期刊: NEUROBIOLOGY OF AGING, 2022; 113 ()
Spinocerebellar ataxia type 3 (SCA3), also known as Machado Joseph disease (MJD), is a common dom-inantly inherited ataxia, and has heterogeneous clin......
期刊: NEUROBIOLOGY OF AGING, 2022; 120 ()
The related genetic variants of tau deposition, a seminal pathological hallmark of Alzheimer's disease, remain poorly understood. We sought to perform......
期刊: NEUROBIOLOGY OF AGING, 2022; 122 ()
Alterations in the temporal evolution of brain states in the process of cognitive impairment aggrava-tion due to subcortical ischemic vascular disease......
期刊: NEUROBIOLOGY OF AGING, 2022; 109 ()
Recent studies have suggested ARSA, a gene responsible for metachromatic leukodystrophy, could be a genetic modifier of Parkinson's disease (PD) patho......
期刊: NEUROBIOLOGY OF AGING, 2022; 120 ()
Alzheimer's disease (AD) is the most common cause of dementia in the elderly. Pathologically, it is characterized by ,B-amyloid plaques and neurofibri......
期刊: NEUROBIOLOGY OF AGING, 2022; 109 ()
In this study, we examined whether C-reactive protein (CRP) play causal roles in Alzheimer's disease (AD) using Mendelian randomization (MR) analysis.......
期刊: NEUROBIOLOGY OF AGING, 2022; 109 ()
Altered ubiquitin signaling and disrupted protein quality control have been implicated in the pathogenesis of PD. The aim of the study was to systemat......
期刊: NEUROBIOLOGY OF AGING, 2022; 115 ()
Presenilin 1 (PSEN1) mutations are a major cause of familial Alzheimer's disease. The pathogenic variant, PSEN1 p.G417S, has been reported to be assoc......
期刊: NEUROBIOLOGY OF AGING, 2022; 112 ()
Recently, homozygous missense variants in ANXA1 were identified to cause parkinsonism by segregation analysis in a consanguineous family. However, no ......
期刊: NEUROBIOLOGY OF AGING, 2022; 117 ()
Neuropsychiatric symptoms, such as anxiety and depression often appear early in patients with Alzheimer's disease (AD), and a comorbid, anxiety-like p......
期刊: NEUROBIOLOGY OF AGING, 2022; 113 ()
Genetic studies have identified Alzheimer's disease (AD)-associated SNPs in TOMM40 and PVRL2 genes, but the underlying mechanisms remain unknown. We e......
期刊: NEUROBIOLOGY OF AGING, 2022; 110 ()
NUS1 has been recently identified as a candidate gene for Parkinson's disease (PD). Few studies have examined the association of NUS1 variants with PD......
期刊: NEUROBIOLOGY OF AGING, 2022; 116 ()
Despite the similar clinical and pathological features between Niemann-Pick type C (NPC) disease and Alzheimer's disease (AD), few studies have invest......
期刊: NEUROBIOLOGY OF AGING, 2022; 119 ()
Recessive mutations in PRKN, PARK7, and PINK1 are established causes of early-onset Parkinson's disease (EOPD). Previous studies have interrogated the......
期刊: NEUROBIOLOGY OF AGING, 2021; 106 ()
DNAJC7 has recently been recognized as a novel amyotrophic lateral sclerosis (ALS) risk gene. To date, few studies have screened DNAJC7 mutations in C......