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Dynamic changes in Beclin-1, LC3B and p62 at various time points in mice with temporary middle cerebral artery occlusion and reperfusion (tMCAO)

期刊: BRAIN RESEARCH BULLETIN, 2021; 173 ()

Ischaemic stroke is attributable to cerebrovascular disease and is associated with high morbidity, disability, mortality and recurrence. Autophagy is ......

Expression, methylation and prognostic feature of EMILIN2 in Low-Grade-Glioma

期刊: BRAIN RESEARCH BULLETIN, 2021; 175 ()

Low-grade gliomas (LGGs) are slow-growing brain cancer in central nervous system neoplasms. EMILIN2 is an extracellular matrix (ECM) protein which cou......

Neuroprotective effects of low-intensity transcranial ultrasound stimulation combined with Baicalin intervention on traumatic brain injury in animals

期刊: BRAIN RESEARCH BULLETIN, 2021; 175 ()

Low-intensity transcranial ultrasound stimulation (LITUS) can improve the inflammatory reaction after traumatic brain injury (TBI), and Baicalin also ......

Experimental models and examination methods of retinal detachment

期刊: BRAIN RESEARCH BULLETIN, 2021; 169 ()

Retinal detachment refers to the separation of the retinal neuroepithelium and pigment epithelium, usually involving the death of photoreceptor cells.......

Neonatal LPS exposure reduces ATP8A2 level in the prefrontal cortex in mice via increasing IFN-gamma level

期刊: BRAIN RESEARCH BULLETIN, 2021; 171 ()

Neonatal lipopolysaccharide (LPS) exposure can cause depressive-like behaviors in rodents involving elevated interferon (IFN)-gamma. Studies have link......

Immunization with A beta 3-10-KLH vaccine improves cognitive function and ameliorates mitochondrial dysfunction and reduces Alzheimer's disease-like pathology in Tg-APPswe/PSEN1dE9 mice

期刊: BRAIN RESEARCH BULLETIN, 2021; 174 ()

Alzheimer's disease is a common cause of dementia, for which no disease-modifying therapy is yet available. A beta 3-10-KLH, a vaccine for active immu......

The p38 MAPK/NF-kappa B pathway mediates GLT-1 up-regulation during cerebral ischemic preconditioning-induced brain ischemic tolerance in rats

期刊: BRAIN RESEARCH BULLETIN, 2021; 175 ()

Our previous finding suggests that p38 MAPK contributes to the GLT-1 upregulation during induction of brain ischemic tolerance by cerebral ischemic pr......

CDDO-Im exerts antidepressant-like effects via the Nrf2/ARE pathway in a rat model of post-stroke depression

期刊: BRAIN RESEARCH BULLETIN, 2021; 173 ()

Increasing evidence suggests that oxidative damage and neuroinflammation play a critical role in the pathogenesis of post-stroke depression (PSD). The......

Anti-CD47 antibody administration via cisterna magna in proper dosage can reduce perihematomal cell death following intracerebral hemorrhage in rats

期刊: BRAIN RESEARCH BULLETIN, 2021; 174 ()

Objective: The secondary injury caused by RBC autolysis after intracerebral hemorrhage (ICH) can be reduced by increasing the efficiency of microglia ......

microRNA-139-5p alleviates neurological deficit in hypoxic-ischemic brain damage via HDAC4 depletion and BCL-2 activation

期刊: BRAIN RESEARCH BULLETIN, 2021; 169 ()

Aim: Studies paid much attention to the role of microRNAs (miRNAs) in hypoxic-ischemic brain damage (HIBD) but not much to miR-139-5p. Thus, this stud......

Tracking whole-brain connectivity dynamics in the resting-state fMRI with post-facial paralysis synkinesis

期刊: BRAIN RESEARCH BULLETIN, 2021; 173 ()

Background: Resting-state functional magnetic resonance imaging (rs-fMRI) is widely applied to explore abnormal functional connectivity (FC) in patien......

Therapeutic potential of catalpol and geniposide in Alzheimer's and Parkinson's diseases: A snapshot of their underlying mechanisms

期刊: BRAIN RESEARCH BULLETIN, 2021; 174 ()

Rehmannia glutinosa, the fresh or dried root of Rehmannia glutinosa (Gaertn.) Libosch. ex Fisch. & Mey., and Gardenia, the fruit of Gardenia jasmi......

Treadmill exercise alleviates neuronal damage by suppressing NLRP3 inflammasome and microglial activation in the MPTP mouse model of Parkinson's disease

期刊: BRAIN RESEARCH BULLETIN, 2021; 174 ()

Treadmill exercise has been recognized as an effectively therapeutic strategy for Parkinson's disease (PD). However, its exact molecular mechanism of ......

Different combinations of high-frequency rTMS and cognitive training improve the cognitive function of cerebral ischemic rats

期刊: BRAIN RESEARCH BULLETIN, 2021; 175 ()

Poststroke cognitive impairment (PSCI) occurs frequently after stroke, but lacks effective treatments. Previous studies have revealed that high-freque......

MicroRNA-16-5p/BTG2 axis affects neurological function, autophagy and apoptosis of hippocampal neurons in Alzheimer's disease

期刊: BRAIN RESEARCH BULLETIN, 2021; 175 ()

Objective: Studies have focused on the functions of microRNAs (miRNAs) in Alzheimer's disease (AD), but not much on miR-16-5p. Hence, this study inten......

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