rare DNAJC7 variants in Chinese patients with amyotrophic lateral sclerosis

期刊: NEUROBIOLOGY OF AGING, 2021; 106 ()

DNAJC7 has recently been recognized as a novel amyotrophic lateral sclerosis (ALS) risk gene. To date, few studies have screened DNAJC7 mutations in C......

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