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Evolution and genomic insight into methicillin-resistant Staphylococcus aureus ST9 in China

期刊: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2021; 76 (7)

Objectives: To reconstruct the evolutionary history and genomic epidemiology of Staphylococcus aureus ST9 in China. Methods: Using WGS analysis, we de......

Evaluation of the antimicrobial activity of ridinilazole and six comparators against Chinese, Japanese and South Korean strains of Clostridioides difficile

期刊: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2021; 76 (4)

Background: Clostridioides difficile is the most common cause of antimicrobial-associated diarrhoea in high-income countries. Fluoroquinolone resistan......

Allele-based analysis revealed the critical functions of region 277-297 in the NorA efflux pump of Staphylococcus aureus

期刊: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2021; 76 (6)

Objectives: The NorA efflux pump in Staphylococcus aureus mediates resistance to many fluoroquinolone (FQ) antibiotics. Three norA alleles with high s......

Emergence of a Salmonella enterica serovar Typhimurium ST34 isolate, CFSA629, carrying a novel mcr-1.19 variant cultured from egg in China

期刊: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2021; 76 (7)

Objectives: This study aimed to characterize the genomic features of a Salmonella enterica serovar Typhimurium ST34 isolate, CFSA629, which carried a ......

In vitro and in vivo synergistic effects of tigecycline combined with aminoglycosides on carbapenem-resistant Klebsiella pneumoniae

期刊: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2021; 76 (8)

Objectives: Carbapenem-resistant Klebsiella pneumoniae (CR-KP) infections represent severe threats to public health worldwide. The aim of this study w......

High percentage of the ceftriaxone-resistant Neisseria gonorrhoeae FC428 clone among isolates from a single hospital in Hangzhou, China

期刊: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2021; 76 (4)

Objectives: Ceftriaxone is currently the last-remaining empirical antimicrobial therapy for treatment of gonorrhoea. However, the high-level ceftriaxo......

Transferable Acinetobacter baumannii plasmid pDETAB2 encodes OXA-58 and NDM-1 and represents a new class of antibiotic resistance plasmids

期刊: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2021; 76 (5)

Objectives: To characterize a bla(OXA-58)- and bla(NDM-1)-containing MDR plasmid from a rare Acinetobacter baumannii lineage and compare it with relat......

VraCP regulates cell wall metabolism and antibiotic resistance in vancomycin-intermediate Staphylococcus aureus strain Mu50

期刊: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2021; 76 (7)

Objectives: Vancomycin-intermediate Staphylococcus aureus (VISA) is increasingly being reported. Previous studies have shown that vraC and vraP may be......

Whole-genome sequencing of strains of Vibrio spp. from China reveals different genetic contexts of bla(CTX-M-14) among diverse lineages

期刊: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2021; 76 (4)

Objectives: To investigate the prevalence and genetic contexts of the bla(CTM-M-14) gene harboured by foodbome isolates of Vibrio spp. in China. Metho......

Optimal initial antibiotic regimen for the treatment of acute appendicitis: a systematic review and network meta-analysis with surgical intervention as the common comparator

期刊: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2021; 76 (7)

Background: The optimal antibiotic regimen for the medical management of acute appendicitis remains unknown due to a lack of head-to-head comparisons ......

Emergence of a multidrug resistance efflux pump with carbapenem resistance gene bla(VIM-2) in a Pseudomonas putida megaplasmid of migratory bird origin

期刊: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2021; 76 (6)

Background: Tigecycline and carbapenems are regarded as vital antimicrobials to treat serious bacterial infections. Co-occurrence of resistance genes ......

Pharmacokinetic/pharmacodynamic evaluation of tobramycin dosing in critically ill patients: the Hartford nomogram does not fit

期刊: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2021; 76 (9)

Objectives: Extended-interval dosing of tobramycin is widely applied in patients with the Hartford nomogram as a representative, while this dosing app......

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