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Gentiopicroside ameliorates ovalbumin-induced airway inflammation in a mouse model of allergic asthma via regulating SIRT1/NF-kappa B signaling pathway

期刊: PULMONARY PHARMACOLOGY & THERAPEUTICS, 2021; 68 ()

Allergic asthma is a common airway inflammatory disorder with increasing morbidity and mortality worldwide. Gentiopicroside (GPS) is a secoiridoid gly......

Chrysin prevents lipopolysaccharide-induced acute lung injury in mice by suppressing the IRE1 alpha/TXNIP/NLRP3 pathway

期刊: PULMONARY PHARMACOLOGY & THERAPEUTICS, 2021; 68 ()

Acute lung injury (ALI) remains a serious challenge in the intensive care unit. Inflammation plays a key role in the progression of ALI. Chrysin (CHR)......

CXCR1 correlates to poor outcomes of EGFR-TKI against advanced non-small cell lung cancer by activating chemokine and JAK/ STAT pathway

期刊: PULMONARY PHARMACOLOGY & THERAPEUTICS, 2021; 67 ()

Objective: CXCR1, a member of the seven-transmembrane chemokine receptor family, promotes cell proliferation and metastasis in many tumors. The presen......

Pharmacokinetics and safety of tiotropium plus olodaterol 5 mu g/5 mu g fixed-dose combination in Chinese patients with COPD

期刊: PULMONARY PHARMACOLOGY & THERAPEUTICS, 2020; 63 ()

Background: Chronic obstructive pulmonary disease (COPD) is one of the major causes of morbidity and mortality worldwide and in China. For patients wi......

The proliferative and anti-apoptosis functions of KGF/KGFR contributes to bronchial epithelial repair in asthma

期刊: PULMONARY PHARMACOLOGY & THERAPEUTICS, 2020; 63 ()

This study aimed to investigate the effect of keratinocyte growth factor (KGF) on the apoptosis, proliferation, damage repair, intercellular adhesion,......

Current and emerging treatment options for lung cancer in patients with pre-existing connective tissue disease

期刊: PULMONARY PHARMACOLOGY & THERAPEUTICS, 2020; 63 ()

An association between connective tissue disease (CTD) and lung cancer has been claimed in accumulating studies. However, the management of lung cance......

Magnesium lithospermate B improves pulmonary artery banding induced right ventricular dysfunction by alleviating inflammation via p38MAPK pathway

期刊: PULMONARY PHARMACOLOGY & THERAPEUTICS, 2020; 63 ()

Backgroud: Magnesium lithospermate B (MLB) is a major bioactive component of Slavia miltiorrhiza, which has been widely used in heart diseases on acco......

Comparative anti-inflammatory effect of curcumin at air-liquid interface and submerged conditions using lipopolysaccharide stimulated human lung epithelial A549 cells

期刊: PULMONARY PHARMACOLOGY & THERAPEUTICS, 2020; 63 ()

Background: Inhalation of aerosolized drugs is a promising entry route for rapid and non-invasive therapeutics delivery to the lung. Curcumin exhibits......

Tetrahydropalmatine protects against acute lung injury induced by limb ischemia/reperfusion through restoring PI3K/AKT/mTOR-mediated autophagy in rats

期刊: PULMONARY PHARMACOLOGY & THERAPEUTICS, 2020; 64 ()

Background: Limb ischemia/reperfusion (I/R) is a common clinical process that frequently induces acute lung injury (ALI). Tetrahydropalmatine (THP) is......

Role of 20-hydroxyeicosatetraenoic acid in pulmonary hypertension and proliferation of pulmonary arterial smooth muscle cells

期刊: PULMONARY PHARMACOLOGY & THERAPEUTICS, 2020; 64 ()

Objective: To investigate the level of 20-Hydroxyeicosatetraenoic acid (20-HETE) in model of pulmonary hypertension (PH) and its effect on the prolife......

Dihydroquercetin attenuates lipopolysaccharide-induced acute lung injury through modulating FOXO3-mediated NF-kappa B signaling via miR-132-3p

期刊: PULMONARY PHARMACOLOGY & THERAPEUTICS, 2020; 64 ()

Background: Dihydroquercetin (DHQ) is a potent flavonoid which has been demonstrated to have multiple biological activities including anti-inflammatio......

ORMDL3 modulates airway epithelial cell repair in children with asthma under glucocorticoid treatment via regulating IL-33

期刊: PULMONARY PHARMACOLOGY & THERAPEUTICS, 2020; 64 ()

Background: Study found that glucocorticoids, as first-line treatments for asthma, fails to prevent asthma recurrence. Orosomucoid-like (ORMDL) 3 is a......

LncRNA STARD13-AS blocks lung squamous carcinoma cells growth and movement by targeting miR-1248/C3A

期刊: PULMONARY PHARMACOLOGY & THERAPEUTICS, 2020; 64 ()

Background: This research aims to illustrate the effect of lncRNA StAR Related Lipid Transfer Domain Containing 13 antisense RN (STARD13-AS)/miR-1248/......

Genetic variants in MIR2113 and MIR129-LEP are associated with the susceptibility of COPD in the Chinese Han population

期刊: PULMONARY PHARMACOLOGY & THERAPEUTICS, 2020; 64 ()

Background: Chronic obstructive pulmonary disease (COPD) is the result of interaction between genetic and environmental factors. In this study, we aim......

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