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Feasibility Study of a Novel Transcatheter Tricuspid Annuloplasty System in a Porcine Model

期刊: JACC-BASIC TO TRANSLATIONAL SCIENCE, 2022; 7 (6)

Gradually, more attention has been paid to tricuspid regurgitation. Formerly the ???forgotten valvular heart disease,??? it has been recognized as hav......

LncRNA-ZFAS1 Promotes Myocardial Ischemia-Reperfusion Injury Through DNA Methylation-Mediated Notch1 Down-Regulation in Mice

期刊: JACC-BASIC TO TRANSLATIONAL SCIENCE, 2022; 7 (9)

The most devastating and catastrophic deterioration of myocardial ischemia-reperfusion injury (MIRI) is car-diomyocyte death. Here we aimed to evaluat......

Circulating Hepatocyte Growth Factor Reflects Activation of Vascular Repair in Response to Stress

期刊: JACC-BASIC TO TRANSLATIONAL SCIENCE, 2022; 7 (8)

Hepatocyte growth factor (HGF) is released by stressed human vascular cells and promotes vascular cell repair responses in both autocrine and paracrin......

Propionate Alleviates Abdominal Aortic Aneurysm by Modulating Colonic Regulatory T-Cell Expansion and Recirculation br

期刊: JACC-BASIC TO TRANSLATIONAL SCIENCE, 2022; 7 (9)

Emerging evidence supports that intestinal microbial metabolite short-chain fatty acids (SCFAs) increase the pool of regulatory T cells (Tregs) in the......

Validation of a Novel Renal Denervation System With Cryoablation A Preclinical Study and Case Series

期刊: JACC-BASIC TO TRANSLATIONAL SCIENCE, 2022; 7 (2)

Recently, we designed a renal denervation with cryoablation (Cryo-RDN) system using liquid nitrogen and proved its short-term safety and effectiveness......

Parkin Insufficiency Accentuates High-Fat Diet-Induced Cardiac Remodeling and Contractile Dysfunction Through VDAC1-Mediated Mitochondrial Ca2+ Overload

期刊: JACC-BASIC TO TRANSLATIONAL SCIENCE, 2022; 7 (8)

Mitochondrial Ca2+ overload contributes to obesity cardiomyopathy, yet mechanisms that directly regulate it remain elusive. The authors investigated t......

Dynamic Multiscale Regulation of Perfusion Recovery in Experimental Peripheral Arterial Disease A Mechanistic Computational Model

期刊: JACC-BASIC TO TRANSLATIONAL SCIENCE, 2022; 7 (1)

In peripheral arterial disease (PAD), the degree of endogenous capacity to modulate revascularization of limb muscle is central to the management of l......

Targeting Myocardial Mitochondria- STING-Polyamine Axis Prevents Cardiac Hypertrophy in Chronic Kidney Disease

期刊: JACC-BASIC TO TRANSLATIONAL SCIENCE, 2022; 7 (8)

Chronic kidney disease (CKD) is well recognized as a distinct contributor to cardiac hypertrophy, while the un-derlying mechanism remains incompletely......

A Novel Puncturable Atrial Septal Defect Occluder

期刊: JACC-BASIC TO TRANSLATIONAL SCIENCE, 2022; 7 (12)

ReAces is a novel puncturable transcatheter atrial septal defect occluder. The device success rate was 100% (n = 14 of 14) in the animal experiment. F......

PTP1B Inhibition Improves Mitochondria Dynamics to Alleviate Calcific Aortic Valve Disease Via Regulating OPA1 Homeostasis

期刊: JACC-BASIC TO TRANSLATIONAL SCIENCE, 2022; 7 (7)

There are currently no pharmacological therapies for calcific aortic valve disease (CAVD). Here, we evaluated the role of protein tyrosine phosphatase......

Nicotinamide Mononucleotide Alleviates Cardiomyopathy Phenotypes Caused by Short-Chain Enoyl-Coa Hydratase 1 Deficiency

期刊: JACC-BASIC TO TRANSLATIONAL SCIENCE, 2022; 7 (4)

Short-chain enoyl-CoA hydratase 1 (ECHS1) deficiency plays a rote in cardiomyopathy. Whether ECHS1 deficiency causes or is only associated with cardio......

A Novel LncRNA SNHG3 Promotes Osteoblast Differentiation Through BMP2 Upregulation in Aortic Valve Calcification

期刊: JACC-BASIC TO TRANSLATIONAL SCIENCE, 2022; 7 (9)

Based on high-throughput transcriptomic sequencing, SNHG3 was among the most highly expressed long non -coding RNAs in calcific aortic valve disease. ......

SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis

期刊: JACC-BASIC TO TRANSLATIONAL SCIENCE, 2021; 6 (4)

There is ongoing debate as to whether cardiac complications of coronavirus disease-2019 (COVID-19) result from myocardial viral infection or are secon......

Interleukin-1 beta, Oxidative Stress, and Abnormal Calcium Handling Mediate Diabetic Arrhythmic Risk

期刊: JACC-BASIC TO TRANSLATIONAL SCIENCE, 2021; 6 (1)

Diabetes mellitus (DM) is associated with increased arrhythmia. Type 2 DM (T2DM) mice showed prolonged QT interval and increased ventricular arrhythmi......

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